M. Li

This study shows that a recombinant SARS-CoV-2 S1-Fc fusion protein induces strong neutralizing antibodies in nonhuman primates and can be produced at scale for vaccine development.

This paper creates a single-cell transcriptomic atlas of the Chinese horseshoe bat to study its role as a viral reservoir, identifying cell types and receptor expression patterns related to viral entry.

The paper screens FDA-approved drugs against SARS-CoV-2 in different cell types, identifying three FDA-approved antivirals with potential for clinical use.

This study shows that loss of Aldob activates Akt, promoting hepatocellular carcinoma by destabilizing the Aldob/Akt/PP2A complex, and identifies SMAP as a potential therapeutic agent.

This paper develops CNN models to automatically classify Nugent scores from vaginal microscopy images, achieving higher accuracy than human experts.

This study shows that Asgard archaea possess ESCRT complexes with eukaryotic-like structural and functional features, suggesting they are evolutionary precursors to eukaryotic ESCRTs.

This paper investigates the ligand recognition mechanism of PHF20L1 Tudor1, revealing a pre-existing open conformation that enables binding to both methylated proteins and small molecules.

The paper shows that inactivating the TN/TX microRNA-degrading enzyme in mice causes adiposity similar to Tsn deletion, but cell-specific deletion does not replicate this effect.

This study shows that social stress in SIV-infected macaques increases viral load and T cell activation during acute infection compared to socially housed animals.

The paper identifies two novel BRAF gene fusions in pediatric histiocytic neoplasms and shows they respond differently to RAF inhibitor therapies due to distinct dimerization mechanisms.

This study identifies IRF8 as a key factor in tumor-associated macrophages (TAMs) that induce T cell exhaustion by presenting cancer antigens, and shows its association with poor patient survival in renal cell carcinoma.

This study shows that blocking TGFβ signaling in CD4+ T cells enhances type 2 immunity, promoting tumor healing and halting cancer progression through IL-4-mediated vasculature repair.

This study compares the effects of different fertilization patterns on soil microbial diversity, structure, and function in greenhouse vegetable production systems, finding that higher manure substitution improves soil quality and microbial activity.

The paper investigates the genetic basis of rumen evolution by comparing transcriptomes and genomic data across ruminants, camels, and cetaceans, identifying key genetic innovations.

This paper identifies a dual activity in LanD-like flavoproteins for forming aminovinyl-cysteine residues through oxidative decarboxylation and cyclization of peptides.

This study finds that KALRN mutations enhance anti-tumor immunity and immunotherapy response in cancer by increasing tumor mutation burden and PD-L1 expression.

The paper introduces a deep learning method to predict virus hosts using DNA sequences, applied to 2019-nCoV to identify potential hosts like bats and minks.

The paper investigates arsenite's effects on IL-1beta secretion, mitochondrial respiration, and myocardial ischemia-reperfusion injury in rats.

The paper identifies two distinct mechanisms by which small molecules inhibit LpxA acyltransferase, a key enzyme in lipopolysaccharide biosynthesis.

This study identifies two small-molecule inhibitors of LpxA, revealing distinct inhibition mechanisms and highlighting compound 2's improved properties for antibacterial development.

The paper presents a low-cost setup for fluctuating light experiments and improves throughput of the IMAGING-PAM for plant phenotyping.

This study identifies a new Asgard archaeal phylum, Gerdarchaeota, and shows their role in organic matter degradation in coastal sediments through genomic and transcriptomic analysis.

The paper shows that TORC1 inactivation leads to vacuole membrane remodeling via ubiquitination and ESCRT-dependent microautophagy.

This study reports the crystal structure of the N-terminal domain of DdMCU and shows its oligomeric state and calcium-dependent dissociation.

This study identifies Msi1+ cells as rapidly cycling intestinal stem cells that regenerate the intestine independently of Lgr5high cells.

This study optimizes fertigation for greenhouse strawberries by identifying the optimal levels of N, P, K, and water to maximize yield and SSC/TA ratio.

The paper analyzes NLR resistance genes in wild tomato species, revealing their evolutionary dynamics and structural diversity using SMRT sequencing.

The study evaluates bacterial contamination of computer equipment in a hospital, finding mouse pads are highly contaminated and require daily cleaning.

This paper uses zero-inflated models to predict future Zika outbreak suitability based on climate data and finds most regions will become more suitable under extreme climate change scenarios.