H. Zheng

This study compares the DNBSEQ-G400 and Illumina MiSeq platforms for metabarcoding fungal communities, finding DNBSEQ-G400 to be more accurate, less biased, and cost-effective.

This study investigates the PK/PD relationship of tilmicosin against M. hyopneumoniae, identifies resistance mechanisms, and suggests optimal dosing regimens.

This study identifies therapy-induced transdifferentiation as a mechanism of EGFR-targeted therapy resistance in gliomas, independent of EGFR signaling, and suggests combinatorial therapies targeting both EGFR and transdifferentiation pathways.

This study analyzes gut microbiome data from 361 elderly women to explore its association with bone mass loss and bone mineral density.

The paper shows that oxidative stress in NSPCs activates the IFN-I response via FOXO3-regulated lamin modifications, preserving their regenerative potential.

This study compares SARS-CoV-2 infection outcomes in three non-human primate species, finding that M. mulatta is most susceptible, followed by M. fascicularis and C. jacchus.

This study shows that exosomes from SVV-infected cells can carry and transmit SVV between susceptible and non-susceptible cells, and this transmission is resistant to neutralizing antibodies.

This study shows that satellite plasmids can help maintain newly acquired accessory genes in bacteria by reducing their fitness burden.

This study identifies CIC as a critical regulator of neuronal differentiation by repressing VGF expression through a corepressor complex, linking its dysfunction to brain tumor development.

This study challenges two established dogmas about bacterial cell growth and reveals a new linear relation between cell mass and division count across a wide range of growth rates in E. coli.

This study identifies YAP1 as a context-specific driver for the squamous subtype of pancreatic ductal adenocarcinoma and shows WNT5A promotes tumor progression through YAP1 activation.

This study shows that the Gly129 residue in FMDV-VP3 enhances viral pathogenicity by promoting apoptosis and autophagy through p53 interaction, and this residue is conserved across picornaviruses.

This study identifies SKI-73 as a CARM1 chemical probe that reduces breast cancer cell invasion by altering epigenetic plasticity, distinct from CARM1 knockout effects.

The paper presents the first in situ structure of the Legionella T2SS using cryo-ET, revealing architectural similarities and differences with T4P and supporting the piston model for substrate extrusion.

This study reports crystal structures of the HMCES SRAP domain bound to DNA-damage substrates, revealing how HMCES recognizes and binds different DNA structures for crosslinking.

This study identifies two inhibitors of the Mtb DosRST regulatory system, showing they target different components of the pathway and reduce hypoxia-induced persistence.

This study identifies CHGB as a novel anion channel essential for secretory granule maturation in endocrine cells, showing its role in granule acidification and function in both intracellular and extracellular contexts.

This study develops a multi-hierarchical nano-SAR assessment for Fe2O3 nanomaterials, revealing how their properties influence bio-effects like cell migration and inflammation.

This study shows that ER+ breast cancer cells have the RET signaling pathway components but lack RET ligands needed for endocrine resistance, linking RET ligand expression to therapy response and survival.

The paper evaluates inhibitors of mutant IDH1 and IDH2 using biochemical and cell-based assays to identify effective compounds for cancer therapy.

This study identifies AC2P36 as a compound that depletes Mtb thiol pools at acidic pH, enhancing sensitivity to antibiotics and oxidizing agents.