S. Park

This study identifies Nas2's role in regulating the final step of proteasomal ATPase assembly through steric hindrance and an assembly checkpoint.

This study identifies how IL-7 drives the expansion and effector function of prenatal PLZF+ CD4+ T cells in humans, influencing their tissue distribution and differentiation.

This study optimizes a safety switch for CAR T cells by enhancing EGFRt expression, leading to more effective antibody-mediated elimination.

This study examines flight-related morphological scaling in stick insects, showing how wing shape, mass, and muscle distribution change with wing size and flight capability.

This paper presents an experimental microfluidic model to simulate herd immunity for a human coronavirus by varying cell proportions and observing transmission dynamics.

The paper shows elevated arginine levels in liver tumors drive metabolic reprogramming and tumor growth through feedback loops involving ASNS and arginase 1.

The paper investigates how the Chd1 chromatin remodeler is affected by DNA duplex integrity, finding that it is sensitive to poly(dA:dT) tracts and DNA mismatches.

The paper describes a novel oral inhibitor, JSF-2659, effective against multidrug-resistant Neisseria gonorrhoeae and other high-threat pathogens, with low potential for resistance development.

The paper presents a high-resolution structure of the S1P5 receptor complexed with an inverse agonist, revealing structural features that explain receptor subtype selectivity and inverse agonism.

This paper introduces a new sample delivery method for serial femtosecond crystallography, enabling reliable crystal deposition and successful structure determination of lysozyme.

This study combines auxin-producing bacterial culture supernatant with organic and inorganic fertilizers to enhance red kohlrabi growth, showing improved photosynthetic efficiency and photoprotective mechanisms.

This study investigates how glycocalyx thickness, influenced by mucin properties, affects NK cell-mediated cytotoxicity and suggests strategies to enhance cancer immunotherapy.

This study shows that Magnaporthe oryzae uses clathrin-mediated endocytosis to internalize effector proteins into rice cells.

The paper introduces a method to produce graphene-coated grids for cryo-EM and demonstrates their use in determining the structure of sMMOH at high resolution.

The paper identifies a pan-cancer splicing factor module regulated by MYC, showing its role in splicing changes and tumor progression across multiple cancer types.

This paper develops a label-free adaptive optics method for SMLM, enabling deep-tissue super-resolution imaging in whole animals by correcting tissue aberrations.

This study uses whole genome sequencing of Hodgkin and Reed Sternberg cells to reconstruct the temporal evolution of classic Hodgkin lymphoma, identifying key mutations and structural variants.

This study identifies clonal hematopoiesis as an independent risk factor for severe COVID-19 in previously healthy patients, revealing distinct immunological and epigenetic signatures.

This study investigates how genome divergence and compatibility contribute to the stabilization of hybrid genomes in an allopolyploid plant species.

This study develops a multi-domain peptide hydrogel for controlled delivery of Oxo-M and 4-PPBP to enhance tendon regeneration in vivo.

The paper investigates the energy-dissipative state of the major antenna complex in plants under qH conditions and proposes chlorophyll-chlorophyll excitonic interactions as the mechanism.

The paper extends CHARMM-GUI Membrane Builder to model and simulate lipid nanoparticles with ionizable cationic lipids and PEGylated lipids, showing how PEG-lipids affect membrane structure and dynamics.

This paper isolates and characterizes nanobodies from camelids and engineered mice that neutralize SARS-CoV-2 variants through conserved epitopes and multimeric avidity.

This study examines how organic electron donors and terminal electron acceptors shape microbial communities in a stratified lake, showing their roles in community structure and interactions.

This paper develops RSPO4 mutant-based peptibody drug conjugates that target LGR4/5/6, showing potent cytotoxic effects and tumor suppression in vitro and in vivo.

The paper uses synthetic TAL effectors delivered by bacteria to activate the maize gene gl3, revealing its role in cuticular wax biosynthesis and identifying downstream genes involved in this process.

The paper tracks immune cells in live mice to show they maintain a tiling pattern with epithelial cells during homeostasis, regulated by epithelial density and Rac1.

This study identifies sAB-K29, a tool to detect K29-linked polyubiquitin, and shows its role in proteotoxic stress response and cell cycle regulation.

The paper investigates how protein-protein interactions in LHCII affect its optical properties and energy dissipation mechanisms in photosynthesis.

This study uses an E. coli model system to investigate the structure and function of Y. pestis Ail in a bacterial cell envelope, revealing its role in virulence and interactions with human serum components.