Y. Li

This study identifies IAN9 and IAP1 as negative regulators of basal immunity in Arabidopsis, with potential applications for improving disease resistance in crops.

The paper identifies the N-cadherin interactome in primary cardiomyocytes using proximity proteomics, revealing over 350 proteins, many unique to CDH2.

This study shows DNA methylation in corals reduces transcriptional noise and enables phenotypic acclimatization to ocean acidification by altering cell and polyp sizes.

This study identifies CHOP and IRE1α-XBP1/JNK signaling as mediators of NDV-induced apoptosis and their role in promoting virus proliferation in tumor cells.

This study compares the nuclear export and cargo dissociation mechanisms of RanBP1 in fungi and animals, revealing distinct interactions and complex stoichiometry.

This paper introduces a new non-radioactive assay for HS2ST activity using a synthetic fluorescent substrate and identifies protein kinase inhibitors that inhibit HS2ST-catalyzed sulphation.

The paper develops a non-radioactive assay to quantify tyrosine sulphation by TPST1 and TPST2 and identifies RAF kinase inhibitors as potential TPST inhibitors.

This study examines the longevity of dental restorations in geriatric and adult special needs patients over 15 years, finding median survival of 6.25 years and factors associated with restoration failure.

The paper develops a theoretical model showing how cell migration transitions from actin-driven to water-driven mechanisms based on environmental constraints.

This study investigates how cell volume in non-excitable tissue cells is regulated by membrane potential and ion concentrations, showing volume changes under different conditions.

The paper investigates the interaction between the TIP60 chromo barrel domain and histone peptides, finding no binding observed through fluorescence polarization or isothermal titration calorimetry and presenting a crystal structure of the domain.

The paper reports the crystal structure of RBBP1's chromo barrel domain and shows it does not bind DNA, contradicting previous reports of DNA-enhanced histone binding.

The paper investigates DNA methylation's role in maintaining transcriptional homeostasis during algal endosymbiosis in Aiptasia, finding it reduces transcriptional noise and regulates symbiosis-related processes.

The paper demonstrates a label-free method to detect ligand binding to cell surface proteins by monitoring membrane capacitance changes in real time using the serotonin transporter as a model.

This study investigates how 1,25-dihydroxyvitamin D3 and fluid shear stress together affect osteoblast function, showing their combined impact on nitric oxide release, proliferation, PGE2 release, and differentiation.

The paper identifies 41 frequently mutated regulatory elements in cancer genomes, enriched in non-coding mutations and linked to gene expression control through chromatin interactions.

This study identifies dynamic protein aggregation as a regulator of bacterial dormancy depth, influencing antibiotic tolerance and resuscitation.

This study shows MapZ forms a stable ring in Streptococcus mutans that guides FtsZ treadmilling, controlling cell division.

This study identifies natural variation in OsLG3 that enhances drought stress tolerance in rice by improving ROS scavenging, offering a genetic resource for breeding drought-tolerant rice.

This paper introduces a method to simultaneously measure cell traction forces and growth using light-based imaging, showing that mesenchymal stem cells exert different forces during osteogenesis and adipogenesis.

The paper studies mutational meltdown in HeLa cancer cell populations, finding high rates of deleterious copy number variations and significant fitness reduction per mutation.

This study shows that MHV nsp14 exoribonuclease activity is necessary for resisting innate immunity by affecting viral RNA and modifications.

This study shows replication defective viral genomes (DVGs) protect certain cells from death and promote viral persistence by activating a TNF-mediated survival pathway during infection.

The paper introduces a fast and precise 3D localization method for arbitrary PSFs, achieving high resolution and speed on standard microscopes.

The paper quantifies protein-membrane interactions using single-molecule force spectroscopy, showing C2 domains resist forces of 2-7 pN and have binding energies of 4-14 kBT.

This study examines how maize plants respond to drought and rewatering, finding that leaf functional traits do not fully recover after drought and recovery strength depends on drought duration.

This study identifies CD55 as a signaling hub that regulates self-renewal and cisplatin resistance in endometrioid tumors through distinct signaling pathways.

This study uses IVIM parameters to differentiate early-stage hepatitis-B fibrotic livers from healthy livers with high accuracy.

The paper shows that experimental duration and predator satiation significantly affect functional response parameters like attack rate and handling time, impacting population dynamics models.