X. Sun

This study shows that SRP-induced compaction of SR and GTPase movements are essential for efficient cotranslational protein translocation at the ER, with implications for disease.

The paper presents the cryo-EM structure of human ACAT1 and reveals its catalytic mechanism and substrate preference for unsaturated acyl chains.

This study develops SSR markers linked to seed storability traits in maize by mapping QTL in two populations and identifies four markers with high selection efficiency.

This study uses mass spectrometry to show that formaldehyde cross-linking in proteins involves two carbon atoms, not one, and identifies new structural insights from cross-links in human cells.

The paper creates a comprehensive single-cell transcriptome atlas of mouse skin during hair growth and rest, identifying key cell populations and their molecular and spatial organization.

This paper develops a cardiac fibrosis-on-a-chip model that recapitulates fibrosis hallmarks and enables drug screening for anti-fibrotic therapies.

The paper identifies dysbiosis in RA tonsillar microbiota and shows that Streptococcus salivarius and its antibacterial peptides modulate autoimmunity by suppressing T cells and autoantibodies.

This study identifies BRCA1 and other DNA repair factors that suppress LINE-1 retrotransposition in human cells by affecting retrotransposition frequency and ORF2 protein translation.

This study identifies GUARDIN as a key regulator of cellular senescence through a LRP130-PGC1α-FOXO4-p21 signaling axis and shows its role in enhancing rapamycin's anti-senolytic effects.

The paper identifies epigenetic drivers of esophageal squamous cell carcinoma through multi-omics analysis, revealing hypomethylation patterns and non-canonical WNT signaling activation.

This study uses single-cell RNA-seq to analyze human infant retina, identifying cell types, communication networks, and developmental changes, providing a resource for retinal research and regenerative medicine.

This study uses single-cell RNA sequencing to analyze the cellular diversity and molecular markers in the retina of a trisomy 21 fetus, revealing communication networks and novel markers.

This study shows that the I232T SNP in FcγRIIB causes structural changes that reduce ligand binding, contributing to SLE pathogenesis.

This study shows that deoxycholic acid (DCA) reduces Campylobacter jejuni colonization in chickens by altering gut microbiota composition.

This study investigates the dynamic metabolic changes in Ulva prolifera during fragmentation-induced proliferation, identifying key metabolites involved in reproduction and stress response.

The paper identifies a coevolved EDS1-SAG101-NRG1 module essential for TIR-domain immune receptor-mediated cell death signaling in plants.

The paper shows mechanical stress, specifically shear stress, disrupts the CusCBA efflux complex in E. coli, increasing metal toxicity susceptibility.

This paper develops a method to directly synthesize EM-visible gold nanoparticles on genetically encoded tags for single-molecule visualization in cells, achieving high labeling efficiency in both prokaryotic and eukaryotic cells.

This study shows that deoxycholic acid prevents Clostridium perfringens-induced necrotic enteritis in chickens by reducing inflammation through COX signaling inhibition.

This study investigates how the probiotic E. coli Nissle adapts to the mammalian gut under various selective pressures and demonstrates its potential as an engineered therapeutic.

This study shows that VPAC1 and TRPV4 channel interaction promotes calcium-dependent gastric cancer progression through a positive feedback loop involving VIP secretion.

This study shows that high IQGAP3 expression in breast cancer is linked to poor prognosis and resistance to radiation therapy.

The paper simulates G protein activation to identify a new intermediate that drives GDP unbinding, revealing tilting of a helix as the rate-limiting step.

This study identifies L1 protein nuclear entry mechanisms and shows a cell cycle bias for L1 retrotransposition peaking in S phase.

The paper uses in silico SELEX to study mutational robustness of an L-Arm binding aptamer, finding two functional genotype neighborhoods with similar binding affinity to the wild-type.