J. Park

The paper identifies ribosome biogenesis and endomembrane expansion as key drivers of C. elegans anchor cell invasion through basement membrane using transcriptomic and functional analyses.

This study shows that Cdkn2a regulates beige fat maintenance via BECN1-mediated autophagy, with implications for obesity and diabetes treatment.

The paper constructs a multimodal tumor metabolism atlas to identify gene-metabolite co-regulation patterns across cancer types.

This study engineers IsPETase to balance PET hydrolysis activity and thermostability, resulting in a variant that outperforms existing variants in depolymerization efficiency.

This study analyzes single-cell transcriptomes of gastroenteropancreatic neuroendocrine tumors to identify lineage diversity and immunosuppressive programs in tumor and immune cells.

This study identifies PODXL as a decoy receptor for GAL3, revealing its role in promoting metastasis through integrin-based invasion and differential cortical targeting regulated by ubiquitination.

The paper examines long-term effects of SARS-CoV-2 infection on low-density granulocytes (LDGs) in individuals with chronic pulmonary symptoms, finding elevated LDG levels and activation markers.

This paper introduces TIM-OCT, a tunable imaging technique that provides high resolution in either lateral or axial dimensions or across all dimensions, and demonstrates its application on biological samples.

The paper approximates fixation probability in finite population evolutionary games using Bernstein polynomials, showing better efficiency in strong selection regimes.

This study shows that PER phosphorylation inhibits CK1 activity, stabilizing PER and extending circadian period through feedback inhibition.

The paper develops Per1-luc and Per2-luc reporter cell lines to study circadian mechanisms and uncover differences between Per and Cry paralogs.

This paper develops a stochastic model to study adaptive chemotherapy's impact on tumor sub-populations and shows that resistant sub-populations grow with increasing control parameters.

The paper shows that inhibiting endocytosis with fasudil increases Fas microaggregate formation, making cancer cells more sensitive to FasL-induced apoptosis.

This paper introduces a hydrogel-based method for long-term label-free 3D imaging of live bacteria, enabling precise analysis of biophysical parameters and antibiotic responses.

This study identifies VNTRs as modifiers of breast cancer risk in BRCA1 185delAG carriers, finding several VNTRs significantly associated with earlier age of onset compared to SNPs.

This study identifies KDM4A as a key driver of neuroendocrine prostate cancer progression and shows that targeting KDM4A inhibits tumor growth in preclinical models.

This paper shows that MYC overexpression in cancers suppresses immune surveillance by inhibiting pro-inflammatory macrophages, and this immune evasion can be reversed by combined PDL1 and CTLA4 blockade.

The paper identifies kinesin adaptors that mediate spectrin transport and lattice expansion during axon stretch-growth.

This study shows that transcranial focused ultrasound can induce both suppressive and excitatory responses in an epilepsy model, depending on stimulation parameters.

This study compares high- and low-level deep learning approaches for microsatellite instability prediction using TCGA data, finding the high-level approach superior and identifying key morphological features.

The paper withdraws due to the need for further experiments to validate conclusions about Bfl-1 and HDAC inhibition in diffuse large B cell lymphoma.

The paper visualizes the tubulin folding pathway mediated by TRiC using cryoEM, showing how TRiC's structure guides the folding of β-tubulin through specific interactions.

The paper defines the high-resolution timeline of secretory vesicle formation and fusion in S. cerevisiae, revealing the ordered recruitment and release of key components.

The paper generates a high-quality little skate genome and analyzes motor neuron gene regulation across species to identify conserved and divergent mechanisms in vertebrate locomotion evolution.

The paper develops a platform for multi-scale molecular imaging and phenotyping of the human brain, integrating novel tools for tissue processing, imaging, and computational reconstruction.

This study shows intermittent fasting activates AMPK in rodent PAH models, improving RV lipid metabolism, mitochondrial function, and microtubule structure.

The paper measures dissolved siderophore concentrations and types in the North Pacific Ocean, linking their distribution to microbial activity and environmental factors.

The paper presents a high-resolution structure of the S1P5 receptor complexed with an inverse agonist, revealing structural features that explain receptor subtype selectivity and inverse agonism.

This paper introduces a new sample delivery method for serial femtosecond crystallography, enabling reliable crystal deposition and successful structure determination of lysozyme.

This study identifies bi-steric mTORC1-selective inhibitors that reactivate 4EBP1, suppress MYC-driven tumors, and enhance immunotherapy in multiple cancer models.