N. Chen

The African swine fever virus protease pS273R inhibits DNA sensing cGAS-STING pathway by targeting IKKε

This study identifies pS273R as an ASFV protease that inhibits the cGAS-STING pathway by targeting IKKε, revealing a new immune evasion mechanism.

RORγt serine 182 tightly regulates T cell heterogeneity to maintain mucosal homeostasis and restrict tissue inflammation

This study shows that RORγt serine 182 regulates T cell heterogeneity in the intestine, maintaining homeostasis and limiting inflammation.

ADAR2 deaminase activity promotes Th17 effector function and protects against intestine inflammation

This study shows ADAR2 promotes Th17 effector function by editing Malt1, leading to increased IL-17A and protection against intestinal inflammation.

Targeting Allostery in the Dynein Motor Domain with Small Molecule Inhibitors

This study develops small molecule inhibitors targeting allostery in dynein motor domains by inhibiting regulatory ATPase sites rather than the main catalytic site.

WOX9 functions antagonistic to STF and LAM1 to regulate leaf blade expansion in Medicago truncatula and Nicotiana sylvestris

The paper shows WOX9 negatively regulates leaf blade outgrowth in Medicago truncatula and Nicotiana sylvestris by antagonizing STF and LAM1, with STF repressing WOX9 activity to maintain proper blade development.

Sequence-based Prediction of Metamorphic Behavior in Proteins

This paper introduces a sequence-based computational model to predict metamorphic behavior in proteins using diversity indices derived from secondary structure predictions, achieving a Matthews correlation coefficient of ~0.4.

Microbial redox activity mediated anaerobic pyrite oxidation under circumneutral conditions

This study investigates microbial mediation of anaerobic pyrite oxidation under circumneutral conditions and identifies ligand production as a preferred pathway over acidic micro-environments.

Effective Combination Immunotherapy using Oncolytic Viruses to Deliver CAR Targets to Solid Tumors

This study combines oncolytic viruses with CAR T cells to deliver CD19 antigen to solid tumors, enhancing CAR T cell anti-tumor responses.

Control of cytokinesis by β-adrenergic receptors indicates an approach for regulating cardiomyocyte endowment

This study shows that β-adrenergic receptor signaling regulates cardiomyocyte cytokinesis, and β-blockers like propranolol can enhance division in ToF/PS cardiomyocytes, potentially improving heart function in CHD patients.

Allele frequency dynamics in a pedigreed natural population

This study uses pedigree and genomic data from Florida Scrub-Jays to analyze how genetic drift, selection, and gene flow influence allele frequency changes over time.

Deconstructing isolation-by-distance: the genomic consequences of limited dispersal

The paper investigates how limited dispersal in Florida Scrub-Jays shapes fine-scale genetic structure, showing stronger isolation-by-distance in males due to sex-specific dispersal patterns.