N. Zhang

This study shows that the disordered N-terminal region of SETD2 regulates its proteasome-mediated decay, affecting H3K36me3 deposition and transcriptional fidelity.

The paper identifies EB1 as an interacting partner of PTPN22 and shows that this interaction regulates T cell receptor signaling by modulating EB1 phosphorylation and downstream signaling molecules.

This study identifies two bacterial lipases with broad-spectrum antiviral activity against multiple enveloped viruses, including SARS-CoV-2, by disrupting viral envelopes.

The paper introduces 2D-HELS-AA MS Seq to directly sequence tRNA, revealing different isoforms and dynamic base modifications.

This paper develops a novel mouse model for SARS-CoV-2 infection and evaluates the protective efficacy of an RBD-based subunit vaccine.

The paper identifies metabolic subtypes of colorectal cancer using metabolomics and finds correlations between these subtypes and clinical outcomes.

This study profiles the 2-hydroxyisobutyrylome in common wheat, identifying Khib modification sites and their roles in metabolic pathways and enzyme regulation.

This study shows SlWak1 promotes apoplastic immune responses to Pseudomonas syringae in a Fls2- and Fls3-dependent manner, acting in a complex with these receptors during PTI.

This study characterizes non-neutralizing gB-specific monoclonal antibodies from HCMV-infected individuals, revealing their binding specificity, genotype preference, and effector functions like ADCP and ADCC.

This study identifies acetylation as essential for NLRP3 inflammasome activation, showing that KAT5-mediated acetylation promotes NLRP3 aggregation and inflammasome assembly.

This study characterizes CRISPR/Cas9-induced mutations in 63 immunity-associated genes in tomato, revealing mutation types, heritability, and specificity.

The paper shows that different quorum sensing signals (AHLs) induce prophages in soil bacteria, altering community structure by targeting specific taxa.

This study identifies signature microbiota linked to rumen function shifts in goat kids due to solid diet supplementation using machine learning and functional analysis.

This study evaluates the methodological quality of animal studies using the SYRCLEs risk of bias tool, finding significant differences between Chinese and English studies.

This study introduces a method using a single FT expression cassette in CRISPR/Cas9 to rapidly generate and identify transgene-free mutants in Arabidopsis.

This paper introduces a new LC/MS-based RNA sequencing method that directly analyzes multiple-base modifications in RNA mixtures, enabling accurate sequencing and quantification of both canonical and noncanonical bases.

This study examines how century-long fertilization affects microbial community succession and assembly mechanisms in grassland soils.

This study identifies SKI-73 as a CARM1 chemical probe that reduces breast cancer cell invasion by altering epigenetic plasticity, distinct from CARM1 knockout effects.

This study analyzes genome-wide divergence patterns in two incipient shorebird species with gene flow, finding distinct genomic regions associated with reproductive isolation and adaptation.

This study identifies mutations in dynein's stalk that disrupt directional motion and reveal the role of the stalk in coupling conformational changes across the AAA ring.

This study identifies KMT2D as a tumor suppressor in melanoma, showing its loss leads to metabolic reprogramming toward glycolysis and dependence on IGF signaling, suggesting therapeutic targeting of these pathways.

This study shows that spotted doves can be infected with SFTSV, with severity depending on viral strain and dose, and suggests they may play a role in virus transmission.

The paper identifies 63 nuclear protein-coding loci markers that are effective for avian phylogenetic and population genetic studies, showing comparable polymorphism to mitochondrial loci.

The paper identifies a novel TOR-regulated pathway involving STL1 that enhances Cryptococcus virulence in low-nutrient conditions.

This paper reviews the role of retrosplenial cortex in spatial cognition, classifying proposed functions into three categories and suggesting ways to test them.