L. Liu

This study compares the functional properties of the B.1.1.529 SARS-CoV-2 spike glycoprotein with previous variants, finding reduced processing and lower stability but equivalent infection efficiency and increased ACE2 binding affinity.

The paper reports a cryo-EM structure of the SARS-CoV-2 Omicron spike protein, revealing how mutations alter its conformation and enable antibody resistance.

This study shows that the Omicron variant of SARS-CoV-2 is highly resistant to neutralization by convalescent serum and vaccines, and many monoclonal antibodies.

This study uses high-temporal-resolution transcriptome profiling to compare interferon responses after mRNA vaccination and SARS-CoV-2 infection, identifying distinct signatures linked to immune outcomes.

The paper identifies a human monoclonal antibody that neutralizes all tested sarbecoviruses and describes a new antibody class with potential for pandemic preparedness.

The paper uses mass spectrometry to determine the absolute stoichiometry of native and recombinant carboxysomes, revealing structural variability and assembly principles.

This study develops an organoid-based method to generate large quantities of NK cells from human pluripotent stem cells without feeder cells, achieving efficient and scalable iNK cell production.

This study evaluates off-target mutations caused by high-activity adenine base editors in rice, finding that TadA9 variants and CRISPR/SpCas9n-NG increase off-target A>G SNVs, with RNA mutations clustering more than DNA mutations.

A third dose of inactivated SARS-CoV-2 vaccine significantly enhances plasma neutralization and generates high-affinity anti-RBD memory B cells against variants like Beta, Delta, and Lambda.

This study develops engineered small extracellular vesicles targeting FGL1 and PD-L1 to suppress immune rejection in transplantation by inhibiting T cell activation and improving graft survival.

This study shows that humanized mice can be infected by SARS-CoV-2, leading to immune responses and immunopathology, providing a model for studying the virus and testing therapies.

This paper derives analytic expressions to predict multi-way chromatin contacts from Hi-C data, showing good correlation with experimental measurements.

ReCOV, a trimeric SARS-CoV-2 subunit vaccine, induced neutralizing antibodies and complete protection against SARS-CoV-2 in mice and rhesus macaques.

This study uses phylogeographic analysis of Mesobuthus mongolicus to show its lineage diverged from Central Asia 1.36 Ma and used the Junggar Basin as a corridor for faunal exchange between Central and East Asia.

This study shows that Hoxb5 can convert multipotent blood progenitors into hematopoietic stem cell-like cells with long-term repopulating ability.

This study shows that intranasal influenza-based boost vaccination enhances mucosal and systemic immunity against SARS-CoV-2, effectively preventing infection in both upper and lower respiratory systems.

This study uses spatial transcriptomics to analyze invasive fronts in solid tumors, identifying immune cell enrichment, metabolic changes, and poor prognosis factors.

This study introduces scStereo-seq, a method for single-cell spatial transcriptome profiling in Arabidopsis leaves, revealing cell type-specific spatial gene expression gradients and developmental trajectories.

The paper introduces a method to sense enzyme product formation using host cell metabolism and mass spectrometry to map enzyme activity and mutagenesis effects.

This paper identifies a monoclonal antibody, 2-36, that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses, with a conserved epitope in the RBD identified through cryo-EM.

This study shows that dimeric IgA antibodies can enhance SARS-CoV-2 nasal infection and injury in Syrian hamsters by engaging CD209 as an alternative receptor.

The paper identifies 2-isobutylmalate synthase (IBMS) as a novel enzyme related to IPMS that catalyzes the synthesis of 4-methylvaleric acid, a precursor of pogostone.

This study investigates how Schistosoma mansoni eggs interact biomechanically with vascular endothelial cells to facilitate their extravasation from blood vessels.

This study evaluates a vaccinia-based COVID-19 vaccine, showing it induces strong and long-lasting cellular and humoral immune responses in mice against SARS-CoV-2 variants.

This paper demonstrates that intranasal nanobody Nb22 provides short-term instantaneous prophylaxis and effective treatment against SARS-CoV-2 in hACE2 mice, with ultrahigh potency and long-lasting retention in the respiratory system.

This study uses genome-wide analysis to track polyploid emergence in Phragmites australis, identifying multiple lineages and ploidy levels with genomic conflicts.

This study shows that homoharringtonine (HHT) effectively inhibits KIT-dependent GIST growth by reducing protein synthesis, even in imatinib-resistant models.

The paper constructs a global microbiome transition network showing microbiomes are closely connected despite habitat differences, with a scale-free structure and a roadmap of dispersal.

This study identifies OPAQUE1 as essential for phragmoplast guidance during asymmetric cell division in maize, showing it interacts with kinesins to ensure proper cytokinesis.