N. Zhang

This study shows that Bacillus velezensis SQR9 uses a type VII secretion system to acquire iron from plant roots, enhancing its colonization.

The paper identifies TGF-β-dependent differentiation of stem-like CD8+ T cells into tissue-resident memory T cells in tumor draining lymph nodes, which negatively correlates with tumor vaccine response.

This study identifies LENG8 as an mRNA processing factor that regulates mitochondrial activity by controlling mRNA nuclear export and mitochondrial protein expression.

This study shows ARID1A loss activates HERVH, which promotes tumor growth by modulating BRD4-dependent transcription in colorectal cancer.

This paper develops a refillable PMMA bone cement composite for localized, multi-window chemotherapy of bone cancer, showing sustained drug release and improved cytotoxicity compared to conventional methods.

This study develops dual-payload antibody-drug conjugates to overcome breast tumor heterogeneity and drug resistance, showing improved efficacy in a xenograft model.

This paper develops a machine learning model using Raman spectroscopy to accurately identify viruses, achieving high accuracy in classifying virus types and subtypes.

This study reveals the structural basis of SETD2 methyltransferase interaction with hnRNP L paralogs, showing how a leucine pair in SETD2 interacts with hnRNP L RRM2 and affects splicing regulation.

This study shows that cavefish enhance lipogenesis via upregulated Pparγ to store more fat, aiding adaptation to nutrient scarcity.

This study identifies Chi3l1 as a key mediator of acetaminophen-induced liver injury by promoting hepatic platelet recruitment through the CD44 axis.

This study determines the cryo-EM structure of HCMV Pentamer bound to neuropilin 2 and neutralizing antibodies, revealing molecular interactions and epitopes involved in viral tropism and neutralization.

This study examines how high light and high temperature affect photosynthesis in Setaria viridis, revealing distinct mechanisms and acclimation strategies in C4 plants.

This study shows O-GlcNAc modification of MTA1 enhances its chromatin binding and transcriptional activity, aiding breast cancer cells in adapting to genotoxic stress.

This study determines the structure of the p75NTR-DD/TRADD-DD complex and shows TRADD recruitment regulates NF-κB signaling and cell survival in cerebellar granule neurons.

This study uses deep learning to predict cell sizes from laser mode imaging of single-cell lasers, demonstrating sub-wavelength accuracy in both synthetic and biological cell models.

The paper describes a new fungal genus and species from root-associated environments, proposes a new family based on phylogenetic and phenotypic data, and highlights limitations of sequence-only analyses.

This study characterizes the dynamic changes in B-cell receptor repertoires of COVID-19 patients using next-generation sequencing, revealing clonotype overlap, lineage expansion, and V gene usage patterns.

This study uses three-color single-molecule imaging to track dynein's conformational dynamics during motility, revealing variable stepping between domains and a large number of conformational states.

This study shows that human ILC2 cells can be activated by TLR4 signaling through LPS, leading to cytokine production and B cell activation, distinct from classical IL-33 activation.

This study identifies a viral protein translation mechanism involving mitochondrial machinery and highlights mitochondria as a target for antiviral drug development.

The paper investigates cross-reactivity between mugwort and house dust mite allergens, finding that mugwort tropomyosin induces a non-Th2 response in allergic rhinitis patients.

This paper shows anti-asprosin monoclonal antibodies reduce appetite, body weight, and blood glucose in metabolic syndrome mouse models.

The study examines how different low-temperature conditions affect microbial communities in an Anearobic-Anoxic-Oxic wastewater treatment process on the plateau, finding temperature impacts on specific bacterial abundances.

This paper identifies SPP1+ macrophages and fibroblasts in liver metastatic CRC TME that form immunosuppressive networks, promoting tumor growth and poor prognosis.

The paper identifies lysine isobutyrylation as a new histone modification mark and shows its role in epigenetic regulation and cellular physiology.

This study develops a cell-based chimeric vaccine against SARS-CoV-2 that induces strong T cell immunity and neutralizing antibodies without toxicity.

This study maps QTL for leaf angle in maize using an F3:4 RIL population and identifies 24 candidate genes in two QTL regions.

This study examines genetic sources of variation and variability in Drosophila grooming behavior, finding that genetic differences lead to distinct phenotypes but not increased individual variability.

This study shows PKD1 phosphorylates CBX8, disrupting PRC1 complex binding and promoting cell senescence by derepressing p16.