L. Liu

This study analyzes SARS-CoV-2 genome data to infer its evolution and population demography using phylogenetic and population genetics methods.

The paper uses cryo-EM to reveal the post-fusion structure of SARS-CoV-2, showing the S protein in a state with S1 disassociated.

This paper develops a transferable and interpretable deep learning model for MSI prediction from histopathology images, achieving high AUC scores in two cohorts.

The paper investigates the genetic basis of rumen evolution by comparing transcriptomes and genomic data across ruminants, camels, and cetaceans, identifying key genetic innovations.

This study identifies adaptive divergence followed by population admixture as a source of additive genetic variance in evolutionarily important traits, showing a strong positive correlation between heritability and evolutionary importance.

This study identifies acetylation as essential for NLRP3 inflammasome activation, showing that KAT5-mediated acetylation promotes NLRP3 aggregation and inflammasome assembly.

This study shows NDRG2 maintains intestinal epithelial barriers by regulating E-cadherin and adherens junctions, preventing colitis and tumor development.

This study shows that acetyl-CoA from specific metabolic pathways enhances cardiac repair after myocardial infarction by promoting histone acetylation and antioxidant gene expression.

This paper characterizes an ammonia-tolerant ammonia-oxidizing archaeon from vegetable soil, identifying genomic and physiological mechanisms underlying its high ammonia tolerance.

This study shows cells can sense long-range biomechanical forces through the matrix to initiate distant mechanical communication, enabling coordinated self-assembly.

This study compares substitution, concatenation, and multispecies coalescent models across 47 phylogenomic datasets, finding the coalescent model performs better.

The paper examines insulin signal transduction in the retina of db/db mice, finding impaired signaling marked by increased TNF and IRS-1 phosphorylation and reduced Akt phosphorylation.

This study identifies qKW9, a gene affecting maize kernel weight by regulating photosynthesis through C-to-U editing of NdhB.

This study demonstrates that transient expression of Runx1 and Hoxa9 in pluripotent stem cells generates functional T cells capable of immune surveillance and tumor eradication.

This study identifies lncRNA AVAN as a positive regulator of antiviral innate immunity by interacting with TRIM25 and enhancing FOXO3a transcription.

A CGMMV-based vector enables gene function studies in cucurbits, an extremely low efficiency species for genetic transformation.

This study identifies mutations that enhance chitinase activity on oligomeric substrates but not crystalline chitin, highlighting the importance of using physiologically relevant substrates in enzyme engineering.

This study shows that the maize Gβ subunit controls both shoot meristem development and immune responses, with implications for optimizing growth and defense tradeoffs in crops.

This study investigates changes in mechanical properties and nanomorphology of BMSCs during early apoptosis using AFM and other techniques, finding that mechanical damage precedes apoptotic signals.

This paper shows overexpression of ELO2 in yeast increases complex sphingolipids, improving osmotic tolerance and cell survival under high salt conditions.

This study compares the shapes and sizes of prostate lesions in dogs treated with laser, radiofrequency, and microwave ablation, finding significant differences in lesion morphology and volume.

This study shows that effector T cells use inosine as an alternative carbon source under glucose restriction, enhancing anti-tumor function and bypassing tumor-imposed metabolic limitations.

This paper introduces a high-throughput platform that links optical and gene expression profiling of single cells, demonstrating accurate measurements from thousands of cells and characterizing DNA and RNA changes in Jurkat cells through the cell cycle.

This paper introduces a multi-dimensional separation method for glycosaminoglycan oligosaccharides that enables structural and functional analysis without desalting.

This paper demonstrates an enzyme-free method to synthesize natural phospholipids in water, forming cell-like membranes and establishing proton gradients.

The paper develops a droplet-digital Cas13a assay for single-molecule microRNA quantification, demonstrating its precision, specificity, and broad applicability.

This study investigates how terminal tagging affects the oligomerization of the sigma 1 receptor using a modified Western blot protocol, revealing that the N-terminus influences ligand binding effects while the C-terminus is more suitable for modifications.

The paper identifies dysbiosis in RA tonsillar microbiota and shows that Streptococcus salivarius and its antibacterial peptides modulate autoimmunity by suppressing T cells and autoantibodies.