Y. Deng

This study identifies a novel long ERα isoform enriched in female reproductive tissues and shows its critical role in reproductive function in female mice.

This study identifies tryptamine, a gut microbiota-derived metabolite, as a contributor to insulin resistance in type 2 diabetes through TAAR1-ERK signaling.

This study identifies the Toll pathway as a key antiviral defense in honey bees, with PGRP-S2 acting as a pattern recognition receptor that interacts with viral proteins to activate the pathway against IAPV infection.

This study shows miR-138 suppresses HSV-2 lytic infection by targeting viral and host genes, with distinct mechanisms compared to HSV-1.

The paper identifies GATOR1 as a tumor suppressor in MYC-driven lymphomagenesis using in vivo CRISPR screens and shows its sensitivity to mTOR inhibitors.

This study demonstrates systemic gene editing using PNA nanoparticles to correct the F508del CFTR mutation in mice, showing partial CFTR function restoration and tissue-specific correction without off-target effects.

Antibodies from 3-dose vaccinated individuals neutralize Omicron and other variants, with some being ultrapotent and broadly reactive.

This study uses snRNA-seq and Stereo-seq to analyze the immunological microenvironment of cervical squamous cell carcinoma, identifying immune cell clusters and their associations with tumor progression and patient survival.

This study identifies and validates multiple novel targets of HSV-1 ICP0 in neuronal cells using proteomic approaches and functional experiments, revealing potential restrictive activities of SNX9 and OTUD4.

This study examines how sulfite preservatives affect saliva microbiota viability, diversity, and composition, finding significant changes in bacterial abundance and activity.

This study shows that CD147 antibody inhibits SARS-CoV-2 infection and cytokine storm in variants by blocking viral entry and reducing inflammatory responses.

The paper introduces JAMMIT, an algorithm that identifies three immune-related immunophenotypes common to 29 solid tumors using TCGA data.

The paper identifies non-reproducible antibody-antigen interactions in clinical sera and develops a model to explain them, improving serological testing for viral infections like COVID-19.

This study demonstrates that iDPC-STEM provides superior contrast and structural detail in biological samples compared to conventional TEM, especially at low doses and for thick sections.

This study identifies novel apelin-expressing gCap endothelial stem-like cells that drive lung microvascular repair after endothelial cell ablation by apelin signaling.

This paper introduces OU-PIC, an extension of Felsenstein's PIC method under the Ornstein-Uhlenbeck model, showing improved statistical performance in detecting correlated trait evolution.

The paper analyzes single-cell data from CAR T infusion products to identify factors associated with CD19-positive relapse in ALL patients.

This paper identifies Rab5a as a host factor that RSV activates to suppress IRF1-dependent IFN-λ production, thereby reducing antiviral immunity in airway epithelial cells.

The paper identifies a Ca2+-activated sphingomyelin scrambling pathway that mediates ESCRT-independent lysosomal repair by converting sphingomyelin into repair intermediates.

This paper introduces a method to recognize small biomolecules through dose-effect interdependence encoded in chromatographic microassay arrays, applied to natural products for high-throughput screening.

The paper introduces a computational model linking LOXL2 secretion to ECM stiffness and ZEB1 levels, showing a positive feedback loop that locks cells in a mesenchymal state during EMT.

This study designs and characterizes potent bisubstrate inhibitors for NatD, showing high selectivity and revealing the enzyme's ordered Bi-Bi mechanism through crystal structures.

This study shows that adiponectin improves healthspan and lifespan by enhancing insulin sensitivity and reducing age-related metabolic and inflammatory disorders in mice.

This study analyzes H7N9 virus genome mutations in human clinical samples to identify potential adaptations during infection.

The paper derives an analytic expression for waiting distances in ancestral recombination graphs and identifies biases in existing tree inference methods.

This study develops and tests a recombinant RBD-Fc vaccine against SARS-CoV-2, showing protection in non-human primates and mice.

A cocktail of neutralizing antibodies targeting SARS-CoV-2 spike protein's NTD and RBD, when used as immunogens in rabbits, elicited strong protective immune responses.

The paper designs and synthesizes a potent dual-selective bisubstrate inhibitor for PRMT4/5, demonstrating high potency and selectivity with IC50 values of 2.8 nM and <1.5 nM.

This study shows that heat processing increases hydrophobicity of proteins, enhancing their uptake by macrophages and dendritic cells, but not triggering cytokine responses.