R. Yang

This study examines the distribution of transcriptional outputs in Myc-amplified medulloblastoma cells and identifies IMPDHs as a therapeutic target.

This study identifies upregulated and downregulated kinases in KRAS-mutant pancreatic cancer using chemical proteomics, revealing potential therapeutic targets.

The paper synthesizes genomic, historical, and ecological data to argue that Yersinia pestis entered Europe multiple times during the Second Plague Pandemic, supporting repeated introductions from Asia.

The paper identifies PD-L1-lncRNA, a long non-coding RNA splice variant of PD-L1, that promotes lung adenocarcinoma progression by enhancing c-Myc activity.

This study shows that CRTC-CREB activation drives LKB1-null lung cancer growth and identifies it as a therapeutic target.

The paper introduces the Allen Cell and Structure Segmenter, an open-source toolkit for 3D segmentation of intracellular structures in fluorescence microscopy images, achieving high accuracy through classic and deep learning workflows.

The paper determines high-resolution structures of outer-arm dynein arrays bound to microtubule doublets, revealing a mechanism for motor coordination through ATP hydrolysis and tail-to-head interactions.

This study compares the early host responses to SARS-CoV-2, SARS-CoV, and MERS-CoV infections using transcriptome analysis, revealing distinct patterns of cytokine and antiviral gene expression.

This study identifies cooperating mutations that drive leukemia in mice with B cell transcription factor defects and suggests PDK1 inhibitors as potential therapies.

The paper develops an EGCG-modified EDC/NHS collagen membrane to enhance macrophage adhesion and vascularization, showing improved cell viability and potential for implant dentistry.

This paper develops a robust neutralization assay using SARS-CoV-2 S-bearing VSV pseudovirus and ACE2-overexpressed BHK21 cells to screen antibodies and quantify neutralizing titers.

This study identifies T-bet deficiency as a cause of mycobacterial disease by impairing IFN-γ production in innate and innate-like adaptive lymphocytes.

This study investigates how different surface topographies of biomaterial scaffolds affect skin wound healing in mice, finding that aligned scaffolds enhance regeneration and modulate immune responses.

This study investigates ion and water permeation mechanisms of the SARS-CoV-2 E protein channel using in silico methods, revealing hydrophobic gates and voltage-dependent behavior.

This study predicts lncRNA-encoded small peptides in glioma and analyzes their oligomer channel function using in silico methods.

This study shows that transient hyperglycemia causes long-term vascular endothelial dysfunction and delayed wound healing through DNMT1-mediated Ang-1/NF-κB pathway activation.

This study identifies stem cell-like GBM cells outside the contrast-enhancing region and proliferative lymphocytes in GBM patients' blood, linking them to recurrence and immunotherapy.

The paper investigates correlated evolution of large DNA fragments in the 3D genome of Arabidopsis thaliana, showing that spatially interacting fragments exhibit similar polymorphism and evolutionary rates.

The paper identifies coadapted genetic elements in Vibrio parahaemolyticus through genome-wide screening, revealing complex interactions and ecological strategies.

The paper identifies dysbiosis in RA tonsillar microbiota and shows that Streptococcus salivarius and its antibacterial peptides modulate autoimmunity by suppressing T cells and autoantibodies.

The paper shows that ASCL1-regulated DARPP-32 and t-DARPP promote SCLC growth and survival through Akt/Erk signaling and anti-apoptotic pathways, with t-DARPP overexpression linked to Notch signaling activation in SCLC patients.

The paper identifies RET kinase as a targetable driver in neuroendocrine prostate cancer (NEPC) through phosphoproteomics and pharmacological inhibition studies, showing reduced tumor growth in models.

The paper estimates recombination scaled effective population size in 21 bacterial species and finds only two show signs of panmixia, suggesting panmixia is unstable in bacteria.

The paper analyzes genomic data from 1,103 Vibrio parahaemolyticus isolates to show recent genetic mixing among four populations due to increased human-mediated dispersal.

The paper defines the core essential genome of Pseudomonas aeruginosa by analyzing multiple strains and growth conditions using Tn-Seq and a novel statistical model, identifying 321 core essential genes.

QuBiT quantifies cell geometry and organization in Drosophila tracheal tubes, revealing new A-P gradients and periodic cell patterns during morphogenesis.

The paper describes a CRISPR/Cas9 method to tag transcriptionally silent genes in hiPSCs with mEGFP, enabling visualization of sarcomeric proteins in live cardiomyocytes.

The paper shows MTAP loss in GBM correlates with an immunosuppressive profile by increasing M2 macrophages and that MTA, a byproduct of MTAP loss, promotes this effect through the A2B receptor.

This study compares the microbiomes of sinus mucus and lung sputum from CF patients, finding distinct community structures and functional profiles between upper and lower airways.

The paper describes a CRISPR/Cas9 method to tag endogenous proteins in human iPSCs, generating 10 tagged lines with quality-controlled clones for cell biology research.