J. Zhao

This study reports a pan-drug-resistant Klebsiella pneumoniae isolate carrying NDM-5 and MCR-8.2 genes, along with chromosomal resistance mechanisms to colistin and tigecycline.

This paper shows that SARS-CoV-2 triggers mast cell degranulation, leading to alveolar epithelial inflammation and lung injury, and that MC stabilizers can reduce these effects.

This study identifies WDR5 as a reader of H3Q5ser, showing it binds to this modification and promotes transcription in neuroblastoma cells, suggesting a role in tumorigenesis.

The paper identifies telocytes as regulators of macrophage activity in periodontitis through HGF/c-Met signaling, showing they shift macrophages to an M1/M2 hybrid state.

This study shows that deleting HIF2 in cancer-associated fibroblasts reduces pancreatic tumor growth and immunosuppression, suggesting HIF2 as a therapeutic target.

This study shows a single-dose AAV-based vaccine induces long-lasting neutralizing antibodies against multiple SARS-CoV-2 variants in rhesus macaques.

This study develops an IFN-armed RBD dimer vaccine that induces strong neutralizing antibodies and T cell responses, offering complete protection against SARS-CoV-2 in rhesus macaques with a single dose.

The paper identifies a Nup358 helix that transitions to an α-helix upon BicD2 binding, facilitating dynein recruitment and processive motility.

This study investigates how high temperatures affect meiosis in autotetraploid Arabidopsis thaliana, revealing that heat stress disrupts chromosome axis stability and meiotic recombination.

This study characterizes the in vivo RNA structurome of Plasmodium falciparum, revealing structural features that influence translation and decay, and comparing it to a balanced species.

This study investigates associations between ABO and RhD blood groups and a wide range of diseases using a large population dataset, identifying 49 and 1 significant associations after adjustment.

This study analyzes rabies virus variants from ferret badgers in China, identifying four lineages and assessing their pathogenicity and distribution.

This study examines how acute isolation affects vocal and non-vocal social behaviors in male and female mice during same-sex and opposite-sex interactions, finding stronger effects in females.

This study evaluates glycoproteomics software performance using human serum datasets, identifies high-performance strategies, and provides recommendations for improved analysis.

The paper explores polyyne biosynthetic gene clusters in bacteria, identifies a conserved seven-gene cassette in Pseudomonas, and discovers the metabolite protegencin.

This study identifies CTPS1 as a target for antiviral therapy by showing it suppresses interferon induction and promotes viral replication in SARS-CoV-2 infection.

This study identifies and characterizes six AcMNPV-encoded miRNAs, showing they regulate both viral and host genes through suppression or enhancement of target expression.

This study shows that GS-441524, a metabolite of remdesivir, effectively inhibits SARS-CoV-2 in cell cultures and mice, suggesting it may contribute to remdesivir's antiviral activity.

This study evaluates how SARS-CoV-2 variants bind animal ACE2 proteins and their sensitivity to neutralizing antibodies and ACE2-Ig constructs, finding increased ACE2 affinity and partial resistance to antibodies but enhanced neutralization by ACE2-Ig.

The paper shows that bacterial DNA recombination increases tRNA levels early in antibiotic stress, aiding resistance before efflux pumps or mutations.

This study identifies the ZmCd1 gene controlling cadmium accumulation in maize grains and develops molecular markers for breeding low-Cd maize varieties.

This study evaluates SARS-CoV-2 entry mediated by ACE2 from 11 species, finding that pangolin and some mammals allow entry, while others do not, suggesting complex cross-species transmission potential.

This study develops and tests a recombinant RBD-Fc vaccine against SARS-CoV-2, showing protection in non-human primates and mice.

This paper demonstrates the first use of high-energy X-rays in FLASH radiotherapy, showing effective tumor control and tissue protection in mice.

This paper develops a 3D adaptive optical nanoscopy technique that achieves sub-50 nm resolution in thick specimens by addressing optical aberrations.

The paper identifies a CD127-expressing monocyte subset, M127, associated with anti-inflammatory properties in inflammatory diseases and correlates its expansion with milder COVID-19 outcomes.

This study shows that sucrose promotes tillering in rice by inhibiting strigolactone (SL) signaling, specifically by suppressing D3 and D14, which are key components of SL perception and D53 degradation.

This study assesses bacterial abundance and diversity in 70-year-old desiccated soils, showing significant resuscitation potential and activity of certain taxa after rewetting.

This study identifies genetic determinants of COVID-19 drug efficacy using genome-wide CRISPR screens, revealing genes involved in drug metabolism and immunosuppressive effects.

This study shows that TIGIT-Fc promotes antitumour immunity by enhancing CD8+ T and NK cell effector functions and inducing Th1 development, suggesting its potential as a therapeutic strategy.