J. Yu

This study shows that PAMc recognition and cleavage in one Cas1-Cas2 site allosterically regulate non-PAMc association in the other site, mediated by Cas2 and DNA.

This study identifies impaired microbial detoxification in autistic children using a quasi-paired cohort strategy, linking it to mitochondrial damage and potential therapeutic strategies.

This study uses TRACE-seq to analyze single throat swabs, integrating SARS-CoV-2 genome, microbiome, antibiotic resistance, and host response data.

This study reports cryo-EM structures of potent SARS-CoV-2 neutralizing antibodies, revealing bivalent binding mechanisms and their correlation with enhanced neutralization and S1 subunit shedding.

This study develops VLP-based vaccines targeting the HIV-1 FP8 epitope, showing they induce high-titer FP8-specific antibodies and effective neutralizing responses in mice.

This study finds that patients with severe SARS-CoV-2 disease have higher antibody titers against viral proteins and neutralization capabilities compared to less severe cases.

The paper determines cryo-EM structures of bat and pangolin coronavirus spikes, showing PCoV_GX spike binds human ACE2 like SARS-CoV-2, while RaTG13 does not, and identifies key residues and glycans involved in RBD function.

This study corrects a disease-causing mutation in a mouse model of tyrosinemia type 1 using ex vivo base and prime editing with chemically derived hepatic progenitors, improving survival rates.

This study identifies miR-424(322) as a molecular switch that controls the differentiation of pro-inflammatory monocyte-derived DCs (moDCs) versus anti-inflammatory Langerhans cells (LCs) by modulating TGF-β signaling.

The paper analyzes mutation spectra and compositional variability in SARS-CoV-2 clades to understand mutation patterns and their implications for viral proteomes.

The paper identifies carboxylesterases and lysosome-related organelles as essential for modular metabolite assembly in C. elegans, including ascarosides and glucosides.

This study uses PepSeq to map SARS-CoV-2 antibody epitopes and identifies cross-reactivity with hCoV-OC43.

The paper isolates and characterizes 61 SARS-CoV-2-neutralizing monoclonal antibodies from infected patients, identifying potent antibodies targeting multiple epitopes on the spike protein.

This study identifies Na2CO3-responsive proteins and phosphoproteins in alkaligrass, revealing mechanisms for photosynthesis and ROS homeostasis under alkali-salinity stress.

This study develops a biomaterial vaccine using mesoporous silica rods to deliver SARS-CoV-2 antigens and adjuvants, showing rapid antibody responses and neutralizing activity.

This study shows that nicotinamide mononucleotide (NMN) treatment reduces the beneficial effects of exercise on glucose handling in diet-induced obese mice, likely due to altered redox metabolism.

This paper develops an inducible mouse model of childhood HIV-associated nephropathy (HIVAN) and shows HIV-Tat contributes to the disease when combined with other HIV-1 genes and heparin-binding cytokines.

The paper shows that IMD/Relish suppresses perilipin1, leading to lipid droplet enlargement that reduces ROS stress during bacterial infection in Drosophila.

The paper identifies an immunosuppression signature (IMS) and shows that its ratio to an IFN-γ signature better predicts anti-PD-1 therapy response in melanoma than existing biomarkers.

This study shows Carmofur inhibits SARS-CoV-2 main protease by covalently binding to Cys145 and occupying the S2 subsite, with an EC50 of 24.30 M in cell-based viral replication assays.

The paper shows that inhibiting the integrin-TGF-β axis enhances NK cell function against glioblastoma stem cells, suggesting it as a therapeutic target.

This paper proposes a two-stage deep learning method for ECG denoising using U-net and DR-net models, showing improved performance over single-stage methods.

This study identifies RNF43 mutations that predict sensitivity to Wnt inhibitors by analyzing their functional impact in vitro and in vivo.

The paper provides three resources to improve DSF experiments: an interactive theoretical framework, practical tips, and online data analysis tools, available at DSFworld.

This study isolates and characterizes 206 RBD-specific monoclonal antibodies from SARS-CoV-2 infected individuals, finding diverse neutralizing activity and species-specific antibody responses.

This paper uses autofluorescence imaging to study macrophage metabolism and behavior in 3D tumor models, revealing metabolic heterogeneity and migration patterns.

The paper identifies a mechanism-based inhibitor of the COVID-19 virus main protease through structure-assisted drug design and high-throughput screening.

The paper reports cryo-EM structures of HKU2 and SADS-CoV spike glycoproteins, revealing structural similarities and evolutionary insights into coronavirus evolution.

The paper determines the crystal structure of the 2019-nCoV spike RBD bound to ACE2, revealing structural similarities to SARS-CoV and insights into antibody epitopes.

The paper introduces a method to determine the source of coprolites and paleofeces using microbiome composition and host DNA content, distinguishing between human, canine, and non-fecal materials.