S. Wu

This study identifies NMA1982 as a phosphatase in Neisseria meningitidis, showing it uses a PTP-specific catalytic mechanism and is secreted, suggesting it is a virulence factor and potential drug target.

The paper develops a prognostic model using spatially resolved tumor microenvironment features to predict treatment outcomes in relapsed/refractory Hodgkin lymphoma.

The paper identifies transcriptional correlates of ecDNA in tumors, showing upregulation of DNA repair and downregulation of immune pathways.

This study investigates maize COI proteins' roles in growth and defense by analyzing mutants, finding that quadruple mutants show stunted growth, reduced photosynthesis, and DELLA protein accumulation.

This study examines the effects of six pyrimidine analogs on Tetrahymena thermophila growth and their mechanisms of action, finding that different analogs inhibit growth through distinct sites and that some effects are reversible with specific nucleobases or nucleosides.

This paper introduces Alpha-LFM, a physics-aware deep learning framework for 3D super-resolution imaging of living cells, achieving high resolution, speed, and low phototoxicity over long periods.

This study identifies RAY1216, a slow-tight SARS-CoV-2 Mpro inhibitor with improved pharmacokinetics and antiviral activity compared to PF-07321332, currently in phase III clinical trials.

This study combines flexible implantable microelectronics with machine learning to achieve reliable long-term neural decoding for seizure prediction in epileptic mice.

This study identifies BRD9 as a key regulator of pancreatic cancer stem cell stemness and tumorigenesis, showing that its inhibition reduces CSC self-renewal and enhances chemotherapy response.

The paper evaluates phylogenetic models for gene expression evolution using 8 datasets, finding Ornstein-Uhlenbeck models fit 66% of gene-tissue combinations best and highlighting the importance of accounting for evolutionary rate heterogeneity.

This study clarifies the origin of modern maize by showing it resulted from an ancient admixture between domesticated maize and Zea mays ssp. mexicana around 5300 years ago, contributing to genetic and phenotypic diversity.

This study examines the inhibitory effects of dexamethasone on immune cells in Balb/c mice, showing significant reductions in macrophages, DC cells, and monocytes, and suggests GR signaling pathway involvement.

This study shows USP39 promotes liver cancer by regulating alternative splicing through interaction with SRSF6/HNRNPC, identifying it as a potential therapeutic target.

This study reports chromosome-level genome sequences of two Leonurus species, providing resources for studying bioactive molecules in medicinal plants.

The paper identifies an alternative pathway for malonyl-CoA production using oxaloacetate dehydrogenase in Streptomyces, enabling efficient bioproduction of malonyl-CoA-derived chemicals in E. coli.

The paper identifies a proliferative exhausted CD8+ T cell cluster in HPV-positive HNSCC that correlates with better patient survival and suggests potential therapeutic implications.

This study identifies changes in serum protein levels in COVID-19 convalescents compared to healthy controls, revealing both similarities and differences with acute phase changes.

The paper investigates how H3K27me3 marks transposons in different plant lineages and shows that these elements were co-opted as cis-regulatory elements for PRC2-controlled genes during evolution.

The paper identifies a Prunus MAX1 homolog as a strigol synthase that bypasses 5-deoxystrigol synthesis, directly converting carlactone to strigol.

The paper investigates how sub-threshold odor mixtures mask the unpleasant smell of iso-valeric acid using Sniff Olfactometry, finding that mixtures reduce recognition by up to 96%.

This study links SARS-CoV-2 spike-induced syncytia to cellular senescence and exacerbated heart failure, showing that senolytic drugs and WNK1 inhibitors can mitigate cardiac damage.

This study reveals polyphyletic origins of clerodane diterpene biosynthesis in Lamiaceae by analyzing genomes and metabolic pathways of three species.

The paper identifies a SHR-IDD-PIN regulatory network that controls minor vein differentiation in rice and C4 grasses by regulating auxin flow through PIN protein expression.

The paper identifies proteomic signatures associated with seroconversion after flu vaccination in a human cohort, revealing links between protein levels and immune response factors.

This study identifies how pyrin-only-proteins inhibit inflammasomes by targeting different filament assembly steps, revealing their target redundancy and inhibition mechanisms.

The paper identifies a transcriptional signature in primary ccRCC tumors that predicts metastatic potential and patient survival.

This study identifies ANTXR1, heparan sulfate, and Neu5Gc as host factors required for SVV entry into porcine cells using CRISPR screening.

This paper develops a virtual liver needle biopsy method to quantify sampling bias in liver tissue, finding significant intra- and inter-needle variations in collagen proportionate area.

This study identifies AFAP as a bacterial protein that enhances cell adhesion by interacting with host nucleolin, providing insights into the mechanism of A. phagocytophilum-induced cell adhesion in HGA.

The paper identifies energy waves as the mechanism for redistributing heme energy in myoglobin after photolysis, showing they are more efficient than diffusion-based processes.