W. Zhang

This study investigates T. pyogenes-induced damage to bronchiolar epithelium in vitro and in vivo, identifying inflammatory pathways and potential therapeutic targets.

This study identifies distinct roles of MSH2 and MLH1 in basal-like breast cancer, showing MSH2 promotes metastasis while MLH1 enhances it, and reveals MSH2's role in immune modulation through IFNAR1 regulation.

This study determines the structures of RNA primer/template complexes with adenosine and guanosine ligands, revealing structural reasons for slow RNA primer extension with adenosine substrates.

This study develops bottle-brush polymers optimized for tumour targeting, showing improved delivery efficacy and reduced toxicity in various tumour models.

This study shows FoxP3 forms multimers to bridge DNA through TnG repeats, revealing a new DNA recognition mechanism involving microsatellites.

This paper identifies zotiraciclib as a therapeutic agent targeting IDH-mutant gliomas by disrupting mitochondrial function and inducing oxidative stress, leading to a clinical trial.

This paper develops a DNA-inspired conductive coating for neural microelectrodes, showing improved electrochemical performance and bio-integration compared to conventional materials.

The paper introduces ELAP-seq, a method to detect pseudouridine modifications in RNA with high sensitivity and resolution, identifying over 10,000 sites in human transcripts.

This study compares storage and processing methods for fecal and oral samples to assess their impact on microbiome diversity and composition using 16S rRNA gene sequencing.

The paper develops a mathematical model to study how tumor heterogeneity affects the response to combination therapy in hormone receptor-positive breast cancer, finding that pharmacokinetics and pharmacodynamics of fulvestrant drive treatment outcomes.

This study examines how dietary taurine and carbohydrate levels affect skeletal muscle growth in juvenile turbot, finding that 1.2% taurine with 21% carbohydrates significantly enhances muscle fiber hyperplasia and collagen content.

This paper synthesizes seleno-modified DNA oligonucleotides and shows they resist nuclease digestion while maintaining RNase H activity.

This study uses iPSC-derived neurovascular cells to show impaired BBB function and disrupted tight junctions in CADASIL, highlighting early neurovascular interaction defects.

This study maps ex vivo terminal erythropoiesis from umbilical cord blood mononuclear cells and pluripotent stem cells, identifying differences in regulatory dynamics and CD99 expression affecting erythroid expansion and maturation.

The paper investigates the dynamic behavior of the nuclear pore complex permeability barrier in yeast, showing it functions as a dynamic polymer brush rather than a phase-separated condensate.

This study presents haplotype-resolved genomes of triploid bananas, revealing subgenome asymmetric evolution and resistance mechanisms against banana wilt.

This study improves a DNA polymerase's ability to incorporate modified nucleotides through combinatorial mutagenesis, resulting in a 20-fold efficiency gain.

This paper introduces DABS, a new workflow for natural product discovery that combines isotope labeling with whole cell binding assays, leading to the identification of zillamycin with anti-cancer and anti-microbial activities.

The paper investigates co-transcriptome plasticity in the Arabidopsis-Botrytis pathosystem by analyzing how genetic variation in the pathogen and host influences gene expression.

This study identifies curved adhesions as a new type of integrin-mediated adhesion that forms in soft matrices and is crucial for 3D cell migration.

This study identifies how HBV alters PP2A complexes to drive liver cancer signaling, revealing potential therapeutic targets.

This study identifies RAY1216, a slow-tight SARS-CoV-2 Mpro inhibitor with improved pharmacokinetics and antiviral activity compared to PF-07321332, currently in phase III clinical trials.

This study investigates microRNA-195-3p's role in hypoxia-induced injury of human umbilical vein endothelial cells, finding it upregulated and protective against hypoxia.

The paper develops a high-throughput platform for screening functional neo-antigens and their specific TCRs using droplet microfluidics and DNA barcoding.

This study characterizes 52 patient-derived glioma cell lines with whole-genome sequencing, RNA-seq, and drug response screening, identifying three subtypes and their drug sensitivities and tumorigenic potential.

The paper maps cell landscape and dynamics in rodent bone repair using single-cell RNA sequencing and identifies functional roles of myeloid and lymphoid cells in osteogenesis and angiogenesis.

This study shows that the viral replication protein Rep provides a selective advantage in the presence of CRISPR-Cas immunity by enhancing viral replication efficiency and outcompeting CRISPR-null variants.

This study shows GLI1 promotes rheumatoid arthritis by regulating DNA methyltransferases, leading to M1 macrophage polarization and osteoclast activation, and suggests GLI1 inhibitors as potential treatments.

This study assesses neutralization of SARS-CoV-2 Omicron subvariants by sera from different vaccination and breakthrough infection cohorts, finding that BQ.1.1 and XBB.1.5 show strong neutralization evasion.