J. Zhao

The paper develops CM93, a novel EGFR inhibitor with improved targeting and brain penetration, showing better efficacy and safety in mouse models of EGFR-mutant NSCLC and brain metastases.

This study compares transcriptional responses to oncogenes in cancer-resistant and -prone species, finding that naked mole rat cells resist Ras-induced changes due to dampened PI3K/AKT signaling.

This study identifies a non-canonical histone acetyltransferase in CYC/TB1-like proteins that regulates plant architecture by modifying histone H3 and activating gene expression.

This paper introduces a novel tissue biopsy culture method that improves fungal detection compared to traditional methods.

The paper identifies endoimmune cells, a novel subpopulation of endothelial cells in zebrafish, using single-cell RNA sequencing and shows their involvement in immune responses.

The paper identifies RNA G-quadruplex structures in Arabidopsis and rice, showing they regulate translation and plant growth.

This study identifies sex pheromone plasmids as a mechanism for disseminating linezolid-resistance in E. faecalis through plasmid transfer.

This study shows anlotinib inhibits drug-resistant colorectal cancer cell proliferation and induces apoptosis by inactivating the PI3K/AKT pathway.

This study shows GLUL promotes lung cancer cell growth under glutamine sufficiency through enzyme-independent upregulation of CaMK2G.

This paper introduces amino and PEG-amino functionalized graphene oxide grids to improve sample concentration, distribution, and protection for cryo-EM.

The paper introduces a method to predict the functionality of low-frequency missense mutations by integrating mutation counts with relative mutational difficulty, revealing functional p53 mutations and potential cancer prevention strategies.

This study identifies YAP1 as a context-specific driver for the squamous subtype of pancreatic ductal adenocarcinoma and shows WNT5A promotes tumor progression through YAP1 activation.

This study determines the structure of the DCAF15-DDB1-DDA1-Indisulam-RBM39 complex, revealing how Indisulam promotes RBM39 degradation via a novel degron motif.

This study shows that absence of geomagnetic field reduces feeding in brown planthopper nymphs, leading to lower body weight and altered glucose levels and appetite-related gene expression.

This study shows that CD8+ T-cells mediate immunoediting in murine gliomas, affecting genomic stability and immune evasion.

The paper develops a model showing that protein-DNA bonds can become catch bonds through facilitated dissociation, where competitor proteins enhance dissociation but forces suppress it by inhibiting competitor binding.

This study shows that SCFAs from gut microbiota stimulate GLP-1 secretion in chickens, which suppresses hepatic lipogenesis.

This study compares bird-related cultural ecosystem services across three stakeholder groups in northwestern Costa Rica using surveys and finds differences in perceived values and correlations with affect heuristics.

The paper examines the relationship between ecological stoichiometry and plant community diversity in arid ecosystems of the Tarim River, finding significant correlations between nutrient content and diversity indices.

This study shows TP, activated by Twist1, promotes HCC metastasis and VM via pentose Warburg effect by linking pentose phosphate pathway and glycolysis.

This study investigates how peiminine induces apoptosis in HepG2 cells through both extrinsic and intrinsic pathways, showing dose- and time-dependent effects.

The study examines EGFR exon19 mutation subtypes in non-small cell lung adenocarcinoma and finds that CSS mutations are associated with shorter progression-free survival compared to CD/CSS+SNV mutations.

This paper identifies disulfiram and Bay 11-7082 as pyroptosis inhibitors that covalently modify a conserved cysteine in gasdermin D, thereby blocking pore formation and inflammation.

The paper investigates phylogenetic relationships among Avena taxa using the Pgk1 gene, revealing structural divergence and evolutionary relationships between genomes.

This study uses single-cell RNA sequencing to analyze transcriptomic changes in pancreatic cancer precursors, revealing epithelial and microenvironmental heterogeneity during progression to cancer.

This study shows PIP5K1β regulates bone homeostasis by modulating osteoclast and osteoblast differentiation through multiple signaling pathways.

This paper develops a novel MDS patient-derived xenotransplantation model in MISTRG mice that faithfully represents all MDS subtypes and enables effective drug testing.