J. Wang

The paper uses MD simulations to study ligand transport by P-gp and shows lipids also play a role in this process.

This study identifies 28 dysregulated hepatic miRNAs in C57BL/6 mice infected with Echinococcus multilocularis eggs, showing downregulation of miRNAs involved in angiogenesis and fatty acid biosynthesis.

This study shows that calorie restriction leads to BMI loss in nonobese individuals, with variations linked to gut microbiota enterotypes.

This study identifies a comprehensive atlas of B-lymphocytes in triple-negative breast cancer using single-cell RNA-sequencing and antigen receptor profiling, revealing their mature characteristics and prognostic significance.

The paper performs single-cell RNA sequencing on TNBC tumors to identify novel immune cell subsets and their associations with survival and TCR signaling.

This study evaluates how golden apple snail residues affect soil properties and bacterial communities, finding that they increase soil nutrients and alter bacterial diversity and composition.

This study identifies the C-terminal non-catalytic domain of Mkp-1 as containing multiple elements that mediate its rapid proteasome-dependent degradation in enterocytes, independent of ERK phosphorylation.

This study shows that microbiota community structure across various host organisms aligns with neutral model predictions, suggesting neutral processes rather than host selection primarily shape microbial communities after colonization.

This paper introduces CATE-seq, a CRISPR-based targeted sequencing method that outperforms hybridization-based techniques in simplicity, specificity, sensitivity, throughput, and scalability.

The paper introduces tidyNano, an R package for analyzing nanoparticle data, and applies it to study murine placental extracellular vesicles across gestation and preterm birth.

SPIKEPIPE accurately quantifies eukaryotic species abundances using DNA barcodes or mitogenomes with high accuracy and repeatability across environmental samples.

The paper compares gut metagenomics and metaproteomics in prediabetics and treatment-naïve type 2 diabetics to identify host-microbial interplays across disease stages.

The paper analyzes gene panel sequencing data from 829 Chinese high-risk breast cancer patients to identify pathogenic variants and variants of uncertain significance across 115 hereditary cancer susceptibility genes.

The paper identifies IL-24 as an anti-apoptotic factor in liver ER stress, showing its role in preventing cell death and its clinical relevance in acute liver failure.

This study uses single particle cryo-EM to determine the structure of 52 kDa streptavidin at 3.2 Angstrom resolution, demonstrating the feasibility of high-resolution imaging for small molecules.

This study investigates how HER2 dynamics in filopodia regulate protrusion growth and signaling in breast cancer cells, revealing distinct motion patterns and functional roles in protrusion-based signaling.

This study evaluates the effects of five products on gut microbiota and short-chain fatty acids in obese rats, finding that some products increase microbial diversity and SCFA levels.

The paper presents a MALDI-TOF MS method to detect ovarian cancer progression using vaginal fluid samples from tumor-bearing mice.

The paper identifies epigenetic drivers of esophageal squamous cell carcinoma through multi-omics analysis, revealing hypomethylation patterns and non-canonical WNT signaling activation.

This study identifies adaptable retromer structures and their role in cargo sorting from endosomes to the TGN or plasma membrane in mammals.

This study shows that the SIK3 inhibitor YKL-05-099 suppresses MEF2C function and slows AML progression in mouse models.

The paper reports a quadruple mutant of hepatitis B virus showing moderate resistance to tenofovir and demonstrates that combination therapy with entecavir and tenofovir effectively suppresses this resistant mutant.

The paper identifies intron retention as a hallmark of aggressive prostate cancer and highlights the spliceosome as a therapeutic target by analyzing splicing dysregulation across prostate cancer progression.

This study adapts base editors to Streptomyces, achieving high-efficiency genome editing without DNA double-strand breaks.

The paper compares transcriptome profiles of maize CSSLs I178 and X178 under accelerated ageing to identify genes and alternative splicing events associated with seed longevity.

The paper creates a gene catalog of bovine rumen microbes, revealing high diversity and function in plant biomass degradation and methane production.

This study introduces E. faecalis strains into neonatal rats and finds that some strains increase necrotizing enterocolitis pathology.

This study characterizes the parasitic effect of Phanerochaete chrysosporium strain B-22 on Meloidogyne incognita life stages and demonstrates its efficacy as a biocontrol agent for tomato plants.

This study analyzes TCR repertoires in RA patients and identifies clonal expansion and shared repertoires between EMT and Th17 cells, correlating TCR diversity with disease activity.

This paper reports the crystal structure of the HCMV UL144/BTLA complex, revealing molecular mechanisms of selective BTLA binding and informing the design of BTLA agonists.