J. Liu

This study shows that CD147 antibody inhibits SARS-CoV-2 infection and cytokine storm in variants by blocking viral entry and reducing inflammatory responses.

This paper identifies a monoclonal antibody, 2G1, that neutralizes all SARS-CoV-2 variants with high potency and describes its mechanism of action and therapeutic efficacy in animal models.

This study constructs a prognostic model for AML using multiomics data to identify immune-related biomarkers and classify patients into subtypes with different survival outcomes.

This study uses single-cell sequencing to analyze immune responses in acute Kawasaki disease before and after treatment, identifying key gene expression changes and immune cell dynamics.

This study identifies molecular aberrations in normal breast tissue from high-risk women, linking epigenetic and transcriptional changes to breast cancer susceptibility.

This study evaluates the protective efficacy of oral SARS-CoV-2 delivery in rhesus macaques against respiratory challenges, finding limited immunogenicity and partial protection.

The paper assesses the neutralization ability of BNT162b2-elicited sera against SARS-CoV-2 variants, finding that all sera neutralize variants to titers of ≥80, indicating vaccine effectiveness against emerging strains.

This study shows that immunization with different SARS-CoV-2 variant spikes leads to varying neutralizing kinetics and magnitudes against other variants, with significant differences in titers between homologous and heterologous variants.

The paper shows that the ParABS system operates near a critical point to ensure accurate plasmid segregation in bacteria by adapting to cell size and buffering fluctuations.

This study uses cryo-electron tomography and deep learning to visualize the molecular organization of nucleosome phase separation stages, revealing a two-step process and the role of histone H1 in condensate transformation.

This study shows that dietary methionine restriction worsens cancer growth and reduces anti-tumor immunity via gut microbiota and immune suppression in immunocompetent mice.

The paper compares vaccine efficacy against Delta and Lambda SARS-CoV-2 variants, finding Lambda has greater escape potential, with reduced antibody reactivity and therapeutic antibody binding.

The paper introduces a universal microfluidic method for studying bacterial biofilms, demonstrating insights into H2O2 resistance and resource retention mechanisms in E. coli and P. aeruginosa biofilms.

This study characterizes the flagellar collar in Borrelia burgdorferi, revealing its structural plasticity and essential role in spirochete motility through high-resolution in-situ structures.

This study develops a single-dose rAAV5-based vaccine that provides long-term immunity against SARS-CoV-2 and its variants with high neutralizing antibody titers and safety.

The paper establishes a bacterial genome and culture collection of the piglet gut microbiome, revealing new species and functional insights.

This meta-analysis evaluates the effect of 0.01% atropine on axial elongation in myopic children using orthokeratology, finding it significantly reduces axial elongation.

This paper evaluates four commonly used murine models of atrial fibrillation and finds they do not exhibit authentic AF characteristics, such as micro-reentrant circuits or typical ECG features.

This study compares two mRNA SARS-CoV-2 vaccines in nonhuman primates, showing that CV2CoV, with optimized non-coding regions, provides better immune responses and protection than CVnCoV.

This study compares a wild-type SARS-CoV-2 spike protein DNA vaccine with an optimized sequence in a mouse model, showing enhanced immune responses and protection against viral challenge.

The paper develops a framework to quantify DOM-microbe associations under global change, finding that molecular traits and nutrient enrichment influence these interactions differently in subarctic and subtropical climates.

This study identifies the P681R mutation in the Delta variant's spike protein as critical for enhanced viral replication compared to the Alpha variant through increased furin cleavage of the spike protein.

The paper shows warmer temperatures during the previous growing season advance spring phenology in the Northern Hemisphere, with a decline in this effect over time.

This paper develops a novel PROTAC, ZL216, using an aptamer as a targeting ligand to selectively degrade nucleolin in breast cancer cells, inhibiting their proliferation and migration.

This study uses single-cell RNA-sequencing to characterize human dura and meningioma, revealing distinct immune microenvironments and TCR overlap between matched samples.

This study shows that STAT3 deficiency in dendritic cells leads to colitis in mice, which is dependent on the gut microbiome.

The paper uses thermodynamic models to show that higher-order cooperativity between transcription factors drives transcriptional repression in a synthetic enhancer.

The paper introduces a mass spectrometry platform combining acoustic droplet ejection, open-port interface, and electrospray ionization for high-speed, label-free analysis across multiple applications.

This study identifies rhizosphere metabolites and microbial shifts in alfalfa soils under continuous cropping, showing autotoxic substances like p-coumaric acid contribute to crop obstacles.

The paper identifies key glucosyltransferase and glucuronosyltransferase enzymes in Scutellaria baicalensis and shows how SbUGAT4 contributes to the high accumulation of baicalin in root tissues.