S. Gao

This paper introduces SNU-seq, a method for single-nucleotide uracil mapping in DNA, validated on synthetic DNA and mammalian genomes, revealing uracil dynamics in treated cells and AID hotspots.

This study identifies unbalanced dietary patterns as contributors to precocious puberty by altering gut microbiota and host metabolites, with biomarkers showing high diagnostic accuracy.

The paper identifies the M-Lip domain as a novel dimeric protein fold that binds membranes and is essential for lipin function.

This paper introduces a deep learning method to improve light-field microscopy, enabling high-speed, artifact-free volumetric imaging of biological processes.

This paper develops a chip-based system combining microfluidics and light-field microscopy with deep learning to high-speed 4D image and analyze moving C. elegans.

This study shows Ythdc1, an m6A reader, regulates LINE1 scaffold function in mouse ESCs, affecting self-renewal and differentiation through chromatin interactions.

This study systematically analyzes peroxiredoxins (PRDXs) across 33 cancer types, examining expression, genetic alterations, methylation, prognosis, pathways, and drug targets, with validation of PRDX6's role in bladder cancer cell proliferation via JAK2-STAT3 pathway.

This study shows EZH2 inhibitors inhibit CRPC growth by downregulating DNA repair genes, making cancer cells more sensitive to genotoxic stress.

The paper identifies HLA Class I-presented peptides in melanoma and EGFR mutant lung adenocarcinoma using proteogenomic analysis, revealing neopeptides and post-translationally modified peptides for potential immunotherapy.

This study identifies an IL1β/NFκB/ESE3 signaling axis in pancreatic stellate cells that drives fibrosis, chemoresistance, and poor prognosis in pancreatic cancer.

The paper analyzes proteome and phosphoproteome changes in EGFR TKI-resistant lung cancer cells to identify drug targets that can overcome resistance.

This paper uses expansion microscopy to visualize mitochondrial cristae morphology and localize proteins within the intermembrane space using a MtCK-GFP marker.

The paper presents cryo-EM structures of NaChBac in nanodiscs and its complex with HuwenToxin IV, revealing toxin docking details and enabling studies of GMTs on Nav channels.

The paper reports the structure of the ForT/PRPP complex and identifies residues critical for catalysis, proposing a mechanism for C-C bond formation in C-nucleotide antibiotic biosynthesis.

This study presents the structure of primate ferroportin and elucidates its mechanism of iron transport and regulation by hepcidin.

The paper presents the cryo-EM structure of human ACAT1 and reveals its catalytic mechanism and substrate preference for unsaturated acyl chains.

This study evaluates moxifloxacin efficacy against Mycobacterium abscessus in a zebrafish model, finding limited in vivo activity despite good in vitro results.

This study identifies Msi1+ cells as rapidly cycling intestinal stem cells that regenerate the intestine independently of Lgr5high cells.

This study shows that 15-LOX-1 metabolism of LA in PI3P reduces LRP5 membrane levels, inhibits Wnt/β-catenin signaling, and suppresses colorectal tumorigenesis in mice.

This study examines how shift-work affects carotid artery health and cerebral blood flow in SHR and WKY rats, finding increased blood pressure, arterial thickening, and reduced blood flow.

The paper compares subgenome asymmetry in artificial and natural allopolyploid genotypes, finding that variable genome components influence subgenome differences and suggest their consideration in polyploid evolution studies.

This study identifies multiple noncanonical PAMs recognized by SpCas9 in human cells, improving understanding of off-target mutation risks.

This study develops a practical cryopreservation method for human ADSCs without a programmable freezer or serum, showing viability over 18 months at -150°C with specific cryoprotectants.

This study identifies and validates a novel QTL on chromosome 6HL in barley that confers resistance to Fusarium crown rot, explaining 29.1% of phenotypic variance.

The paper reports the cryo-EM structure of tetrameric Ptch1 bound to ShhNp, revealing an asymmetric mechanism of Hh ligand inhibition.

The paper uses quantitative mass spectrometry to analyze proteomic and phosphoproteomic changes in metastatic lung adenocarcinoma and validates a novel somatic mutation CDK12-G879V associated with chemotherapy sensitivity.

This paper uses a convolutional variational autoencoder to cluster protein folding simulations and identify conformational substates, achieving 89% contact prediction accuracy.

This study identifies 916 differentially expressed genes in rat cells over-expressing U1 snRNA, with 12 enriched pathways linked to cancer.