Y. Li

This study shows that vinculin is essential for linking contractile actomyosin to cardiomyocyte adherens junctions, promoting junction maturation and mechanical stability.

This paper introduces a super-resolution microscope that images whole mammalian cells at ~20 nm 3D resolution, revealing complex cellular structures previously only visible via electron microscopy.

This paper proposes a tree-like data structure for the 3D genome to explain its physical properties and folding principles.

The paper samples adaptive mutations in yeast to identify tradeoffs and Pareto fronts between growth cycle traits, finding that no single mutation can circumvent these constraints.

This study shows that MALT1 regulates endo-lysosome homeostasis and glioma cell survival, with MALT1 inhibition leading to lysosomal-mediated cell death.

The paper identifies a TP53 noncoding variant that alters cancer susceptibility by affecting miRNA targeting sites, leading to tissue-specific p53 regulation and differential cancer risk.

The paper uses genome-edited cell lines with labeled nuclear pore complexes to serve as reference standards for quantitative superresolution microscopy.

The intestinal microbiota induces daily metabolic rhythms and controls lipid uptake through the enzyme histone deacetylase 3.

This study investigates the dynamic metabolic changes in Ulva prolifera during fragmentation-induced proliferation, identifying key metabolites involved in reproduction and stress response.

This study examines C4d deposition in renal tissues of primary Sjögren's syndrome patients, finding higher serum creatinine levels in those with tubulointerstitial C4d positivity.

This study determines high-resolution cryo-EM structures of E. coli hemolysin ClyA oligomers, revealing new oligomeric states and mechanistic insights into pore assembly.

This paper develops a method to correct depth-induced aberrations in 3D single-molecule localization microscopy by using an imperfect PSF model and post-processing error correction.

The paper identifies MISTERMINATE as a mechanism linking mitochondrial dysfunction to proteostasis failure through translational termination impairment and C-terminal extension of mitochondrial proteins.

The paper analyzes 12 Shigella sonnei strains to compare virulence and antibiotic resistance, finding that resistant strains have more virulence factors and distinct genetic clusters.

The paper visualizes replication foci during S-phase and reveals a CTCF-dependent hierarchical radial propagation pattern that reverses directionality over time.

This study reports crystal structures of the HMCES SRAP domain bound to DNA-damage substrates, revealing how HMCES recognizes and binds different DNA structures for crosslinking.

The paper uses p19 to capture RNase III-cleaved dsRNA in E. coli, revealing widespread antisense transcription and its potential role in stress responses.

This study examines how Kuntai capsules affect LIF, IGF-1, and EGF expression in mice endometrium during the implantation window, finding they partially improve endometrial receptivity.

This study identifies α-tubulin in Laodelphax striatellus as a facilitator of rice stripe virus (RSV) passage through midgut and salivary glands, enhancing horizontal transmission.

This study investigates exocyst dynamics in mammalian cells, revealing tetrameric subcomplexes that dynamically associate with vesicles and plasma membrane.

The paper develops a biosensor to study 2-5A kinetics and shows that interferons β and λ evade RNase L-mediated translation arrest during the innate immune response.

This study shows that increasing intracellular nitric oxide in SHR reduces VSMC hyperproliferation by inhibiting AT1 receptor and growth factor receptor signaling pathways.

This paper develops a microplate assay using collagen hybridizing peptides to quantify denatured collagen, showing it is reliable and efficient compared to existing methods.

This paper engineers NK cells with a recombinant Fc receptor to enhance ADCC and tumor targeting by avoiding ADAM17-mediated downregulation.

This paper identifies and characterizes a novel paraoxonase-like enzyme in Trichoderma atroviride strain T23 that degrades DDVP and related organophosphate-oxons, showing high activity and specific kinetic parameters.

The paper identifies a multidrug-resistant P. aeruginosa strain with hyperactive quorum sensing that enhances virulence and resistance.

The paper describes a new standing rest behavior in Tibetan antelopes called 'Puppet behavior,' observed more frequently in males and linked to thermoregulation and anti-predation.

This study identifies Cyclin B3's specific role in facilitating metaphase-to-anaphase transition in mouse oocyte meiosis I, while showing it is not required for oocyte maturation or sister chromosome segregation.

This study evaluates how cytological preparation affects nanoscale chromatin changes using PWS microscopy in cancer cell models, showing that modifications can preserve clinically relevant nanoscopic differences.

This study uses single-molecule imaging to show dynamic exchange of DNA polymerases and clamp loader during replication and fork arrest in Bacillus subtilis.