J. Zhao

This paper determines the cryo-EM structure of Favipiravir bound to SARS-CoV-2 polymerase, revealing its base-pairing mechanism and implications for antiviral drug development.

This study compares the therapeutic effects of Remdesivir and Au22Glutathione18 in COVID-19 golden hamsters, finding that the gold compound better suppresses viral replication and inflammation.

This study uses iTRAQ proteomics to identify 20E and PLC inhibitor-regulated proteins in Apolygus lucorum, revealing shared and distinct DEPs and their involvement in metabolic and signaling pathways.

This study reports cryo-EM structures of potent SARS-CoV-2 neutralizing antibodies, revealing bivalent binding mechanisms and their correlation with enhanced neutralization and S1 subunit shedding.

This paper develops a computational model of ant-colony house-hunting behavior, showing how social information influences consensus and decision-making.

This paper develops a LAMP assay for rapid detection of the nirS gene in denitrifying bacteria, showing high specificity and sensitivity compared to conventional PCR.

The paper identifies proximal tubule cell state and metabolism as coupled by nuclear receptors in kidney disease using single-cell RNA-sequencing.

This study shows EZH2 inhibitors inhibit CRPC growth by downregulating DNA repair genes, making cancer cells more sensitive to genotoxic stress.

This paper demonstrates that engineered T cell libraries with CAR constructs can recognize nonself-antigens, expand clonally, persist, and show immunologic memory against tumors in murine models.

This paper develops membrane nanoparticles from ACE2-rich cells that effectively block SARS-CoV-2 infection by trapping the viral S1 protein and inhibiting its interaction with host cells.

This study shows that MGMT genomic rearrangements cause TMZ resistance in gliomas and can be detected in exosomes as potential recurrence markers.

The paper develops a microfluidic digital immunoassay using machine learning for rapid, multiplexed biomarker detection in clinical samples.

This study genetically modifies human macrophages with CARs to target SARS-CoV-2, showing that CARMERTK macrophages reduce viral load without increasing proinflammatory cytokines.

This paper introduces an FNC-based GAN for classifying mental disorders from fMRI data, achieving higher accuracy than existing methods in MDD and schizophrenia classification.

The paper constructs an AI-RIL population and generates a de novo genome assembly for B. rapa to study natural variation and improve genetic mapping resolution.

The paper localizes Fusarium hyphal growth in FHB-infected grains during malting and links it to mycotoxin production using microscopy and metagenomics.

The paper identifies EB1 as an interacting partner of PTPN22 and shows that this interaction regulates T cell receptor signaling by modulating EB1 phosphorylation and downstream signaling molecules.

This study investigates the ATPase activity of BfpD, a type IV pilus extension ATPase in EPEC, revealing contamination issues and functional differences between BfpD and BfpF mutants.

This study shows that S-enantiomers of chloroquine and hydroxychloroquine are more effective against SARS-CoV-2 and less toxic than their R-enantiomers, suggesting S-HCQ as a better treatment option for COVID-19.

This study shows that skin scarification delivery of MVA vectors generates robust T cell immunity against respiratory viral challenges, outperforming other routes and suggesting its potential for vaccines like COVID-19.

This study shows that transient hyperglycemia causes long-term vascular endothelial dysfunction and delayed wound healing through DNMT1-mediated Ang-1/NF-κB pathway activation.

The paper determines the near-atomic structure of the SARS-CoV-2 polymerase complex and shows reduced activity and thermostability compared to SARS-CoV.

The paper identifies a genomic instability gene signature linked to poor survival in esophageal adenocarcinoma and validates its role in tumor growth and genomic instability.

This study identifies and characterizes ZmCPAs in maize, showing their roles in salt tolerance through expression analysis and functional validation.

The paper optimizes the RNAscope RNA-ISH method for plant tissues, enabling spatial gene expression visualization in barley and Arabidopsis.

The paper investigates how lectin-like intestinal defensin HD5 inhibits 2019-nCoV Spike protein binding to ACE2, showing a high-affinity interaction and protective effect in vitro.

The paper compares silicone and cotton swabs for RNA extraction in COVID-19 testing, finding silicone swabs yield higher RNA concentration and quality.

This study isolates and characterizes 206 RBD-specific monoclonal antibodies from SARS-CoV-2 infected individuals, finding diverse neutralizing activity and species-specific antibody responses.

This paper demonstrates the feasibility of using microelectrophoresis to deliver nanoparticles into living cells, showing successful ejection of quantum dots into human kidney cells with minimal damage.

This study examines cross-reactive antibody responses between SARS-CoV-2 and SARS-CoV, finding common binding but rare neutralization, suggesting non-neutralizing antibodies target conserved epitopes.