T. Zhang

This paper addresses cross-subject sleep staging by applying contrastive learning based on inter-subject correlation, achieving state-of-the-art performance.

This study identifies CtBP2 as a mediator of Bcl-xL nuclear translocation, which promotes metastasis by enhancing H3K4me3 and TGFβ transcription.

The paper reports a high-resolution crystal structure of a mercury-crosslinked ZIP transporter, revealing dynamic motions and a metal relay mechanism for zinc transport.

The paper investigates metal-driven anaerobic methane oxidation in cold seep sediments, finding that Fe-AOM and Mn-AOM contribute ~3% to methane removal.

This study identifies Plexin-B2 as a driver of homotypic and heterotypic CTC clusters in breast cancer metastasis, with high expression linked to poor prognosis and therapeutic potential.

This study shows that inhibiting subchondral osteoclastogenesis maintains hypoxia in subchondral bone, slowing osteoarthritis progression by stabilizing HIF-1 and reducing cartilage degeneration.

This paper characterizes mitotic phenotypes caused by a MYC synthetic lethal compound, dimethylfasudil, showing cell cycle arrest, mitotic catastrophe, and segregation anomalies.

This study identifies RAY1216, a slow-tight SARS-CoV-2 Mpro inhibitor with improved pharmacokinetics and antiviral activity compared to PF-07321332, currently in phase III clinical trials.

This study maps bile metabolites in mice, showing how infections alter bile composition and affect intestinal homeostasis and defense.

This paper identifies LXY18, a 4-phenoxy-quinoline compound that blocks AURKB relocalization, showing potent antimitotic activity and oral bioavailability.

This study shows that steamed broccoli sprouts reduce DSS-induced colitis in mice by preserving gut microbial diversity and biogeography.

This study shows that a broccoli sprout diet reduces symptoms of Crohn's-like disease in IL-10-KO mice, with stronger effects in younger mice.

This study develops a bivalent vaccine using lineage-mosaic and mutation-patched spike proteins that elicit broad-spectrum antibodies and protect against multiple SARS-CoV-2 variants in hamsters.

The paper investigates the inflorescence architecture of woodland strawberry, showing it is a thyrse regulated by FvTFL1 and FvFT1 antagonism, with a computational model explaining phenotypic diversity through heterochrony.

This study identifies Bifidobacterium pseudolongum as inducing an early anti-inflammatory response that influences cardiac transplant outcomes.

This study develops a high-affinity, specific TCR targeting NY-ESO-1 through engineering and screening, showing efficacy in tumor models and approval for clinical trials.

The paper uses chemical imaging to show that TCA cycle metabolites have distinct roles in root growth and development across species.

This study evaluates an intranasal influenza-based vaccine against SARS-CoV-2 variants, showing it reduces inflammatory response and tissue damage through local immunity.

The paper determines the crystal structure of monkeypox H1 phosphatase, revealing its dimeric form and active site, which informs antiviral drug development.

The paper shows HY5 regulates GLK transcription factors to control chloroplast development and hypocotyl elongation during light-induced seedling development in Arabidopsis.

This paper describes a second-generation recombinant MVA vaccine that enhances antitumor immunity by reprogramming myeloid and T cells through innate-adaptive IFN cross-talk.

This study identifies SAID1/2 as negative regulators of miRNA biogenesis in Arabidopsis by inhibiting the microprocessor complex through phase condensation and SE degradation.

The paper shows polysaccharides trigger deep-sea Lentisphaerae to release chronic bacteriophages that reprogram host polysaccharide metabolism through auxiliary metabolic genes.

The paper introduces a deep redox proteome profiling workflow and applies it to skeletal muscle from mdx mice, revealing increased thiol oxidation and pathway-specific effects.

This study uses native mass spectrometry and structural analysis to show how copper and lipids regulate the ABC transporter MsbA, revealing a conserved KLA binding site that modulates ATPase activity.

This study determines the structure of hPRPS2 polymers using cryo-EM, revealing how ADP binding affects polymerization and catalytic activity.

This study develops an injectable hydrogel with homogenous mesenchymal stem cells to treat severe spinal cord injury in rats, showing improved functional recovery compared to intrathecal delivery.

This study investigates microbiome and short-chain fatty acids (SCFAs) profiles in rumen simulation technique (RUSITEC) systems inoculated with goat and cow rumen contents, identifying copresent microbial genomes associated with substrate degradation.

This study shows benzidine promotes bladder cancer cell proliferation via the ERK5 pathway by increasing cyclin D1 and PCNA while decreasing p21.

This study identifies a bacterial immune system that directly senses a viral capsid protein through a toxin-antitoxin system, revealing a PAMP-like mechanism for innate immunity in bacteria.