L. Li

The paper introduces a modular prime editing system called SunTag-PE that improves delivery efficiency without compromising editing efficiency.

The paper develops a framework to select optimal cell lines for high-content screening based on task and compound library characteristics, improving drug discovery efficiency.

Lon1 knockout inhibits mitochondrial-encoded gene translation and induces retrograde signaling involving unfolded protein responses.

The paper identifies Angptl4's role in shaping intrahepatic T-cell activation via eIF2α signaling during fibrosis in diet-induced NAFLD.

The paper compares the roles of TIR1 and AFB1 in transcriptional and rapid auxin responses, showing their distinct functions are due to specific protein properties, not subcellular localization.

The paper reports the cryoEM structure of the ISW1a complex bound to the dinucleosome, revealing its mechanism of nucleosome spacing and organization.

The paper uses metagenomics to identify 22 RNA viruses in ticks from northeastern China, revealing novel species and highlighting public health risks from emerging tick-borne viruses.

This paper develops cholesterol-deficient T cell membrane-coated nanoparticles to deliver STING agonists for tumor immunotherapy, showing improved blood clearance evasion and enhanced antitumor effects.

The paper determines the structure of a human odorant receptor bound to propionate, revealing how odorant recognition and activation occur through specific molecular interactions.

This study examines how pH changes affect alkaline phosphatase activity in six dinoflagellate species, revealing species-specific responses to ocean acidification.

The paper identifies a mechanism where auxin signaling via ABP1-TMK1 receptor module stabilizes PIN2 to reinforce asymmetric auxin flow for root gravitropism.

This study evaluates multivalent HCMV gB mRNA vaccines in rabbits, finding increased T cell responses but no improvement in antibody breadth.

This study shows that amyloid-beta peptides inhibit glucose transport at the blood-brain barrier by disrupting the insulin-Akt pathway and increasing TXNIP expression.

This study links social stress to autoimmune responses against the brain, showing increased IgG antibodies correlate with depression-like behaviors in mice and humans.

This paper presents a method to estimate thermodynamic and kinetic parameters of protein condensates from finite-sized simulations, showing differences in nucleation behavior between NDDX4 and FUS-LC.

The paper examines how tidal fluctuations and human disturbances affect microbiota structure and assembly in intertidal groundwater-surface water systems, identifying rhythmic microbial patterns and their environmental drivers.

This study develops a computational pipeline combining metagenomics and metaproteomics to identify proteins' metabolic and ecological roles in gut microbiomes using simulated and real data.

This paper identifies a broadly neutralizing antibody against SARS-CoV-2 that targets the receptor-binding site and remains effective against multiple Omicron subvariants.

This study identifies a mitochondrial iron-calcium signaling mechanism in Parkinson's disease and discovers drug targets using Miro1-based screens and genetic analysis.

The paper identifies a proliferative exhausted CD8+ T cell cluster in HPV-positive HNSCC that correlates with better patient survival and suggests potential therapeutic implications.

This study identifies genomic signatures of convergent adaptation to high altitudes in alpine plants by analyzing reference genomes and gene expression profiles.

The paper investigates the correlation between skin and musk glands in Chinese forest musk deer, finding strong gene expression overlap and roles for Sox9, Caveolin1, and AR in both tissues.

This study identifies Bifidobacterium pseudolongum as inducing an early anti-inflammatory response that influences cardiac transplant outcomes.

This study shows IRE-1α regulates both necroptosis and pyroptosis in mice by modulating GSDMD activity, with implications for therapeutic targeting in tissue injuries.

This study investigates brevicidine's antimicrobial mechanism against AMR Gram-negative pathogens and shows its efficacy in a mouse model.

This study identifies GLKs as regulators of carotenoid biosynthesis through GBF-dependent transcriptional activation and phase separation-mediated nuclear condensates.

The paper identifies a novel reversible prenylation on ALDH9A1 lacking a canonical prenylation motif, revealing a new type of protein-lipid modification.

The paper identifies HLY72, a small-molecule derivative of lycorine, as an anti-obesity agent that targets Na+/K+-ATPase α3 in the brain, promoting lipolysis and thermogenesis without affecting food intake.

This study identifies ZmGL8 as a key gene regulating the balance between cuticular wax production and jasmonic acid-mediated defenses in maize, showing its role in modulating plant defense responses.