J. Wu

The paper investigates off-target mutations caused by prime editors and finds no observable gRNA-independent off-target effects in transfected human cells.

This paper develops a mini-replicon-based reverse-genetics system for RSV, enabling functional analysis of its genes and host interactions in Nicotiana benthamiana.

This study identifies 12 serum metabolites associated with esophageal squamous cell carcinoma and highlights pipecolic acid as a predictive biomarker for tumorigenesis.

The study compares antibody responses in asymptomatic and symptomatic SARS-CoV-2感染者, finding that symptomatic individuals maintain higher and longer-lasting IgG and neutralizing capacities.

The paper examines TF loss patterns in mammals and links them to macroevolutionary events and life history traits.

The paper investigates how RNA-binding proteins (RBPs) influence RNA polymerase II activity through phase separation, showing that RBPs like PSPC1 enhance polymerase engagement and transcription.

This study shows that EGCG from green tea inhibits SARS-CoV-2 and its variants by blocking spike protein binding to ACE2 receptors.

An off-the-shelf bioadhesive patch is introduced for facile sutureless repair of gastrointestinal defects, addressing various limitations of conventional suture-based treatments.

This paper presents a hardware-software solution for co-registering photoacoustic tomography and MRI images in vivo, demonstrating hybrid-contrast imaging of tumor microenvironments.

This study evaluates S-Trimer, a subunit vaccine candidate for COVID-19, showing it induces protective immunity in nonhuman primates with adjuvants.

This study uses single-cell RNA sequencing to identify cell type-specific molecular changes and altered intercellular communications in COPD, linking them to alveolar epithelial dysfunction.

This study identifies FAM114A1 as a regulator of cardiac fibrosis by modulating Ang II signaling in cardiac fibroblasts, showing its role in fibrosis and potential as a therapeutic target.

This study identifies OsNLP3 as a key regulator of nitrogen use efficiency and grain yield in rice under nitrate-sufficient conditions.

This study identifies AGL16 as a negative regulator that suppresses stress response genes to balance growth and stress tolerance in plants.

The paper identifies immune hubs in colorectal cancer by analyzing transcriptional and spatial patterns in MMRd and MMRp tumors.

This study develops process-based tree phenology models for subtropical trees using experimental data, showing advanced spring phenology under warming with species-specific responses.

This study shows that honeybee genetics influence gut microbiota composition and strain-level diversity through social transmission, revealing a gut-brain connection.

This study shows Ox-LDL, not AngII, induces LOX-1 and AT1-R interaction, leading to cardiomyocyte hypertrophy via Gq protein activation.

This paper develops a barnacle-inspired hemostatic paste that rapidly seals tissues by repelling blood with a hydrophobic matrix and crosslinking with tissues under pressure.

This paper introduces a computational method for optical sectioning using phase-space imaging with an incoherent multiscale scattering model, achieving improved signal-to-background ratio in biological samples.

The paper identifies a peroxidase inhibitor, 6D1, that enhances kanamycin activity against carbapenem-resistant bacteria.

Momilactone B inhibits Arabidopsis growth and development by disrupting ABA and auxin signaling, highlighting the role of phytohormones in allelopathic responses.

The paper identifies species-specific genetic differences in ACE2 that determine SARS-CoV-2 entry capability and shows that humanizing these residues in koala and mouse ACE2 enables viral entry.

The paper finds that long-term molecular evolutionary rates, not mutation rates, determine intraspecific genetic diversity across mammals, and shows that epithelial cell evolution drives morphological changes.

BacAnt is a webserver that simultaneously annotates antibiotic resistance genes, integrons, and transposable elements in bacterial DNA sequences, generating automated genbank files.

This study shows that altering energy metabolism via IDH gene knockdown affects foraging behavior in termites, with social context modulating these effects.

The paper identifies public antibody clones in the human repertoire, including virus-neutralizing and anti-PD1 clones, and introduces a tool for analyzing Rep-seq data.

The paper reports the cryo-EM structure of human NALCN with FAM155A, revealing interactions and ion-binding sites that inform Na+ permeation and disease mechanisms.

The paper analyzes metabolic diversity in mononuclear phagocytes across tissues using integrated datasets and a network-based approach, identifying key metabolic subnetworks and their functional roles.