Y. Li

The paper constructs a genome-scale fungal phylogeny using 1,644 species and multiple data matrices, finding robust relationships and identifying taxonomic discrepancies.

The paper identifies lanthipeptide synthetases as key enzymes in the biosynthesis of 2-aminovinyl-cysteine motifs in thioamitides, revealing their role in dehydration and macrocyclization.

This paper reports an AviCys formation pathway in thioviridamide non-lanthipeptides that does not require lanthionine synthetase activity.

The paper identifies microbial markers for early colorectal cancer detection across populations using meta-analysis and classifier models, achieving high diagnostic accuracy.

This study shows dietary propionate causes intestinal oxidative stress in zebrafish by inhibiting SIRT3-mediated SOD2 depropionylation, leading to gut microbiota changes.

This study shows that loss-of-function mutations in Fbxo10 do not increase BCL2 or B lymphocyte numbers in mice, suggesting redundant regulation of BCL2 by other ubiquitin ligases.

This paper demonstrates that mass photometry can detect and quantify nucleic acids with high accuracy and speed, using sub-picomole samples.

This study examines the effects of different dietary protein levels on ewe growth, serum biochemistry, and lamb development during late pregnancy, finding no significant impact on growth performance but significant effects on metabolic indicators and lamb body measurements.

This study shows an inactivated SARS-CoV-2 vaccine induces neutralizing antibodies and CTL responses in rhesus macaques, effectively preventing viral replication and lung inflammation.

This study examines how maize plants respond to drought, flooding, and rewatering, finding that photosynthetic traits recover after rewatering, with resilience depending on drought severity and plant growth stage.

This paper introduces a label-free imaging cytometry method using deep learning to predict subcellular features from reflectance microscopy, achieving higher accuracy and throughput for single-cell analysis.

This study examines how wildfire and its legacy through charcoals affect soil microbial communities in boreal forests over a 29-year chronosequence.

This study examines the relationship between neuroendocrine and immune gene expression in SCLC, finding that variant SCLC tumors regain immune gene expression and exhibit higher tumor-immune interactions.

This study shows a combination of DYRK1A inhibitor and GLP1R agonist increases human beta cell mass in vivo by 400-700% in mice, using iDISCO+ 3D imaging for quantification.

This study uses computational modeling to show that reducing IK1 and increasing If in ventricular myocytes can generate stable pacemaking activity, providing a theoretical basis for engineered biological pacemakers.

This study shows that OmcS is not essential for long-range electron transport in G. sulfurreducens strain KN400, as its deletion does not impair Fe(III) oxide reduction or direct interspecies electron transfer.

This study identifies FXR1 as a driver of cMYC translation through mRNA circularization and eIF4F recruitment in ovarian cancer, linking FXR1 amplification to poor prognosis.

This paper develops a lentiviral vector for β-thalassemia treatment that restores β-globin expression in Chinese patients with minimal tumorigenesis risk.

This study identifies a mechanism by which pseudogene 5 induces DNA demethylation and reactivates the oncogene SALL4 in hepatocellular carcinoma, linking HBV infection to HCC progression.

This study uses long-read sequencing and proximity ligation mapping to analyze genetic diversity in two T. cruzi strains, revealing mechanisms of gene amplification, dispersion, and recombination that contribute to immune evasion and genome evolution.

This paper describes a catalase-based therapeutic for COVID-19 that reduces oxidative stress and cytokine production in human and animal models without toxicity.

The paper tests whether beta-diversity contributes to the latitudinal gradient in species richness by analyzing tree species data across East Asia.

The paper performs pan-genome analysis of peach and its wild relatives to identify genetic variations related to disease resistance and high-altitude adaptation.

This study shows increased epidermal green autofluorescence in skin and nails of lung cancer patients and mice, suggesting it as a potential non-invasive diagnostic biomarker.

This paper identifies and characterizes the NIC1-locus in tobacco, showing it regulates nicotine biosynthesis through ERF genes that function downstream of NtMYC2 in the JA signaling pathway.

This study evaluates dietary protein sources using a combined experimental and computational approach, showing that protein source type does not drive clustering of bioactive peptide delivery potential.

This paper evaluates the accuracy of FFP-based phylogenies and finds they perform poorly compared to standard methods like concatenation and coalescence.

This study reports cryo-EM structures of NLRP1-CT and CARD8-CT inflammasome assemblies, revealing unique filament formation mechanisms and ASC recruitment specificity.

The paper presents a near-complete yeast proteome dataset using optimized sample preparation and high-resolution mass spectrometry, identifying 5610 proteins with 94.1% coverage of yeast ORFs.

This study reveals how target RNA binding regulates Cmr-β complex activities through conformational changes, enabling immune responses against genetic invaders.