J. Wang

The paper determines the cryo-EM structure of MgtE in Mg2+-free conditions, revealing cytoplasmic pore opening and kink motions in TM2 and TM5 helices.

This study shows miR-224 promotes HCC cell migration and invasion by targeting HOXA5 and ADAM17, suggesting it as a potential therapeutic target.

This study identifies a transitional cancer cell state in metastatic pancreatic cancer and shows that tumor microenvironment signals drive transcriptional plasticity and subtype transitions.

This study shows that reducing the peroxisomal enzyme Ehadh in hepatoblastoma makes tumors more susceptible to a fatty acid metabolite, suggesting a potential metabolic therapy.

This paper identifies a novel allele of the chromogen gene C from wild rice that regulates anthocyanin biosynthesis differently in indica and japonica subspecies.

St. Jude Cloud provides a genomic data sharing ecosystem for pediatric cancer research, offering access to over 10,000 patient genomes and enabling analysis of cancer subtypes and mutational signatures.

This paper investigates how SARS-CoV-2 NSP1 inhibits translation initiation by competing with mRNA for binding to the 40S ribosomal subunit, modulated by eIFs.

This paper introduces a rapid screening system to identify potent neutralizing antibodies against SARS-CoV-2 and demonstrates its effectiveness in discovering high-potency antibodies.

This study develops a cell-based chimeric vaccine against SARS-CoV-2 that induces strong T cell immunity and neutralizing antibodies without toxicity.

The paper investigates whether P-elements strengthen reproductive isolation between Drosophila simulans and its sister species by analyzing hybrid fecundity in crosses with differing PE status.

The paper determines the structural architecture of the plant TSET complex and identifies key interactions essential for its assembly and function in endocytosis.

This paper develops membrane nanoparticles from ACE2-rich cells that effectively block SARS-CoV-2 infection by trapping the viral S1 protein and inhibiting its interaction with host cells.

This study shows that the bacterial QS molecule DSF suppresses Arabidopsis innate immunity by altering sterol biosynthesis and disrupting FLS2 receptor dynamics.

This study shows that MGMT genomic rearrangements cause TMZ resistance in gliomas and can be detected in exosomes as potential recurrence markers.

This study compares the gut DNA and RNA viromes of Chinese residents and Pakistani visitors, finding ethnic origin significantly influences virome composition and diversity.

This paper identifies genes in Staphylococcus aureus that influence phage host range by analyzing strain sensitivity to phages and associating genome sequences with host range.

This study develops a virus-free live-cell visualization system for SARS-CoV-2 entry using a fluorescent spike trimer probe, enabling analysis of neutralizing antibodies and inhibitors.

This study shows that deleting Nupr1 in HSCs activates quiescence, enhancing engraftment without affecting stemness or differentiation.

Pep-GaMD improves simulation of peptide binding by enhancing sampling and calculating free energies and kinetics with better accuracy and efficiency than conventional methods.

This study identifies calumenin (CALU) as a marker of poor prognosis in glioma, showing its association with epithelial-mesenchymal transition and malignant phenotypes.

This study compares the DNBSEQ-G400 and Illumina MiSeq platforms for metabarcoding fungal communities, finding DNBSEQ-G400 to be more accurate, less biased, and cost-effective.

This paper shows that recombinant Bacillus subtilis spores expressing H. contortus GAPDH protect sheep from infection by boosting immune responses and reducing parasite burden.

This paper creates a single-cell transcriptomic atlas of the Chinese horseshoe bat to study its role as a viral reservoir, identifying cell types and receptor expression patterns related to viral entry.

This study shows that inhibiting KDM5 demethylases restores H3K4 methylation and reactivates genes in KMT2D mutant lymphomas, offering a potential therapeutic strategy.

This study investigates the effect of hydrogen inhalation on SIgA, PIgR, and cytokines in a COPD rat model, finding improved expression of SIgA and related factors with higher hydrogen concentrations.

This study shows that active integrins regulate white adipose tissue insulin sensitivity and brown fat thermogenesis through interactions with the insulin receptor.

This paper models adhesive interactions between cylindrical and spherical viral particles and a cell membrane, showing conditions under which adhesion occurs or is prevented without external force.

B cells integrate innate TLR and adaptive CD40 signals to induce BATF3 transcription factor for production of IL-27, which together with INFg optimizes antibody responses.

This study identifies IKBIP as an EMT-related biomarker associated with poor survival in glioma, showing its correlation with aggressive phenotypes and key EMT markers.

This study identifies miRNAs other than miR-122 that support HCV replication in non-hepatic cells by interacting with the viral 5UTR and stabilizing the IRES structure.