Y. Ren

The paper compares the tumor-repressing effects of TCF11 and Nrf1, showing TCF11 is more potent, while both have similar regulatory profiles distinct from Nrf2.

The paper presents a cryo-EM structure of the yeast THO*Sub2 complex and shows its interaction with the SR-like protein Gbp2, suggesting a role in mRNP maturation.

This study uses proteomics to identify complement cascade pathway changes in gastric signet ring cell carcinoma tissues compared to adjacent regions and adenocarcinomas.

This study identifies PCSK9 as a target to enhance CD8+ T cell antitumor activity by modulating LDLR and TCR signaling in the tumor microenvironment.

This study shows BCL-XL antagonists reduce HIV in a cell model of latency but not in ex vivo reservoirs, suggesting resistance in true reservoir cells.

This study shows that exogenous calcium is toxic to fungal cells lacking calcineurin, a key calcium regulator, and that this toxicity is linked to cytosolic calcium overload and vacuolar storage deficits.

This paper evaluates a randomized basket trial design that controls false positive rate by indication, showing improved efficiency compared to parallel studies.

This study identifies gut microbiota changes and their associations with cerebral cortex and cerebrovascular abnormalities in human mild traumatic brain injury.

This paper identifies and profiles bisecting N-acetylglucosamine modifications in human amniotic membrane through glycomic and glycoproteomic analyses, revealing 41 glycoproteins with this modification.

This study identifies lipid differences in plasma, microvesicles, and exosomes between preterm and full-term pregnancies, finding microvesicle lipids better predict preterm birth risk.

This study profiles the 2-hydroxyisobutyrylome in common wheat, identifying Khib modification sites and their roles in metabolic pathways and enzyme regulation.

The paper presents a large multi-omic cohort of 2,183 adults to identify correlations between gut microbiome features and various health-related factors, validated in an additional cohort.

This study analyzes the vagino-cervical microbiome of 516 women using metagenomic shotgun sequencing to explore how pregnancy, delivery, and contraception influence microbiome composition.

This study shows Nrf1 represses tumor growth by inhibiting Wnt/β-catenin signaling and other pathways through ubiquitination of β-catenin and regulation of key genes.

The paper shows that ASCL1-regulated DARPP-32 and t-DARPP promote SCLC growth and survival through Akt/Erk signaling and anti-apoptotic pathways, with t-DARPP overexpression linked to Notch signaling activation in SCLC patients.

This study identifies Abcg2-expressing side population cells in the heart that contribute to cardiomyocyte renewal via fusion rather than direct differentiation following injury.

This study identifies glucose starvation and SGLT2 inhibition as synthetic lethal strategies for EGFR-WT/LKB1-mutant NSCLC, showing efficacy in xenograft models.

This study evaluates bio-bitumen made from biomass pyrolysis oil as a substitute for petro-bitumen in coating sheets, showing improved adhesion, temperature stability, mechanical strength, and flexibility.

The paper establishes a baseline human gut microbiota profile and provides a reference database and reporting tool for clinical and research applications.

This study uses molecular dynamics simulations to model pHLIP's state II and a fast-folding variant, revealing binding mechanisms and helical folding during membrane interaction.

This study examines the correlation between neutralization breadth and infected-cell binding of broadly neutralizing antibodies against HIV reactivated from latent reservoirs.