Y. Chen

The paper identifies RaxX as a sulfated RiPP that binds the rice immune receptor XA21, revealing its role in bacterial immune activation.

This study investigates the structure and function of the estrogen receptor alpha N-terminal domain using multiple techniques, revealing metastable contacts and their role in transactivation.

The paper demonstrates a strong positive biodiversity-productivity relationship in a subtropical forest experiment, showing increased productivity with species richness and complementary effects over time.

This study identifies genome-wide nucleotide sites associated with mammalian virulence in influenza A viruses and develops machine-learning models to predict virulence.

This study shows that vitamin A supplementation after neonatal Streptococcus pneumoniae pneumonia reduces allergic asthma in mice by altering CD4+ T cell subsets.

This study evaluates how well fecal samples represent chicken gut microbiota, finding that feces can identify most taxa but not fully capture microbial community structure.

This study investigates how viral lysis products affect the transcriptome of Prochlorococcus, revealing changes in tRNA abundance, nitrogen metabolism, and photosynthetic efficiency.

The paper shows PARP1 activation in response to DNA damage causes NAD+ depletion, leading to a metabolic shift to oxidative phosphorylation, which supports cell survival.

The paper examines gene regulatory divergence between locally adapted ecotypes of Mimulus guttatus in their native habitats, finding widespread differential expression and cis-trans regulatory variation.

The paper identifies and maps the stripe rust resistance gene YrTZ2 in wild emmer wheat and compares its genomic region with Aegilops tauschii.

This paper develops a simple Liver-on-a-Chip platform using hPSC-derived hepatocyte-like cells, showing improved hepatic function and maturation.

The paper analyzes ascitic microbiota composition in cirrhotic patients and finds two microbial clusters associated with different clinical outcomes, particularly higher short-term mortality in one cluster.

This study shows that anisotropic growth in Arabidopsis hypocotyls results from the combined mechanical effects of cellulose orientation and pectin-based elastic asymmetry.

This study shows hemolysin facilitates cytosolic LPS sensing by liberating bacterial outer membrane vesicles, leading to inflammasome activation and gut inflammation.

This study identifies miR-452-5p as a key regulator of renal cancer metastasis, showing its upregulation and role in promoting invasion through SMAD4/SMAD7/EMT signaling.

The paper uses citizen-science data to analyze human stool microbiomes, revealing new insights into microbial diversity, metabolome composition, and associations with diet and health.

This study identifies mutations in specific genes associated with clofazimine resistance in Mycobacterium abscessus through whole genome sequencing of resistant mutants.

Glaser et al. describe a light-sheet microscopy architecture that enables passive multidirectional illumination with confocal line detection to enable both uniform fluorescence excitation and contrast-enhanced imaging of fluorescently labeled samples.

This study uses molecular dynamics simulations to investigate how phosphorylation of PAGE4 affects its structure and interactions with AP-1 and AR, revealing conformational switching linked to prostate cancer progression.

The paper investigates how DNA replication licensing is delayed in Lgr5+ intestinal stem cells, linking it to their extended G1 phase and proliferative fate decisions.

The paper improves the generation of virtual populations in QSP models by using alternative optimization algorithms and objective functions to reduce the number of required virtual patients while maintaining diversity.

This study investigates the sequential O-glycosylation of an adhesin in Streptococcus gordonii and its interaction with accessory Sec proteins for export.

The paper develops and validates a new red fluorescent calcium indicator, K-GECO1, based on a circularly permutated RFP from a sea anemone, tested across multiple cell types and organisms.

The paper develops a base-resolution m1A profiling method and identifies distinct m1A methylome classes in human nuclear and mitochondrial transcripts, showing functional roles in translation efficiency and mitochondrial mRNA regulation.

This study shows that liraglutide reduces obesity-induced kidney injury by restoring renal lipid and energy metabolism through metabolic and molecular mechanisms.

This study identifies genomic variations in normal lung tissues paired with lung adenocarcinomas, revealing tobacco-induced DNA damage and associations with patient prognosis.

The paper introduces a new method to estimate soil organic carbon stocks by accounting for soil volume changes, revealing an additional carbon sink in global forests.

The paper clusters pediatric and adult sarcoma data using optimal transport theory and identifies a unique pediatric cluster.

This study uses oil emulsion droplets as mechanical sensors to measure cell forces during HL-60 cell migration under confinement, revealing acto-myosin contraction's role in obstacle crossing.