J. Wang

The paper introduces PACPIC, a method using phase separation to identify direct and indirect protein-protein interactions in cells by recruitment as a readout.

This paper develops a mechanochemical model to study how cell tension affects migration, showing it inhibits movement under persistent stimuli but can enhance migration under random noise.

This study expresses, purifies, and functionally reconstitutes 19F-labeled cytochrome b5 in peptide nanodiscs to enable NMR studies of its transmembrane domain interactions with CYP2B4.

This study demonstrates that transient expression of Runx1 and Hoxa9 in pluripotent stem cells generates functional T cells capable of immune surveillance and tumor eradication.

The paper presents a large multi-omic cohort of 2,183 adults to identify correlations between gut microbiome features and various health-related factors, validated in an additional cohort.

The paper investigates how peripheral mutations in CYP1A2 affect substrate channel dynamics using computational models, finding that some mutations disrupt water channels and substrate binding.

This study examines how hearing sensitivity changes with age in red-eared slider turtles, finding frequency-specific developmental patterns and age-related shifts in auditory thresholds.

The paper presents a method combining global peptide docking and accelerated molecular dynamics simulations to improve peptide-protein binding predictions, achieving high-quality models for some cases.

This study examines genomic variation across four Populus species to show that selection and genomic features shape patterns of diversity and divergence during speciation.

The paper assembles over 56,000 metagenome-assembled genomes from oral microbiome samples, revealing new taxa and biomarkers for diseases.

The paper identifies CbuSPL9 and its interacting protein CbuHMGA in Catalpa bungei, showing they form a heterodimer and may regulate flowering development, not transition.

This study shows invasive Zaprionus indianus populations have lower genetic diversity than native populations but maintain higher diversity than non-invasive species, and exhibit a broad thermal niche with no performance difference between invasive and native populations.

This paper identifies model organisms for studying ALK and LTK proto-oncogenes by analyzing their evolutionary history and ligand homology across species.

This study shows that cargo-free scaffolds recruit metastatic cancer cells through a lung-mimicking myeloid cell S100A8/A9 axis, reducing lung metastasis.

This study investigates changes in mechanical properties and nanomorphology of BMSCs during early apoptosis using AFM and other techniques, finding that mechanical damage precedes apoptotic signals.

This study constructs large-scale, morphologically controlled λ-DNA networks using a DC electric field and investigates factors affecting their structure.

The paper develops an in vitro model called Mipro that maintains gut microbiome functional and compositional profiles, showing strong correlation with in vivo responses to metformin.

The paper uses integrated proteomic and metabolic single-cell assays to identify two distinct adaptive pathways in BRAF-mutant melanoma cells during drug treatment.

This paper demonstrates that CRISPR-Cas9-assisted native end-joining editing can efficiently knock out large genomic regions in E. coli without exogenous repair systems.

The paper identifies deamidation at Asn-358 in moxetumomab pasudotox causing conformational changes and reduced immunotoxin activity.

The paper investigates the inverse relationship between fibronectin and neuroligins in the embryonic rat colon, showing direct regulation and negative correlation.

This study analyzes the vagino-cervical microbiome of 516 women using metagenomic shotgun sequencing to explore how pregnancy, delivery, and contraception influence microbiome composition.

The paper uses computational modeling to reveal a hydrophobic force-induced mechanism for pore formation in cholesterol-dependent cytolysins.

This study uses GaMD simulations to show that A1AR activation state affects its interaction with lipid bilayer, revealing coupled dynamics between the receptor and membrane.

This paper introduces CLEAR-dPCR, a lossless and contamination-free digital PCR technology that improves accuracy and dynamic range compared to existing platforms.

The paper analyzes oral microbiome data from the Earth Microbiome Project to show its distinct composition, lower diversity, and environmental correlations.

The paper identifies dysbiosis in RA tonsillar microbiota and shows that Streptococcus salivarius and its antibacterial peptides modulate autoimmunity by suppressing T cells and autoantibodies.

This study shows that engineering CAR-T cells with CD103 improves their anti-tumor efficacy against E-cadherin positive tumors by enhancing infiltration, expansion, and persistence in vivo.

PIRD is a database that collects and stores annotated TCR and BCR sequencing data, along with tools for visualization and analysis.

The paper examines 3D chromatin changes in T-ALL, identifies TAD fusion events linked to oncogene activation, and shows drug treatments can restore some interactions.