J. Wu

This study shows that blocking CTLA-4 reverses Treg cell suppression of anti-TB T-cell responses in tuberculosis patients.

The paper identifies low-molecular-weight drugs that inhibit SARS-CoV-2 main protease using a fragment-based approach, finding niacin and hit 1 bind to the catalytic pocket and leading to the discovery of four drug candidates.

This paper investigates the ligand recognition mechanism of PHF20L1 Tudor1, revealing a pre-existing open conformation that enables binding to both methylated proteins and small molecules.

This study shows Mg2+ promotes bone regeneration initially by modulating macrophage activity but later inhibits bone formation through NF-κB activation and reduced hydroxyapatite precipitation.

This study identifies ACE2 orthologs from diverse species that can support SARS-CoV-2 entry, suggesting a broad host range for the virus.

The paper identifies Linc00402 as a novel lncRNA regulating allogeneic T-cell responses through RNA-seq analysis of human T-cells post-HSCT.

This study evaluates the toxicity of miR-874 antagomiR and miR-146a in cardiomyocytes and cardiac fibroblasts, finding no significant effects on caspase activity or Ca2+ levels but potential impacts on MMP9 expression.

ClonArch visualizes the spatial clonal architecture of tumors by integrating phylogenetic trees and spatial data to examine intratumor heterogeneity.

This study identifies Paxillin's role in promoting ATP-induced activation of P2X7 receptor and NLRP3 inflammasome through complex formation and deubiquitination.

This study investigates how aging impacts immune-myoblast communication during muscle repair, finding that old bone marrow impairs myogenesis by inhibiting myoblast proliferation.

The paper presents a molecular typing method for respiratory adenoviruses using universal PCR and sequencing primers for three capsid genes, enabling rapid identification of HAdV types and recombinants in clinical samples.

This study investigates the role of reactive oxygen species (ROS) in plant cell division and cold stress adaptation, finding that ROS influence cell wall stiffness and regulate division rates in Brassica napus.

The paper identifies broadly neutralizing antibodies against HBV in elite neutralizers and shows that combinations of bNAbs targeting different epitopes are more effective than single bNAbs.

This paper validates a vascularized micro-tumor model for colorectal cancer that better replicates in vivo drug responses than traditional 2D or 3D models.

The paper uses cryo-EM to reveal the post-fusion structure of SARS-CoV-2, showing the S protein in a state with S1 disassociated.

This study identifies a non-hypermucoviscous ST11 hypervirulent K. pneumoniae strain lacking classical virulence factors, showing increased virulence through ampR and WcaJ mechanisms.

This study shows artesunate interacts with the vitamin D receptor to reverse sepsis-induced immunosuppression by enhancing autophagy and modulating NF-κB activity.

OsNLP1 rapidly responds to nitrogen availability, enhances nitrogen uptake and assimilation, and holds great potential in promoting high yield in rice.

This study shows that knocking out rice OsPQT3 enhances resistance to abiotic stresses and increases grain yield under salt stress conditions.

This paper introduces VasNet, an unsupervised learning algorithm that improves vascular disease diagnosis from unlabeled images by focusing on retinal vasculature features.

This study identifies ATI1 and ATI2 as cargo receptors for MSBP1 in a starvation-induced ER-phagy pathway in Arabidopsis, distinct from ER-stress-induced pathways.

This study identifies new epigenetic and genetic biomarkers for esophageal cancer using cfDNA and combines SALP-seq with machine learning.

This study identifies OsNLP4 as a master regulator of nitrogen use efficiency in rice, showing it improves yield and NUE through transcriptional regulation of nitrogen-related genes.

The paper introduces a microtubule probe that enables correlative super-resolution fluorescence and electron microscopy to study microtubule ultrastructure.

This study identifies miR-574 as a regulator of FAM210A, which influences mitochondrial protein expression and cardiac remodeling in heart failure.

This study identifies ZNF704 as a driver of breast carcinogenesis by disrupting circadian rhythms through repression of PER2 and other clock genes.

The paper uses single-cell RNA-seq data to identify subclonal compositions in TNBC and links them to survival outcomes and immune microenvironment diversity.

The paper identifies CsHscB from Clonorchis sinensis as a TLR2 agonist that modulates macrophage activation and IL-10 production through TLR2-dependent mechanisms.

This study investigates whether intravenous ICG can label immune cells in the human retina and finds it is insufficient for robust labeling in blood or retina.

The paper identifies diverse putative e-pilin genes from environmental metagenomes using updated aromatic density thresholds, expanding known e-pili diversity in metal-rich ecosystems.