J. Wang

This study uses chemoinformatics to engineer polyketide synthases for producing saturated β-carbon compounds, finding a correlation between chemical similarity and product titers.

This study develops a vaccine candidate against SARS-CoV-2 using virus-like particles displaying the receptor binding domain, which induces neutralizing antibodies in mice.

This study investigates tree shrew susceptibility to SARS-CoV-2 infection and finds that they show mild symptoms and low viral replication, suggesting limited susceptibility.

This study introduces the M. tuberculosis-specific gene pair into M. kansasii to model pathoevolution, finding that 1-TbAd production enhances early infection but impairs long-term survival.

This study establishes a BRBV replicon system and identifies myricetin as a potent inhibitor of BRBV replication with a high therapeutic index.

The study identifies microbial communities associated with ECM Russula symbiosis and sporocarp production in Fagaceae plants in southern China.

This study identifies PKD-2-carrying ciliary EVs as mechanoresponsive and directionally transferred in C. elegans, suggesting conserved mechanisms across species.

This study shows that antibodies from SARS-CoV survivors and immunized animals neutralize SARS-CoV-2, suggesting potential for broad-spectrum vaccines against emerging coronaviruses.

This paper introduces LiGaMD, a method to accelerate ligand binding simulations, showing accurate thermodynamics and kinetics compared to experiments.

This paper develops a novel cancer therapy called gene interfered-ferroptosis therapy (GIFT) that selectively induces ferroptosis in cancer cells while sparing normal cells.

This study identifies RSH-1 as a lysosomal NADPH phosphatase that regulates ER proteostasis via mTOR signaling in C. elegans.

This study identifies a structural element in rabbit Fab light chains that hinders human Fab crystallization and presents a modified 'Crystal Kappa' design to improve crystallization efficiency.

This study identifies humanized single domain antibodies that neutralize SARS-CoV-2 by targeting the spike receptor binding domain, showing improved activity when fused with the Fc region.

This paper shows that co-activation of NF-κB and MYC in cancer cells makes them dependent on IL6 for survival and leads to a poorly-differentiated state similar to human plasmablastic lymphoma and t(8;14)[MYC-IGH] multiple myeloma.

The paper identifies CREBBP/EP300 as radiosensitization targets in mutant tumors by inhibiting histone acetyltransferase, which represses homologous recombination and increases radiation sensitivity.

The paper identifies noncoding RNA-encoded proteins on lipid droplets, discovering LDANP1 which modulates lipid metabolism and insulin sensitivity.

This study creates a single-cell transcriptome atlas of a non-human primate to explore SARS-CoV-2 targets and immune responses, identifying potential therapeutic targets and mechanisms linking IL6 to viral entry.

The paper shows that the EPHA2-ROBO1 heterodimer reduces growth of lung and head and neck squamous cell carcinomas and suggests SLIT2 and Ensartinib as potential therapies.

This study compares SARS-CoV-2 infection outcomes in three non-human primate species, finding that M. mulatta is most susceptible, followed by M. fascicularis and C. jacchus.

This paper develops freeze-dried PCR mixes for SARS-CoV-2 detection that can be stored at room temperature, maintaining sensitivity and specificity for up to 28 days.

The paper shows that inhibiting nonsense-mediated decay increases expression of p53β/γ isoforms, which are resistant to MDM2 degradation, thereby restoring p53 function in cancers with MDM2 amplification, HPV infection, or specific p53 mutations.

This paper introduces a novel MRI/MRS method that selectively images specific metabolites by using nuclear spin singlet states, demonstrating molecular selectivity for endogenous molecules like N-acetylaspartate and dopamine.

The paper shows MDCK cells coordinate collagen I fiber assembly through motion, promoting branching morphogenesis, with cell contraction and actin cytoskeleton playing key roles.

This study evaluates how well 27 crop modeling groups predict wheat phenology in Northern France using calibration data from the same target population, finding mean absolute errors comparable to measurement error.

This paper combines CIS checkpoint deletion with CAR engineering in NK cells to enhance their metabolic fitness and anti-tumor activity in a lymphoma model.

The paper investigates how lectin-like intestinal defensin HD5 inhibits 2019-nCoV Spike protein binding to ACE2, showing a high-affinity interaction and protective effect in vitro.

The paper develops CAR-expressing iPSC-derived macrophage cells with antigen-dependent anti-cancer functions effective against both liquid and solid tumors.

The paper establishes TurboID as the most effective PDL method in plant systems and demonstrates its utility in capturing protein interactomes and structural information.

This paper develops a bio-active scaffold combining HMGB1 and kartogenin to enhance meniscus healing, showing activation of stem cells and promotion of tissue repair in vitro and in vivo.

This study designs, synthesizes, and evaluates two peptidomimetic aldehydes as antiviral drug candidates targeting SARS-CoV-2 main protease, showing potent inhibition and anti-infection activity.