J. Hu

This paper introduces a high-throughput drug screening method called CEBIT that detects biomolecular interactions and enzyme inhibitors by using phase-separated compartments.

The paper reports the complete genome sequence of a novel BPV type 15 strain from a cow in southern Xinjiang and places it phylogenetically within the Xipapillomavirus genus.

This study investigates how substrate structure influences stereoselectivity in MCO-catalyzed oxidative coupling reactions mediated by VdtB and VdtD in the biosynthesis of viriditoxin.

This study identifies the key interaction region and phosphorylation site of EcaICE1 that mediates its interaction with EcaHOS1 in Eucalyptus.

This study identifies the transcription activation domain and interaction region of EcaICE1 with EcaSIZ1 in Eucalyptus camaldulensis, revealing potential SUMOylation pathway similarities to Arabidopsis thaliana.

This study identifies miR476a/RFL as a regulator of adventitious root formation in poplar through mitochondrial homeostasis and auxin pathway modulation.

This study constructs large-scale, morphologically controlled λ-DNA networks using a DC electric field and investigates factors affecting their structure.

The paper develops DPY30-targeting peptides that inhibit blood cancer cell growth by disrupting ASH2L binding and H3K4 methylation.

The paper identifies GATA2 overexpression in early-stage atherosclerotic macrophages as a driver of functional defects linked to atheroma formation.

The paper uses super-resolution imaging to show that chromatin structure decompacts and fragments during early cancer development, even before tumors form, and this change may improve cancer detection and risk assessment.

This study introduces a method to genotype MHC class I and II from rhesus macaque exome sequences with high accuracy, outperforming conventional methods.

The paper identifies a gene cluster responsible for viriditoxin biosynthesis in fungi, elucidates its pathway, and identifies key enzymes involved.

This paper shows that papillomavirus can be transmitted through blood and cause infections in animal models, suggesting blood transfusion as a potential route for HPV infection and cancer in humans.

This study identifies α-tubulin in Laodelphax striatellus as a facilitator of rice stripe virus (RSV) passage through midgut and salivary glands, enhancing horizontal transmission.

This study shows that spotted doves can be infected with SFTSV, with severity depending on viral strain and dose, and suggests they may play a role in virus transmission.

This study shows that vimentin intermediate filaments provide cytoplasmic mechanics that enhance strength, stretchability, resilience, and toughness under severe deformations.

The paper identifies MoRgs7 as a GPCR-like receptor in Magnaporthe oryzae that senses hydrophobic surfaces via hydrophobic interactions, couples with Gα subunit MoMagA for endocytosis, and promotes cAMP signaling required for appressorium formation and pathogenicity.

The paper introduces Split-miniSOG, a PCA method to detect and localize PPIs using correlated light and electron microscopy.

This study demonstrates that genome-skimming accurately quantifies mixed pollen samples, showing high repeatability and correlation between sequence reads and pollen proportions.

This study examines how food type and Nosema ceranae infection affect the gut microbiota of Apis cerana workers, finding that beebread supports a more stable microbiota and reduces mortality from infection.

This study identifies dimer-dependent catalytic activity in RAF family kinases through analysis of oncogenic mutants, revealing differential inhibitor resistance and MEK phosphorylation mechanisms.

The paper introduces Craniobot, an automated cranial microsurgery platform for mice, enabling precise skull modifications using CNC milling and open-source software.

This paper develops a method to enable genetically labeled cryofixed samples to be analyzed with SBEM and 3D CLEM, overcoming previous technical limitations.

This study identifies AMPKi as a compound that blocks 14-3-3 binding to CRAF, overcoming RAF inhibitor resistance by preventing paradoxical CRAF activation in cancer cells.

This study identifies USP11 as a deubiquitylase that stabilizes p21, affecting cell cycle progression and DNA damage responses.

This study examines how environmental and genetic factors influence lifetime fitness in Arabidopsis thaliana across different planting seasons and locations.