L. Feng

Natural naphthoquinones isolated from Lithospermum erythrorhizon suppress dextran sulfate sodium-induced murine experimental colitis

This study shows that shikonin and its derivatives reduce inflammation in DSS-induced colitis by inhibiting NLRP3 inflammasome and NF-κB pathways.

In situ Fucosylation for Modulating Wnt Signaling in Live Cells

This study shows that fucosylation of N-glycans modulates Wnt signaling by affecting LRP6 endocytosis, revealing a new glycosylation-dependent regulatory mechanism.

TMEM16F phospholipid scramblase mediates trophoblast fusion and placental development

This study identifies TMEM16F as a phospholipid scramblase essential for trophoblast fusion and placental development by externalizing phosphatidylserine.

MicroRNA-378 suppressed osteogenesis of mesenchymal stem cells and impaired bone formation via inactivating Wnt/β-catenin signaling

Analytical treatment interruption after short-term anti-retroviral therapy in a postnatally SHIV infected infant rhesus macaque model

This paper develops an infant rhesus macaque model of SHIV infection and analytical treatment interruption to study viral rebound and identify biomarkers for pediatric HIV functional cure strategies.

The conserved metalloprotease invadolysin is present in invertebrate haemolymph and vertebrate blood

This study identifies invadolysin, a conserved metalloprotease present in invertebrate hemolymph and vertebrate blood, suggesting a role in organismal physiology.

Conserved Roles of C. elegans and Human MANFs in Sulfatide Binding and Cytoprotection

This study identifies C. elegans MANF orthologue, shows it binds sulfatide, and demonstrates sulfatide-dependent cytoprotection in both worms and mammalian cells.