L. Li

This study shows that 4-PBA reprograms monocytes to resolve inflammation and atherosclerosis by altering adhesion and increasing anti-inflammatory markers.

The paper investigates phototoxicity in nonlinear optical imaging and proposes a technique to mitigate it using rapid sub-80-fs excitation with full triplet-relaxation.

This study identifies VCP/p97 as an obligate co-factor of ASPSCR1-TFE3, showing it organizes enhancer loops to drive oncogenic transcription in ASPS and RCC.

This study examines PKM1 and PKM2 expression in mouse and human prostatic tissues across development, benign, and cancerous states, revealing distinct patterns in PCa and NEPCa.

The paper investigates post-photosynthetic fractionation effects on δ13C in a C4 grass, finding that δ13C of cellulose is more reliable for predicting physiological parameters than δ13C of bulk organic matter.

This study shows NSD2 acts as a tumor suppressor in Kras-driven pancreatic cancer by regulating NF-kappa B signaling through multiple mechanisms.

This study reports the cryo-EM structure of the Rho-Rof antitermination complex and shows Rof inhibits Rho-dependent termination, essential for bacterial virulence.

This study identifies acetylation patterns that drive tau fibril formation and shows their structural and functional role in tauopathies.

The paper identifies DNA methylation changes in sepsis-induced monocyte dysregulation and shows these can be reversed with specific treatments.

This study identifies HSPA8-mediated CLPP stability as a regulator of mitochondrial autophagy and cisplatin resistance in ovarian cancer cells.

This study demonstrates nitrate-dependent anaerobic oxidation of ethane and butane by Candidatus Alkanivorans nitratireducens, revealing the fumarate addition pathway's role in SCGA metabolism.

This study shows that CCL5-CCR5 signaling in the prefrontal cortex of female mice contributes to stress susceptibility by altering microglia function and BBB integrity.

This study shows that oxytocin reduces colitis and CAC by enhancing MUC2 fucosylation via OXTR, suggesting it as a potential therapeutic for these conditions.

This study investigates the role of IRF4 and IRF5 in neutrophil response during septic peritonitis, showing their involvement in PMN phenotype switching and inflammatory outcomes.

This paper introduces GSE-Seq, a high-throughput platform for single-entity sequencing that enables long-read profiling of dsDNA and ssDNA from viruses and bacteria, revealing previously overlooked dark matter and phage-host interactions.

This study examines how age and sex influence neuroinflammation after SARS-CoV-2 infection in mice, finding that males and older animals show greater weight loss, viral load, and immune response, while no virus was detected in the brain.

This paper identifies palmitoylation at C64 as critical for preventing unproductive STING oligomerization and shows a peptide inhibitor targeting the oligomerization interface.

This study identifies two novel double-negative prostate cancer subtypes using scRNA-seq and develops a web tool for visualization.

This study shows DEC1 regulates circadian rhythms in β-cells, linking them to metabolic maturation and glucose responsiveness.

The paper identifies chemotherapy-induced TXNIP as a negative regulator of GDF15 in CRC, showing its potential as a prognostic biomarker through organoid models.

This study identifies essential genes and genomic features of Xanthomonas citri using transposon mutagenesis, revealing insights into its genome organization and potential therapeutic targets.

This study identifies hypermutated IGHV3-53/3-66 antibodies from breakthrough infections that broadly neutralize SARS-CoV-2 variants including BQ and XBB.

This paper identifies Acb2 as a phage-encoded protein that sequesters multiple cyclic dinucleotides and trinucleotides, inhibiting CBASS immunity.

This study identifies ENPP1 as an innate immune checkpoint that suppresses the cGAMP-STING pathway, promoting tumor growth and metastasis, and shows that inhibiting its cGAMP hydrolase activity enhances cancer immunity.

This study creates a pH-insensitive NCX1 mouse and finds it has reduced growth, accelerated cardiac repolarization, and is resistant to ischemia/reperfusion injury.

This study shows that apoptosis and pyroptosis clear engineered Salmonella from different organs in mice, with pyroptosis being more effective in myeloid niches and apoptosis in the intestinal niche.

This study identifies PELI2 as a regulator of the STING pathway that suppresses basal IRF3 signaling and enhances NF-κB signaling to modulate anti-viral responses and prevent interferonopathies.

This study examines Listeria species in beach sand, identifying hypervirulent isolates and their potential role in human listeriosis.

This study shows that p38α inhibition reduces immunosuppression by MDSCs and enhances immunotherapy in TNBC by decreasing CXCL1/CXCL2 expression.