L. Liu

This paper identifies false-positive peptide inhibitors of KRas using orthogonal assays and cellular screens, highlighting the need for rigorous validation in drug discovery.

This paper identifies and characterizes an NAD-dependent xylitol dehydrogenase from Gluconobacter oxydans WSH-003, showing high activity for D-sorbitol to D-fructose conversion and distinct optimal conditions.

The paper determines the absolute protein stoichiometry of carboxysomes and reveals their organizational variability in response to microenvironmental changes.

This study shows that low concentrations of melatonin promote cotton seed germination by enhancing antioxidant enzyme activity, reducing MDA, and modulating plant hormones like ABA and GA3.

This study identifies TMC1 as providing a background leak conductance in mouse auditory hair cells, essential for action potential firing and tonotopic organization.

This study identifies key gut bacteria correlated with systemic iron levels using a murine model and bioinformatic tools, establishing a non-invasive prediction model for iron-related diseases.

The paper identifies intronic heterochromatin as a mechanism suppressing cryptic transcription initiation by TEs in Arabidopsis.

This study shows that G3BP domains are required for alphavirus replication complex clustering and translation initiation, with SFV and CHIKV relying on different G3BP domains for replication.

This study evaluates bio-bitumen made from biomass pyrolysis oil as a substitute for petro-bitumen in coating sheets, showing improved adhesion, temperature stability, mechanical strength, and flexibility.

This paper introduces a heterogeneous loop model to infer 3D chromosome structures from Hi-C data and validates it against experimental measurements.

This study introduces SLHC-seq, a new targeted sequencing method that improves detection of pancreatic cancer by analyzing short mutant cfDNA fragments, enabling earlier diagnosis.

This study investigates the selectivity of 4-aminoquinolines for the alpha2A-adrenoceptor using docking, molecular dynamics, and mutagenesis to identify binding sites and affinity determinants.

This study shows that pre-infection modulation of host glycolysis with 2-DG enhances resistance to M. marinum infection by reducing phagocytosis and bacterial proliferation.

This paper identifies niclosamide and nitazoxanide as potent TMEM16A antagonists that fully bronchodilate airways, offering new treatment options for severe asthma and COPD.

This study shows that TLR3 deficiency worsens epithelial barrier loss in genital tract Chlamydia muridarum infection, as measured by transepithelial resistance and tight-junction gene expression.

This paper introduces ICO-seq, a method to profile gene expression in large numbers of yeast colonies, and applies it to study gene expression heterogeneity in engineered yeast strains.

This study identifies Lsm12 as a regulator that mediates Polη deubiquitination to enhance its recruitment and improve survival under oxidative stress in yeast.

The paper analyzes anti-V2 antibody levels in HIV-1 infected individuals and finds that some show deficiency, which correlates with viral V2 region characteristics.

The paper identifies two Daple/CCDC88C isoforms, showing they cooperatively suppress tumor growth but only the full-length isoform triggers EMT and invasion, with aspirin affecting their expression.

The paper develops a biochemical assay to screen for PHGDH inhibitors, identifies piperazine-1-thiourea compounds, and evaluates their biological impact on serine metabolism in cancer cells.

The paper shows that miR1510 in Phaseoleae species is primarily a 22 nt isoform due to monouridylation, and demonstrates how post-processing modifications can optimize miRNA function.

The paper models human interphase chromosomes as a self-avoiding polymer to study their glassy dynamics and shows agreement between simulations and experimental data.

This study shows that knocking down GAS5 restores ox-LDL-induced autophagy dysfunction in endothelial cells by upregulating miR-26a.

The paper uses scRNA-seq to identify a profibrotic macrophage subtype in injured lung tissue, showing its role in fibrosis and potential as a therapeutic target.

This study assesses the acute and chronic toxicity of benzylpenicillin G residues in heat-treated animal food products using a mouse model, finding reduced LD50 and organ damage at high exposure levels.

The paper introduces a method combining aptamer probes and transcriptome sequencing to simultaneously analyze transcriptomes and proteomes of single cells, enabling cell type differentiation based on binding and expression patterns.

The paper uses a heteropolymer model with Hi-C data to study chromatin dynamics, finding that chromosome architecture determines spatiotemporal behavior and cell-to-cell variability.

This study uses SLIM to measure sperm cell thickness and refractive index, finding tail thickness down to 150 nm and refractive index up to 1.6 near the head.

The paper identifies 22 ancient whole genome duplications in Malpighiales, clustered around the Eocene-Paleocene Transition, supporting the hypothesis that WGDs aid plant survival during climatic upheavals.

The paper shows that FEA2, a CLAVATA receptor, responds to two different CLE peptides by signaling through distinct downstream effectors CT2 and CRN.