M. Liu

This study shows that ex vivo delivery of regulatory T cells to donor lungs before transplantation can suppress alloimmune responses and improve lung graft outcomes in a rat model.

This study identifies the mechanism of bacterial galactosemia, showing that galactose interferes with MurG, an essential glycosyltransferase, leading to cell wall biosynthesis inhibition and cell death.

The paper introduces a microchip called NOMA that enables sequential tracking of secretions from the same single cells with high retention efficiency.

This study shows that adiponectin improves healthspan and lifespan by enhancing insulin sensitivity and reducing age-related metabolic and inflammatory disorders in mice.

This study identifies abundant and diverse circRNAs from SARS-CoV-2, SARS-CoV, and MERS-CoV, revealing a novel type of circRNA distinct from DNA-encoded circRNAs.

The paper quantifies the phase separation properties of chromatin-associated proteins using an anti-1,6-hexanediol index and shows functional correlations with chromatin organization.

This study identifies PCSK9 as a target to enhance CD8+ T cell antitumor activity by modulating LDLR and TCR signaling in the tumor microenvironment.

This paper introduces a bioprinting method that controls cellular orientation through stretching, enabling aligned myofiber formation and effective tissue repair in vivo.

The paper examines how plot diversity affects the metabolome of leaves, roots, and root exudates in four subtropical tree species, finding stronger effects on leaves than roots or exudates.

This study identifies genetic determinants of COVID-19 drug efficacy using genome-wide CRISPR screens, revealing genes involved in drug metabolism and immunosuppressive effects.

This study identifies Cx43's role in glioblastoma chemoresistance by activating PI3K signaling, and shows that targeting Cx43 and PI3K{beta} restores temozolomide sensitivity.

This study shows that AdCOVID, an intranasal vaccine, induces both systemic and mucosal immunity against SARS-CoV-2 in mice.

The paper identifies a cyclin A-specific interaction between SKP2 and CDK2-cyclin A complexes that promotes p27KIP1 degradation, distinguishing cyclin A from other G1 cyclins.

This paper introduces a probabilistic and anisotropic failure metric to improve risk stratification for ascending thoracic aortic aneurysm by incorporating patient-specific biomechanical data and uncertainty in wall strength.

This study shows telmisartan enhances insulin secretion via ion channels, independent of AT1 receptor and PPARγ, in rat islets and diabetic mice.

This study shows TIN2 promotes TRF1-mediated DNA-DNA bridging on telomeres, stabilizing interactions that depend on telomere length and sequence.

This study shows JQ-1 reduces liver fibrosis in Schistosoma-infected mice by inhibiting JAK2/STAT3 signaling in hepatic stellate cells.

This study shows Rbx1 and Ube2m differentially regulate Treg cell homeostasis and function, with Rbx1 deletion causing severe inflammation and Ube2m deletion causing milder issues, suggesting therapeutic potential for targeting neddylation/CRLs in immune disorders.

The paper identifies four dominant mutations, three significant multi-site co-mutations, and a 5'UTR CpG escape mutation that drive the rapid evolution of SARS-CoV-2.

The paper identifies GRL0617 as a non-covalent inhibitor of SARS-CoV-2 PLpro with an IC50 of 2.1 μM, supported by co-crystal and NMR data showing its mechanism of action.

This study shows that SETD2 deficiency disrupts the β-catenin destruction complex, promoting ccRCC formation, and links SETD2-mediated H3K36me3 to Wnt/β-catenin signaling in renal cancer.

This paper presents a chromosome-level genome assembly and annotation of Magnolia biondii, revealing insights into its evolutionary history and gene function.

The paper determines the structure of SARS-CoV-2 Mpro and shows how GC376 inhibits its catalytic site, supporting its use as an antiviral drug.

The paper identifies TGFBI as a protein promoting NF-kappa-B mediated angiogenesis during early lung development by enhancing nitric oxide production.

This study uses single-cell transcriptomics to reveal diverse immune cell roles in the developing mouse lung, showing dynamic changes in macrophage subtypes and their functions during lung development.

This study constructs a pangenome of Claviceps purpurea and identifies factors like a large accessory genome, high recombination rates, and positive selection on secondary metabolite genes that contribute to its global distribution and broad host range.

The paper identifies two SNPs in SARS-CoV-2 genomes prevalent in North America, traces their origin to Europe, and suggests they could be targets for surveillance and treatment.

This study infects hACE2 transgenic mice with SARS-CoV-2 and observes pathogenic effects, confirming Koch's postulates and establishing a model for vaccine and therapeutic development.

This study models how interspecific competition narrows thermal performance curves and shows that intraspecific cooperation can counteract this effect in beetles.