L. Jin

This study shows Brsk2 amplifies parasympathetic signals to promote type 2 diabetes by enhancing β-cell insulin secretion in obese mice and associates human BRSK2 variants with metabolic disorders.

This study shows that (R)-NNAL promotes lung cancer progression by deactivating LKB1 through β-AR signaling, while (S)-NNAL has weaker effects.

The paper profiles single-cell transcriptomes of decidual macrophages in normal and recurrent spontaneous abortion patients, identifying distinct polarization states and potential therapeutic targets.

This study identifies Sting as a regulator of fatty acid metabolism and shows its cross-talk with PUFAs to modulate inflammatory responses.

This study identifies the lncRNA PLANE as a regulator of alternative splicing that promotes cancer progression by repressing NCOR2-202 splicing, leading to poor patient outcomes.

This study identifies keratin 1-based epidermal green autofluorescence as a biomarker for non-invasive assessment of inflammation and oxidative stress levels in the body.

This study compares nitrogen dynamics in maize-soil systems with urea and urea-straw treatments, finding that straw enhances nitrogen availability through rhizosphere interactions.

This study shows that miRNA-223 inhibits gallstone formation in mice by targeting ABCG5 and ABCG8, key transporters in the bile cholesterol secretion pathway.

This study identifies lung macrophages that kill helminths by depleting arginine through differential activation of recruited monocyte-derived alveolar macrophages.

The paper identifies a suboptimal-health gum state (SoH) during experimental gingivitis, characterized by microbiome and metabolite changes similar to periodontitis.

The paper uses fluorescent glycan uptake and genomic analyses to study strain-level differences in carbohydrate metabolism among rumen bacteria.

This study shows paternal obesity increases breast cancer risk in female offspring and this predisposition can be passed to the next generation through altered sperm tRNA fragments.

The paper shows cyclic di-GMP differentiates lung moDCs into Bcl6+ and Bcl6- subsets, which induce memory TH and TFH cells respectively, enhancing mucosal vaccine responses.

This study examines the relationship between phosphorus digestibility and gut microbiota in goats, finding significant correlations between TDP and specific bacterial taxa in different gastrointestinal regions.

This paper uses deep learning to improve structured illumination microscopy, reducing image requirements and enabling low-light, high-speed super-resolution imaging.

This study creates a zebrafish model expressing Abcb4 to investigate drug resistance mechanisms, finding that NF-κB plays a central role in regulating Abcb4-mediated resistance.

This study shows that DDT exposure in male mice alters sperm RNAs, which transmit cancer susceptibility to female offspring through miRNA-10b, leading to increased tumor aggressiveness.

The paper compares fecal microbial compositions between female osteoporotic patients and healthy controls, identifying bacterial taxa associated with osteoporosis and demonstrating predictive power using a random forest model.

This paper presents a 3D printed microheater integrated microneedle patch system for controlled drug delivery, demonstrating its integration with wearable electronics for pain management.

This study quantifies selective pressures on human pigmentation genes across populations and time periods, finding directional selection on light and dark pigmentation traits.

This study identifies SLC7A5 (LAT1) as a contributor to endocrine resistance in ER+ breast cancer by showing its role in metabolic reprogramming and growth suppression upon inhibition.

This study investigates how procyanidin affects collagen type I assembly using AFM, CD, and DSC, finding that PA induces globular aggregates and inhibits fibrillogenesis, while GA crosslinking stabilizes fibrils but reduces flexibility.

This study develops a coarse-grained model to predict 3D structure, stability, and flexibility of dsRNAs in salt solutions, showing improved accuracy with electrostatic potential inclusion.

This paper identifies the JH/PTTH hormonal cascade as regulating phototaxis switch in Leptinotarsa decemlineata larvae during ontogenetic niche shift.

The paper analyzes the global spread of the mcr-1 gene by sequencing isolates and phylogenetic analysis, finding all mcr-1 elements originated from a single mobilization event in the mid-2000s.