J. Liu

This study designs bispecific antibodies from non-Omicron neutralizing antibodies that effectively neutralize the Omicron variant and related sarbecoviruses.

This study identifies CD164 as an essential entry factor for LCMV in human cells and tissues, showing its role in viral infection and potential as a therapeutic target.

This paper develops PharaGlow, an imaging and analysis tool to track feeding and locomotion in large populations of unrestrained C. elegans with high-throughput and precision.

This study evaluates ACE2-Fc combined with neutralizing antibodies against SARS-CoV-2 variants, showing enhanced neutralization and resistance to escape mutations.

This study develops an aging clock based on blood transcriptome data to assess aging rates and evaluate rejuvenation treatments like NMN and Metformin.

The paper identifies ASGR1 as a potential receptor for SARS-CoV-2 that facilitates liver cell infection and suggests soluble ASGR1 as a therapeutic target.

The paper analyzes the distribution of virulence factors in Bacillus cereus strains using phylogenetic and protein prediction methods, revealing clustering based on virulence genes and structural features.

The paper introduces a rapid, highly multiplexed protein detection method for brain tissue, enabling simultaneous detection of 31 proteins in 2 hours with high sensitivity and resolution.

The paper uses FRET sensors to study conformational changes in mGlu2 receptors, showing ligands modulate activation through multiple states.

This paper introduces a high-multiplex single-cell proteomics technology called Cyclic MIST to measure 465 proteins, enabling comprehensive immune cell subpopulation classification.

This study presents three amphioxus reference genomes, revealing insights into chordate gene and chromosome evolution, including WGDs, chromatin architecture, and sex chromosome dynamics.

This paper develops a spatial stochastic model to show how supercoiling affects transcription regulation in E. coli by enabling communication between RNA polymerase molecules and coordinating gene expression.

This study optimizes excitation wavelength and emission window for SPNs to improve imaging quality, showing L1057 NPs achieve superior resolution and signal-to-background ratio in the NIR-IIb window.

This study shows that homologous or heterologous boosters of inactivated vaccines increase neutralizing antibodies against SARS-CoV-2 Omicron, reducing escape from neutralization.

This study identifies RFX6 as a key regulator of β cell dysfunction in early type 2 diabetes through multi-omics analysis of human pancreatic tissue.

This study introduces a transparent ultrasound transducer as a cranial window for multimodal imaging of awake mouse brains.

This study identifies GRP78 as a positive regulator of HBV enveloped-particle secretion through direct interaction with preS1, suggesting it as a potential therapeutic target.

This study identifies increased chondroitin sulfate proteoglycan levels in fibrolamellar carcinoma through gene expression, mass spectrometry, and single-cell sequencing.

The paper develops an optogenetic probiotics system to control enteroendocrine hormone secretion in vivo, demonstrating improved glucose control in animal models.

This study identifies two isoforms of TSP-14 in C. elegans, showing they have distinct localization and functions in development.

This paper introduces a transparent ultrasound transducer array that enables real-time multimodal imaging combining ultrasound, photoacoustic, and optical contrasts.

BipotentR identifies immune-metabolic regulators for bipotent anticancer drugs, demonstrating ESRRA inhibition's effects on tumor metabolism and immune mechanisms.

This study investigates how MutS and DNA interact to load the MutL sliding clamp during mismatch repair, revealing distinct mechanisms from replication clamp loaders.

This study identifies epigenetic regulators as tumor suppressors in breast cancer by showing their loss leads to lineage infidelity and reactivation of lactation programs.

The paper distinguishes MSH2-MSH3 and MSH2-MSH6 mismatch interactions using a high-throughput FRET system based on ATP-bound sliding clamp stability.

The paper identifies early alpha cell dysfunction in individuals with GADA+ status, preceding beta cell loss in T1D, and links it to metabolic pathway abnormalities.

This study develops an AI-driven multi-resolution simulation workflow to study SARS-CoV-2 RTC dynamics, combining cryo-EM with mesoscale simulations and AI methods.

This study uses a semi-synthesis approach to generate N-terminal acetylated HMGB1 proteins and shows that this modification affects its interaction with heparin and stability.