J. Tang

This study examines how dietary fiber affects gut microbiome dynamics and SCFAs in mice, showing baseline-dependent responses and the importance of ecological modeling.

This study identifies AOAH as a lipase that deacylates oxidized phospholipids, reducing inflammation and acute lung injury in vivo.

This study identifies non-coding NFKBIZ 3' UTR mutations as drivers of DLBCL growth and resistance to NF-κB-targeted therapies, suggesting their potential as biomarkers.

This study shows that PANX3 deletion reduces fat mass and inflammation in male mice but not females, with male KOs having fewer adipocytes and lower inflammatory gene expression.

The paper analyzes gene expression changes in hiPSC-derived cardiomyocytes using single-cell RNA-seq, identifying key genes that mark differentiation stages and sources of variation across protocols and cell lines.

This study evaluates the neutralization capacity of hyperimmune immunoglobulins and convalescent plasma against SARS-CoV-2 and its variants, finding reduced effectiveness against certain variants with hCoV-2IG showing better cross-neutralization than convalescent plasma.

This study shows that young and undamaged recombinant mouse serum albumin (rMSA) extends the lifespan and healthspan of C57BL/6N mice by 17.6% and 20.3% respectively.

This study investigates the role of the abaI/abaR quorum sensing system in Acinetobacter baumannii virulence, showing its impact on growth, biofilm formation, antimicrobial susceptibility, and gene expression.

The paper describes a novel Thermoleptolyngbya strain, identifies it as a new species using phylogenetic and genomic analyses, and explores its genomic features and adaptive capabilities.

The paper identifies GRL0617 as a non-covalent inhibitor of SARS-CoV-2 PLpro with an IC50 of 2.1 μM, supported by co-crystal and NMR data showing its mechanism of action.

This study identifies nucleolin as essential for RHDV replication by facilitating the formation of replication complexes through interactions with viral proteins.

This study evaluates antibody responses to different SARS-CoV-2 spike protein antigens in rabbits, finding that the RBD antigen elicited higher affinity and titer neutralizing antibodies.

This study shows that culturing murine BMSCs under hypoxia reduces hematopoietic contamination and increases stromal cell population.

This paper develops a high-speed, contrast-free ultrasound velocimetry technique for quantifying blood flow velocity in rodent brains and validates it through simulations, phantoms, and in vivo experiments.

This study identifies sPML-II as the isoform that inhibits PRV infection by suppressing viral gene transcription through its 7b region.

This study develops dihydroartemisinin-loaded magnetic nanoparticles to enhance chemodynamic therapy, showing improved ROS production and efficacy against breast cancer cells, including drug-resistant ones.

This study shows that downregulating GPR183 in macrophages during Mtb infection limits bacterial survival, while overexpression or ligand stimulation promotes it.

This study investigates how mixed-species malaria parasite infections in mice and mosquitoes affect disease severity, parasite fitness, and transmission success.

This paper demonstrates that expressing eight immunomodulatory genes in mouse embryonic stem cells enables them to avoid immune rejection and form immune-privileged tissues in allogeneic hosts.

This paper introduces dynamic laser speckle imaging (DLSI) to quantitatively measure light scattering dynamics and demonstrates its application in cerebral blood flow imaging in mice.

This paper shows that isomerization of long-lived proteins in Alzheimer’s disease prevents lysosomal digestion, leading to lysosomal failure and linking AD to lysosomal storage disorders.

This paper optimizes DNA extraction from human urine to better profile both bacterial and fungal communities using next-generation sequencing.

The paper compares nitrogen allocation in leaves of nitrogen-fixing and non-nitrogen-fixing tree species, finding lower photosynthetic nitrogen use efficiency in nitrogen-fixing species due to reduced allocation to Rubisco and bioenergetics.

This study evaluates molecular residual disease in AML patients during chemotherapy, finding stable variant allele frequencies that may indicate limited therapeutic response.

This study shows Bclaf1 is degraded by alphaherpesvirus US3 and is critical for type I interferon signaling and antiviral immunity.

This paper introduces HIST, a microscopy technique that improves imaging area and beam thickness for single-molecule imaging in cells and tissues.

This paper introduces flat-field illumination to improve uniformity in fluorescence microscopy, enabling multi-color single-molecule imaging with minimal image overlap.

This study introduces a single-molecule pull-down assay to count and analyze endogenous α-SYN protein oligomerization in human brain tissues.

This paper introduces a reflective imaging technique that enhances resolution, speed, and collection efficiency in light sheet microscopy without altering the microscope hardware.