T. Xu

This study shows oral glucosamine improves neurological symptoms in a mouse model with misfolded HGSNAT due to a Pro304Leu mutation.

This study shows that synergistic enzyme mixtures can achieve near-complete depolymerization of polymer/additive blends by combining random chain scission and processive depolymerization.

This study shows that matrix stiffness affects intestinal stem cell fate by reducing Lgr5high ISCs and promoting differentiation into goblet cells, mediated by YAP nuclear translocation.

Analysis of multiple tmk mutants reveals key roles of TMKs in plant development, including organogenesis, leaf size, fertility, and selfing population defects.

The paper maps receptor expression gradients in macaque cortex, revealing a hierarchy aligned with cortical function and a depression-related gradient in specific regions.

This study develops an OMV-based vaccine using Salmonella Typhimurium to deliver Shigella flexneri 2a O-polysaccharide antigen, showing protection against lethal pulmonary infection in mice.

The paper shows that anatomic position influences oncogenic specificity in melanoma by identifying position-specific gene programs that interact with oncogenes like CRKL.

The paper shows that oncogenic Ras and p53 cooperation activates JAK/STAT non-cell autonomously in the tumor microenvironment, promoting radioresistance and tumor recurrence.

This paper introduces COSI, a label-free imaging method to quantify intra-thrombus mass and adhesive platelet dynamics under fluid shear stress with high precision.

This paper examines how structural geometry, assembly energetics, and cargo release kinetics interact in sub-20 nm nanocarriers, showing that small molecule compatibility and release behavior are influenced by these factors.

This study investigates WSSV infection in wild crustaceans in the Bohai Sea, finding high prevalence rates and confirming infection through electron microscopy.

This study identifies EpCAMlo colon cancer cells with phenotypic plasticity, linking Wnt/β-catenin signaling and EMT activation to metastasis and poor prognosis.

This paper demonstrates that enzyme nanoclusters can depolymerize polyesters via chain-end mediated processive degradation, enabling scalable bioactive plastics for efficient sorting.

This study shows indomethacin inhibits SARS-CoV-2 pseudovirus in vitro and accelerates recovery in CCV-infected dogs compared to ribavirin.

The paper shows that external mechanical cues drive hook formation in plant hypocotyls, with non-canonical auxin pathways and cellulose microfibrils playing key roles.

The paper uses CRISPR-based bioengineering to study TfR trafficking and identifies Rab7 as an intermediate compartment in the Golgi-to-PM transport of neosynthetic TfR.

This study identifies RpvA, a LysR-type regulator in S. aureus, which controls persister formation and virulence by modulating metabolism and virulence gene expression.

This paper develops a method to selectively deliver volatile anesthetics to the spinal cord in rabbits and shows significant differences in their partial pressures between jugular and femoral veins.

This paper develops a mathematical model to quantify nanoparticle permeability in tumors using diffusive flux analysis, showing 3-helix-micelles have higher permeability than other nanoparticles in glioblastoma and colon cancer models.

The paper introduces an open-source software tool for automated tracking of biopolymer networks in 2D and 3D using stretching open active contours, demonstrating its application in live cell studies.