X. Lu

The paper identifies hypoxia response regulatory elements using ATAC-seq data from epithelial cells under hypoxia treatment and characterizes their genomic features and transcription factor enrichment.

This study shows that the coronavirus proofreading exoribonuclease nsp14-ExoN is essential for RNA recombination and generates defective viral genomes.

This study identifies three groups of direct repeats in Anabaena sp. PCC 7120 by analyzing the specificities of two Cas6 endonucleases, showing cross-recognition and functional coordination in CRISPR-Cas systems.

This study compares the secretome of Magnaporthe oryzae wild type and Δalg3 mutants, identifying 51 proteins requiring ALG3 for secretion and showing their roles in virulence and cell wall integrity.

The paper characterizes site-specific N-glycosylation of SARS-CoV-2 spike proteins expressed in human and insect cells, revealing differences in glycan types and their implications for infection and vaccine development.

This study identifies MeSSII's role in cassava starch biosynthesis by forming protein complexes with other enzymes, affecting amylose and amylopectin synthesis.

The paper isolates and characterizes SARS-CoV-2 from the first US COVID-19 patient, showing high replication in Vero cells and depositing the strain for public use.

This study applies r- and K-selection to HeLa cells to show how life history strategies influence tumor functional diversity through gene expression and ecological competition.

Marizomib inhibits primary tumor growth and reduces lung and brain metastases in pre-clinical triple-negative breast cancer models.

The paper identifies deamidation at Asn-358 in moxetumomab pasudotox causing conformational changes and reduced immunotoxin activity.

This study uses single-cell profiling to identify immunosuppressive cells in CDK4/6 inhibitor-resistant HER2+ breast cancer and shows that combinatorial immunotherapy can overcome resistance.

The paper identifies the ERF109-MYB51-MYC3 ternary complex as a regulator of jasmonate-induced indolic glucosinolate biosynthesis.

This study identifies GUARDIN as a key regulator of cellular senescence through a LRP130-PGC1α-FOXO4-p21 signaling axis and shows its role in enhancing rapamycin's anti-senolytic effects.

This study evaluates how golden apple snail residues affect soil properties and bacterial communities, finding that they increase soil nutrients and alter bacterial diversity and composition.

This study conducts a histone acetylome-wide association study (HAWAS) of tuberculosis, identifying differentially acetylated loci and their association with immune phenotypes.

This study shows that reversion of a proofreading-deficient coronavirus (ExoN-AA) is hindered by fitness barriers, as compensatory mutations outside the ExoN motif I are more advantageous than partial reversion.

This study analyzes TCR repertoires in RA patients and identifies clonal expansion and shared repertoires between EMT and Th17 cells, correlating TCR diversity with disease activity.

This study shows that climate change has caused a northward shift in the range of wheat pests, leading to increased crop damage despite pesticide use.

This study investigates whether microbial activity in tropical forests is limited by phosphorus availability, finding that P addition increases soil respiration but suppresses litter decomposition due to organic carbon desorption.

This paper analyzes college students' risk perception of pandemic influenza in Beijing using mental model interviews and the Delphi method to identify key risk factors and improve risk communication strategies.

This paper identifies MraW as a DNA methylase in E. coli O157:H7, showing its role in motility, colonization, and virulence through genome-wide methylation and regulation of flagellar genes.

This paper produces transgenic cassava with high amylose starch by silencing BE1 or BE2 genes, showing differences in starch properties between the two gene silencing lines.

This study identifies and analyzes DNA methyltransferase genes in cotton, showing their functional diversity and stress-specific expression patterns.

This study identifies molecular mechanisms of shade responses in maize by analyzing transcriptome changes and functionally testing a key transcription factor.

This study shows sapropterin reduces congenital heart defects in mouse offspring of diabetic mothers by improving eNOS coupling and cell proliferation.

This paper introduces a tumor-specific causal inference framework to identify causative somatic genome alterations and their impact on molecular phenotypes in individual tumors.

This study shows that S-nitrosylation of STIM1 by nNOS inhibits SOCE in cardiomyocytes by stabilizing the luminal domain and preventing oligomerization.

The paper studies mutational meltdown in HeLa cancer cell populations, finding high rates of deleterious copy number variations and significant fitness reduction per mutation.

The paper identifies 5hmC signatures in cfDNA as accurate biomarkers for detecting colorectal and gastric cancers, outperforming conventional markers and matching tissue biopsy results.

This study shows that MHV nsp14 exoribonuclease activity is necessary for resisting innate immunity by affecting viral RNA and modifications.