J. Hu

This study identifies active components and anticancer targets of rhubarb using network pharmacology, revealing key compounds and pathways involved in cancer regulation.

This study evaluates the neutralization sensitivity of SARS-CoV-2 variants N501Y.V1 and N501Y.V2 to convalescent sera and monoclonal antibodies, finding reduced neutralization activity.

This study shows that silencing lncRNA NEAT1 suppresses ESCC cell proliferation, migration, and invasion by regulating the miR-1299/MMP2 axis.

The study identifies a 416-bp deletion in the AFF gene's promoter that reduces its expression, leading to all-flesh tomato fruits and providing insights into berry fruit evolution.

The paper identifies O-GlcNAcylation sites on COPII components and shows their potential role in nutrient-sensitive pathway regulation.

This study identifies bis-benzylisoquinoline alkaloids as SARS-CoV-2 entry inhibitors through in vitro screening of natural products.

This paper introduces DEAS, a simulator that predicts crop latitude adaptation using florigen gene expression, enabling faster breeding for climate-resilient crops.

This study investigates DNA methylation heritability and genetic architecture in threespine stickleback ecotypes, finding genetic variance explains 24-35% of methylation variance and detecting both cis- and trans-meQTLs.

This paper identifies and characterizes a potent human monoclonal antibody, HB27, that blocks SARS-CoV-2 receptor binding and membrane fusion, showing protective effects in mice and non-adverse effects in rhesus macaques.

This study shows the bone microenvironment enhances metastatic potential of cancer cells, enabling further dissemination and multi-organ metastasis, independent of genetic selection.

This study identifies RaACE2 as a functional receptor for SARS-CoV-2 and RaTG13, and evaluates ACE2s from 16 species for their ability to mediate virus entry.

The paper presents an improved strategy for deep N-glycomics with optimized sample prep, isotope-based QC, new libraries, and algorithms, but the manuscript was withdrawn due to incomplete data.

This study profiles protein crotonylation in different mouse pluripotent states, identifying 3628 sites and showing that crotonyl-CoA promotes proteasome activity and delays differentiation.

This study shows that dyclonine inhibits TRPV3 channels in keratinocytes, rescuing cell death and reducing pruritus in a mouse model.

This study identifies a linear epitope on SARS-CoV-2 S-RBD recognized by a potent neutralizing antibody and shows its potential for vaccine design.

This paper introduces a rapid screening system to identify potent neutralizing antibodies against SARS-CoV-2 and demonstrates its effectiveness in discovering high-potency antibodies.

This study identifies structural defects in ZIP4's extracellular domain caused by AE mutations, leading to mistrafficking and loss of zinc uptake.

This study develops a virus-free live-cell visualization system for SARS-CoV-2 entry using a fluorescent spike trimer probe, enabling analysis of neutralizing antibodies and inhibitors.

This study investigates how Parkinson's Disease mutations affect LRRK2 activation and subcellular localization through conformational changes and domain interactions.

This study shows the D614G mutation in SARS-CoV-2 spike protein increases viral infectivity and is more susceptible to elastase cleavage, with minimal impact on neutralizing antibody efficacy.

This study shows that AKAP95 protein condensates regulate splicing and tumorigenesis through their biophysical properties.

This study shows that Bcl6 deletion in Treg cells reduces tumor growth by impairing their suppressive function, and increased Bcl6 expression is linked to poor cancer outcomes.

This study compares the immune landscape of a genetically-engineered murine glioma model to human glioma using single-cell sequencing, finding similar immunosuppressive features but differences in immune cell composition between mouse models and human samples.

This study shows that cancer cells with increased MRTF signaling are more rigid and vulnerable to immune cells, revealing a mechanical aspect of immunosurveillance.

The paper identifies an immunosuppression signature (IMS) and shows that its ratio to an IFN-γ signature better predicts anti-PD-1 therapy response in melanoma than existing biomarkers.

The paper shows that inhibiting the integrin-TGF-β axis enhances NK cell function against glioblastoma stem cells, suggesting it as a therapeutic target.

This study shows rottlerin reduces DSS-induced colitis in mice by enhancing intestinal barrier function through the Epac-2/Rap-1 signaling pathway.

This study shows that HBV infection enhances the hexosamine biosynthesis pathway, leading to O-GlcNAcylation of SAMHD1, which boosts antiviral immunity against HBV and HIV-1.

This study identifies an essential aspartate residue for lanthanide coordination and function in XoxF and ExaF dehydrogenases.

This paper develops and evaluates two novel PET tracers, [18F]fluorophenylglutamine and [18F]fluorobiphenylglutamine, for imaging glutamine metabolism in tumors, showing promising in vitro and in vivo results.