J. Li

This study uses patient-derived iPSCs to identify retinoids as potential therapeutics for Wilson's disease by rescuing ceruloplasmin secretion and reducing oxidative stress.

The paper identifies 84 clinically relevant neoepitope-HLA pairs from 37 shared cancer neoantigens using a combination of biochemical assays and computational methods.

The paper identifies a circulatory pathway for interstitial fluid flow along vasculature adventitia in rats, regulated by heartbeat and respiration.

This study shows that Gaq-PKD/PKCμ regulates IκB transcription to limit NF-κB-mediated inflammation, essential for successful early pregnancy.

This paper develops and tests a CD46-targeted alpha radioimmunotherapy, 212Pb-TCMC-YS5, showing potent tumor growth inhibition and survival improvement in multiple prostate cancer models.

This study links SARS-CoV-2 spike-induced syncytia to cellular senescence and exacerbated heart failure, showing that senolytic drugs and WNK1 inhibitors can mitigate cardiac damage.

OpenLabCluster improves behavioral classification in animal videos using active learning with minimal human annotations, outperforming existing methods across multiple species.

The paper identifies molecular elements and signaling pathways involved in the repression of NRT2 transporters and root nitrate uptake in Arabidopsis in response to nitrate.

This study analyzes the genome and multi-omics data of a C4 plant to uncover evolutionary mechanisms behind C4 photosynthesis development.

This study uses 16S rRNA sequencing to compare microbial communities in IGM and LM patients, finding distinct profiles but no specific pathogen.

The paper chemically modifies host-derived tRNA fragments to selectively inhibit Fusobacterium nucleatum with nanomolar efficacy, while sparing other oral bacteria.

This study maps two recessive resistance genes, bs5 and bs6, against bacterial spot in pepper, aiding marker-assisted breeding and resistance mechanism understanding.

This study shows RGA1 improves pollen tube growth under low-light by enhancing sugar and energy metabolism in rice pistils.

This study develops a culture model to expand adult tubular microvessels on stiff substrates using endothelial cells and pericytes from the same tissue, showing improved growth and morphology with a custom medium.

This study investigates how zearalenone promotes colorectal cancer in mice through multi-omics analyses, revealing pathway activation, metabolic changes, and microbiota alterations.

This study shows that senescence in CD8+ T cells reduces VLA-4 expression, impairing their migration and promoting leptomeningeal metastasis in a mouse model of breast cancer.

This study identifies IL-22 as a key immune-to-brain signal that reduces stress-induced anxiety by acting on septal neurons.

This study identifies acetylation of the fungal effector FolSvp1 as critical for its stability and virulence in tomato plants.

The paper maps global land sharing-sparing patterns between humans and wildlife using human-nature indices and classifies lands into four categories based on biodiversity and human pressure.

This study identifies two broadly neutralizing antibodies against SARS-CoV-2 variants and shows their synergistic neutralization effect, supported by cryo-EM structures.

This study compares selection signatures in mungbean domestication and improvement, identifying distinct genomic footprints associated with different genes and selective pressures.

This study shows that DNA damage-induced O-GlcNAcylation of YTHDC1 enhances its m6A binding, promoting homologous recombination and genome stability.

This study shows that treatment history influences the evolution of carbapenem resistance in Klebsiella by shaping the genetic loci involved and their fitness costs.

This study investigates why mesenchymal stromal cell (MSC) therapy for osteoarthritis (OA) has short-term benefits but lacks long-term efficacy using an in vitro co-culture model.

The paper identifies HLY72, a small-molecule derivative of lycorine, as an anti-obesity agent that targets Na+/K+-ATPase α3 in the brain, promoting lipolysis and thermogenesis without affecting food intake.

This study integrates immunopeptidomics and proteomics to show SARS-CoV-2 disrupts antigen presentation and alters HLA protein dynamics in Calu-3 cells.

This study develops molecular markers for KTI mutant alleles in soybean using CRISPR/Cas9 to aid in breeding low TI trait cultivars.

This study identifies PLK1 O-GlcNAcylation as critical for cell division and shows its role in suppressing uterine carcinoma through biochemical and mouse model experiments.

The paper reports the Cryo-EM structure of active GPR75 with a nanobody, revealing its activation mechanism and providing a structural basis for anti-obesity drug discovery.