J. Gao

This study identifies SCARECROW's role in maintaining telomere integrity and genome stability in Arabidopsis root stem cells through regulation of TEN1 and related factors.

This paper isolates and characterizes five sterols from Laminaria japonica and evaluates their anti-inflammatory and antioxidant activities through enzyme inhibition and molecular docking.

This paper shows metformin reduces anxiety and depression-like symptoms in mice during methamphetamine withdrawal by modulating gut microbiota-derived inosine.

This study shows that m6A modifications regulate intestinal immunity and rotavirus infection by modulating IRF7 and IFN expression through METTL3 in intestinal epithelial cells.

This study uses iTRAQ-based proteomics to identify cold stress-responsive proteins in japonica rice seedlings, finding 289 regulated proteins involved in photosynthesis and metabolism.

This study identifies STK11IP as a lysosome-specific mTORC1 substrate that regulates lysosomal acidification and autophagy, with implications for therapeutic targeting of autophagy-related diseases.

The paper identifies miR-106b-5p in exosomes from Mtb-infected macrophages that promote Mtb survival by regulating lipid metabolism and apoptosis in uninfected macrophages.

This study shows that 1,25(OH)2D3 reduces hepatic insulin resistance in diabetic rats by improving antioxidant status and enhancing AKT/GLUT2 expression.

This study identifies non-coding NFKBIZ 3' UTR mutations as drivers of DLBCL growth and resistance to NF-κB-targeted therapies, suggesting their potential as biomarkers.

The paper compares the antigenicity of neuraminidase (NA) from circulating influenza A viruses to vaccine strains, finding antigenic similarity and highlighting C-terminal substitutions affecting H3N2 NA reactivity.

Phylodynamic analyses reveal that variation in rates of early geographic spread of COVID-19 are correlated with intervention measures.

This study evaluates how different designs of recombinant influenza neuraminidase (rNA) affect protective efficacy in mice, showing that domain combinations significantly influence immunogenicity and protection.

This study isolates and characterizes Helcococcus ovis from clinical bovine mastitis in China, showing its antimicrobial sensitivity and pathogenic potential in a murine model.

This study identifies HDAC1-3 and SIRT1-3 as enzymes that remove histone lactylation marks, contrasting with the known role of acetylation.

This study identifies C28 as a compound that modulates IKs channel voltage sensor activation, reversing drug-induced APD prolongation without affecting normal APD.

This study shows that FGF21-PEG normalizes plasma glucose in two mouse diabetes models, even when insulin receptor function is impaired.

The paper shows that exchanging viral backbone genes can increase neuraminidase content in influenza virions, leading to better NA antibody responses in mice.

This study examines how different light spectra affect nitrogen assimilation and content in Quercus variabilis seedlings under nitrogen pulses.

The paper shows that cell wall damage disrupts root hair patterning and floral morphogenesis via attenuation of SUB signaling in Arabidopsis.

This study establishes a mouse model of renal cell carcinoma showing that 9p21 loss drives aggressive tumor evolution with chromosomal instability and metastasis.

This study identifies Il13 enhancers that mediate gene transcription in response to antigenic stimulation by analyzing histone modifications and transcription factor binding sites.

This study evaluates the impact of preoperative α-blocker use on outcomes in extra-adrenal retroperitoneal paraganglioma surgeries, finding no significant differences in postoperative complications.

This study uses deep learning to segment late blight lesions in potato field images and quantify disease severity, achieving high background segmentation accuracy and moderate lesion detection.

This paper investigates how Esteya vermicola colonizes pine trees and interacts with Bursaphelenchus xylophilus, revealing specific infection mechanisms and colonization patterns in healthy and infected trees.

This study investigates whether chloroquine and hydroxychloroquine inhibit 2019-nCoV infection by blocking ACE2 binding, showing both drugs suppress virus entry into ACE2-expressing cells.

This study investigates the roles of pUL16, pUL21, and pUs3 in HSV-2 nuclear egress, revealing distinct functions for pUL16 and a novel role for pUL21 in regulating NEC activity.

This study investigates glycyrrhizin's effect on LPS-induced inflammation in goat ruminal epithelial cells, finding it reduces inflammatory cytokines and protects cell structure.

This paper develops a CRISPR-based DNA detection method (CADD) that rapidly and specifically detects DNA from bacteria, cancer cells, and viruses in 30 minutes at room temperature.

The paper identifies low-molecular-weight drugs that inhibit SARS-CoV-2 main protease using a fragment-based approach, finding niacin and hit 1 bind to the catalytic pocket and leading to the discovery of four drug candidates.