J. Li

The paper analyzes donor pancreata to define the transcriptomic signature and microenvironment of early pre-neoplastic lesions, finding PanIN lesions are common in healthy individuals and show transcriptional similarity to cancer cells.

This study identifies RELMα's role in sex-specific obesity protection by regulating adipose macrophages and eosinophils, revealing a therapeutic target for obesity.

This study uses phylogenomic analysis of macaque genomes to show that incomplete lineage sorting and ancient hybridization contributed to the radiation of macaques.

This paper introduces a high-throughput single-molecule tracking platform to study protein dynamics and drug interactions, identifying novel mechanisms and therapeutics.

This study shows adult hepatocytes and biliary epithelial cells can proliferate extensively in vitro and differentiate into hepatocyte-like cells, supporting their use in liver regenerative medicine.

The paper catalogs and profiles the gut virome in Chinese populations, identifying novel viruses and disease-associated viral signatures.

This study investigates the deacetylase-dependent and independent roles of HDAC3 in cardiomyopathy using Drosophila, finding it maintains cardiac contractility and prevents Pericardin deposition independently of its deacetylase activity, but regulates triglyceride homeostasis through this activity.

The paper identifies paired NLRs in Solanaceae species and shows their coordinated role in modulating NRC3-mediated ETI to enhance age-dependent immunity.

This study identifies cGAS-STING signaling as a driver of late cardiac toxicity after DNA-damaging cancer therapies and shows that targeting this pathway can mitigate cardiotoxicity.

This study identifies chr8 gains and 4E-BP1 expression as prognostic markers in Ewing sarcoma, showing they drive cancer progression by promoting proliferation and sensitizing to CDK4/6 inhibitors.

The paper introduces SMRT-AgRenSeq-d, a method for identifying NLR resistance genes in potato, and applies it to find nine strong candidates for the nematode resistance gene Gpa5.

The paper generates and indexes an EMS mutant library for KN9204 wheat to enhance functional genomics and genetic manipulation for agronomic traits.

The paper establishes a reference library of TCR-beta germline genes in three bat species and analyzes the TCR-beta repertoire diversity in an additional bat species.

This study uses super-resolution microscopy to analyze platelet morphology, ultrastructure, and function in acute ischemic stroke patients, revealing structural and functional changes and demonstrating the utility of the technique for assessing antiplatelet drugs.

This study identifies a mutual regulatory loop between PFKP and VEGF that promotes glioblastoma growth through AKT-mediated signaling and glycolytic enhancement.

The study analyzes viral diversity in individual bats to assess co-infection, spillover, and zoonotic risk of potential viruses.

This study shows O-GlcNAcylation of YTHDF1 enhances its cytosolic localization and promotes colorectal cancer by increasing c-Myc expression.

The paper analyzes metagenomic and metatranscriptomic data from cold seeps to identify As-cycling genes and microbes, revealing unexpected diversity and functional roles in arsenic transformation.

This study simulates adaptation in recombining populations on tunable fitness landscapes, finding that recombination hinders movement through rugged landscapes and that epistasis and recombination interact to influence allele fixation.

This paper identifies and engineers a high-fidelity Cas12i variant with broad PAM recognition and minimal off-target activity for improved genome editing.

The paper investigates phage resistance mechanisms in Klebsiella pneumoniae and shows how these can both increase and decrease antibiotic susceptibility.

The paper identifies novel unconventional targeting signals in PDLP5 and related proteins that mediate plasmodesmal localization and function.

This study examines the prevalence and risk factors of HIV-1 associated thrombocytopenia and its link to neuroinflammation in a hospital in western China.

The paper provides a comprehensive analysis of immune contexture in IDH stratified human gliomas using single-cell RNA sequencing and spectral cytometry, identifying TREM2 as a novel immunotherapy target.

The paper identifies RNA phase separation as a novel pathway for extracellular miRNA uptake and shows that these miRNAs are delivered to mitochondria via PNPT1.

This study isolates melanoma cells based on melanin content, finding that low-pigment cells are more abundant and have higher tumorigenic potential than high-pigment cells.

This study identifies two groups of metabolites in lamprey buccal glands that modulate host responses and establishes a spatial metabolomics database for lamprey research.

The paper identifies SLK splicing dysregulation in cancers, showing SLK-L promotes metastasis while SLK-S inhibits it, with Rbfox2 regulating this splicing event.