Y. Chen

This study identifies a distinct metabolic and immune phenotype in women with right-sided colon cancer through gene expression analysis of public datasets.

This study identifies a Clostridia-rich microbiota as a contributor to excessive bile acid excretion in IBS-D patients through metagenomic and metabolomic analyses.

This paper investigates the metabolic response of Pseudomonas taiwanensis to NADH dehydrogenase deficiencies, finding high metabolic flexibility that enables phenotypic stability but complicates metabolic engineering.

This paper evaluates the combination of artesunate and tetramethylpyrazine for treating experimental cerebral malaria, finding improved survival and neurological protection through proteomic analysis.

This paper introduces a microfluidic chip that improves single-cell encapsulation efficiency by fourfold, achieving a 3% co-capturing rate with low doublet rates in sequencing data.

This paper identifies six TSWV-interacting proteins in thrips vectors that bind to the viral attachment protein GN, with two proteins validated as direct interactors, providing new targets for disrupting virus-vector interactions.

The paper investigates the role of endogenous polyamines and associated genes in paraquat resistance in goosegrass, finding that spermidine levels and specific genes correlate with resistance.

This study uses single-cell RNA sequencing to analyze the cellular diversity and molecular markers in the retina of a trisomy 21 fetus, revealing communication networks and novel markers.

This study investigates the localization and role of CK2 in Magnaporthe oryzae during growth and infection, finding it localizes to nuclei, nucleoli, septal pores, and appressoria with regulatory functions.

This study shows that inhibiting TG2 increases radiosensitivity in NSCLC by disrupting TOPOIIα-mediated DNA repair.

This study identifies SKI-73 as a CARM1 chemical probe that reduces breast cancer cell invasion by altering epigenetic plasticity, distinct from CARM1 knockout effects.

The paper investigates pre-existing adaptive immune responses to CRISPR Cas proteins and AAVs in non-human primates and finds such immunity is普遍存在 regardless of Cas proteins or AAVs.

This study develops a sphere-forming assay to isolate a malignant subpopulation from a CRC cell line and identifies DPEP1 as a prognostic biomarker.

The paper identifies arthritogenic CD4 T cells in murine and human autoimmune arthritis using Nur77 as a marker of TCR signaling.

This study systematically measures mutant phenotypes for genes in Bacteroides thetaiotaomicron to uncover gene functions and improve understanding of gut microbiota physiology.

The paper identifies differentially expressed proteins in tumor-associated vascular endothelial cells of colorectal cancer and links some to angiogenesis and metastasis.

This study examines T cell function changes in a rat cardiac arrest model after ROSC, finding reduced T cells, increased co-inhibitory molecules, and a shift from Th1 to Th2 responses.

The paper examines age and sex effects on gut microbial diversity across four adult cohorts, finding age-related diversity increases in young adults and sex differences in some groups.

The paper introduces a multi-immersion open-top light-sheet microscope for high-throughput imaging of cleared tissues using various clearing protocols.

The paper analyzes 12 Shigella sonnei strains to compare virulence and antibiotic resistance, finding that resistant strains have more virulence factors and distinct genetic clusters.

This study identifies airway contributions to alveolar maintenance and lung adenocarcinoma development through mouse models and transcriptomic analysis.

This study identifies Eg5 as a microtubule polymerase that promotes microtubule growth by inducing a curved-to-straight transition in tubulin.

This study enhances methyl ketone production in Pseudomonas putida using plant-derived amino acids from hydrolysates, achieving a 9-fold increase in titer.

The paper shows that genes encoding the same protein complex replicate synchronously in fast-proliferating cells like cancer cells to maintain stoichiometry, but not in slow-proliferating cells.

The paper uses genomic mining to uncover the evolutionary history of porcine endogenous retroviruses (PERVs), revealing their origins and cross-species transmission events.

The paper discovers a new endogenous foamy virus in tuatara, showing co-divergence with its host and filling a gap in retrovirus evolution.

This study shows that loss of Apc function in intestinal epithelial cells reduces IL-22 receptor expression and STAT3 activation, leading to resistance to IL-22 and increased genetic instability.

This paper identifies a stable expression hot spot in Chinese hamster ovary cells using a lentivirus-based random integration method and validates its long-term expression stability.

This study characterizes the rhizosphere fungal community structure of tetraploid cotton and finds it varies with soil type, cotton genotype, and developmental stage.