J. Wang

The paper examines antibody responses to SARS-CoV-2 variants, finding convergent epitope specificities, V gene usage, and public B cell clones across different variants.

The paper develops a multiplexed in vivo approach to identify driver genes in SCLC using CRISPR/Cas9 and lentiviral barcoding, finding TSC1 as a robust tumor suppressor.

This study implants graphene quantum dots in PEGylated nanoparticles to enhance in vivo imaging and tumor detection, showing improved circulation and tumor accumulation.

This study identifies m6A modification patterns and functions during sexual reproduction in Chlamydomonas reinhardtii, showing its role in regulating microtubule-based processes.

The paper uses Oxford Nanopore sequencing to generate six gastropod mitochondrial genomes as part of a biodiversity curriculum, demonstrating its utility for hands-on genomics training.

This study shows that targeting AKAP12 phosphorylation in HSCs reduces liver fibrosis by inhibiting collagen maturation and HSC activation in mouse models.

The paper develops a platform for multi-scale molecular imaging and phenotyping of the human brain, integrating novel tools for tissue processing, imaging, and computational reconstruction.

The paper simplifies a cardiac hERG ion channel model using MBAM, reducing parameters and states while retaining predictive capability, improving parameter identifiability.

The paper was withdrawn due to lack of author consent and is not intended for citation.

The paper shows that thyroid hormone induces BAFF overexpression, leading to abnormal B cell differentiation in Graves disease.

This study identifies Ruminococcus gnavus as a gut bacterium that contributes to IBS-D by increasing serotonin biosynthesis through phenethylamine production.

This study shows NAC1 suppresses regulatory T cell-mediated tolerance by deacetylating and destabilizing FoxP3, leading to autoimmunity, and suggests targeting NAC1 could treat autoimmune disorders.

The paper shows Lin28b programs neonatal CD8+ T cells to have innate defense capabilities through transcriptional and epigenetic changes.

This study demonstrates that MYCN and BCL2 enhance interspecies chimerism with human pluripotent stem cells, enabling the generation of functional human blood progenitor cells in chimeric embryos.

This study identifies a unique phosphonate utilization mechanism in diatom Phaeodactylum tricornutum involving uptake via clathrin-mediated endocytosis and incorporation into membrane phospholipids.

This paper develops a biparatopic nanobody with broad neutralization against multiple SARS-CoV-2 variants, including Omicron, showing strong affinity and activity.

This study uses deep learning to infer 3D genome organization from ancient DNA, revealing how chromatin folding influenced phenotypic and sequence divergence between Neanderthals, Denisovans, and modern humans.

This study shows that BA.2 causes stronger antibody evasion than BA.1, particularly in SARS convalescents, and identifies key mutations responsible for this escape.

The paper identifies IMC proteins in Plasmodium yoelii and shows DHHC2 palmitoylates CDPK1 and GAP45 for their localization, essential for schizont development.

The paper uses transcriptomics and phenomics to identify genes involved in biofilm formation and regulation in Synechococcus elongatus PCC 7942 and compares the effectiveness of these approaches.

This paper designs and characterizes lipid nanocarriers for oral delivery of immunotherapeutic peptides, showing they are non-toxic, taken up by immune cells, and accumulate in lymph nodes.

This study examines the P132H mutation in Omicron SARS-CoV-2 Mpro, finding it reduces thermal stability without affecting catalytic activity or drug inhibition.

This study shows that the LPS-TLR4 pathway promotes NETs formation in AACLF, exacerbating liver injury through mechanisms involving gut-derived LPS and neutrophil activity.

This study identifies the EMC complex's role in regulating intestinal stem cell proliferation via the Hippo pathway in Drosophila, showing its negative regulation and evolutionary conservation.

This study uses single-cell and spatial transcriptomics to analyze heterogeneity and immunosuppressive microenvironment in human SCLC, identifying hybrid tumor cell states and their origins.

The paper screens FDA-approved drugs to find inhibitors of NDM-1, restoring carbapenem efficacy against resistant bacteria.

The paper identifies ASGR1 as a potential receptor for SARS-CoV-2 that facilitates liver cell infection and suggests soluble ASGR1 as a therapeutic target.

This study develops allogeneic gene-edited HIV-specific CAR-T cells secreting PD-1 blocking scFv, showing enhanced anti-HIV activity in vitro compared to autologous CAR-T cells.

The paper introduces a rapid, highly multiplexed protein detection method for brain tissue, enabling simultaneous detection of 31 proteins in 2 hours with high sensitivity and resolution.