S. Park

The paper reveals conserved interaction rules between RNA helicases and TRIM E3 ligases in vertebrate innate immunity using cryo-EM and biochemistry.

This study investigates how cell geometry affects growth, chromosome segregation, and division in Bacillus subtilis L-forms, showing that surface area over volume and nucleoid positioning are key factors.

This study shows that obesity increases organ size, which correlates with higher cancer risk due to more cells at risk of becoming cancerous.

This paper develops a synthetic DNA-based vaccine platform to rapidly generate SARS-CoV-2 vaccines using recombinant MVA vectors expressing spike and nucleocapsid antigens, showing robust immune responses in mice.

This paper identifies a temperature-sensitive fer-ts mutant of FERONIA that affects root hair growth and hormone responses, with altered protein turnover and ROS accumulation at elevated temperatures.

This paper introduces a metagenomic approach to study host-specificity of Lactobacillus reuteri without genome isolation, showing consistent results with prior findings and novel associations in dogs.

This study identifies CCM1 as a regulator of YAP/TAZ signaling that promotes prostate cancer metastasis and is inversely correlated with patient survival.

This study uses a deep learning model to predict antiviral drugs that may target the novel coronavirus 2019-nCoV, identifying atazanavir as the most potent inhibitor.

This study screens 48 FDA-approved drugs for antiviral efficacy against SARS-CoV-2 and identifies 24 drugs with IC50 values between 0.1 M and 10 M, including niclosamide and ciclesonide.

This study shows that Aire's CARD-mediated multimerization forms nuclear foci and affects transcriptional activity, but also increases susceptibility to PML body interactions, which can impair its function.

This study uses live-cell imaging to show Hfq dynamically interacts with mRNAs and sRNAs, recruiting RNase E to promote mRNA turnover and enabling sRNA-mediated gene regulation.

This paper introduces a viscous medium-based sample holder for fixed-target serial femtosecond crystallography, enabling stable crystal support for various sizes and shapes.

The paper benchmarks predictive models for kinase inhibitor potencies using crowdsourced data and identifies new compound-kinase interactions.

The paper measures the microtubule binding kinetics of membrane-bound kinesin-1 motors and finds that motor reattachment is not limited by diffusion but by intrinsic binding rates, predicting high motor copy numbers for long-range vesicle transport.

The paper identifies TOX as a factor promoting T-cell exhaustion and predicts its role in anti-PD1 therapy outcomes using single-cell transcriptome data from cancer patients.

This study examines flight morphology variation in stick insects, finding that intermediate wing sizes are rare and that wing and body size are inversely correlated.

The paper shows that the RNF43-G659Vfs41 mutation is functional and not a driver mutation in tumorigenesis, but may be a passenger mutation in MLH1-downregulated tumors.

The paper investigates freezing tolerance differences between Swedish and Italian Arabidopsis thaliana ecotypes by analyzing CBF2 LOF mutations and their gene expression effects.

This study shows maternal obesity causes ER stress in offspring hypothalamus, leading to metabolic issues and altered neural development, which can be mitigated by tauroursodeoxycholic acid.

This study identifies splicing factors involved in breast cancer initiation and metastasis, showing their differential roles and interactions with MYC.

This paper shows that TDP-43 is more toxic in yeast under respiratory conditions but remains toxic without respiration, suggesting reactive oxygen species may enhance its toxicity.

RIPLET functions as a molecular glue to assemble signaling scaffolds for the antiviral innate immune receptor RIG-I.

This study shows that antigen structure influences DC-SIGN-mediated uptake and trafficking, with larger particulate antigens being routed to HIV-1-associated compartments.

The paper develops an open-source hardware control platform for high-speed device synchronization in optical microscopy, demonstrating its application in various scanning techniques and reducing synchronization artifacts.

This study shows that low-dose cadmium exposure in mice increases lung inflammation and genetic responses to H1N1 influenza virus infection.

This paper improves FRET-PAINT microscopy speed by 8-fold through optimizations in camera speed, probe dissociation, and signal bleed-through, achieving 40-nm resolution in tens of seconds.

The paper reports the crystal structure of the MMOH-MMOD complex, revealing how MMOD inhibits MMOH catalytic activity by competing with MMOB and altering the di-iron centre geometry.

This study compares 6-month angiographic and 2-year clinical outcomes between long and short chronic total occlusion (CTO) lesions after successful DES PCI, finding higher repeat PCI rates in long CTO lesions.

This paper develops a deep learning method using holographic microscopy to rapidly and accurately classify anthrax spores and other pathogens.